{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115581"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115581","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Mechanisms of regulation of sloppy-paired genes in the temporal patterning program of optic lobe medulla neuroblasts in drosophila","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","abstract_has_math":false,"creators":["Ray, Alokananda"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Cell and Developmental Biology","degree_department":null,"school":null,"contributors":["Li, Xin","Chen, Jie","Smith-Bolton, Rachel","Raetzman, Lori"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:54Z","subjects":["Temporal patterning","optic lobe development","neuroblasts","Drosophila"],"languages":["en","eng"],"rights":["Copyright 2022 Alokananda Ray"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115581","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Li, Xin","Chen, Jie","Smith-Bolton, Rachel","Raetzman, Lori"]},{"key":"dc:creator","label":"Author","values":["Ray, Alokananda"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-21"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Cell and Developmental Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Temporal patterning","optic lobe development","neuroblasts","Drosophila"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Alokananda Ray"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115581"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","The student, Alokananda Ray, accepted the attached license on 2022-04-19 at 12:16.","The student, Alokananda Ray, submitted this Dissertation for approval on 2022-04-19 at 12:49.","This Dissertation was approved for publication on 2022-04-21 at 11:52.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17801 on 2022-11-11 at 12:06:10","The generation of various neurons, each with specialized functional roles, from a small initial pool of neural stem cells presents a challenge for developing brains in higher animals. Temporal patterning, whereby neural stem cells specify distinct fates in their progeny in a birth-order dependent manner, is a crucial mechanism for achieving neural diversity and is conserved across species from fruit flies to mammals. However, detailed molecular mechanisms underlying temporal patterning are not entirely understood. In the work described in the following chapters, I have characterized the regulatory mechanisms controlling the expression of temporal patterning transcription factors Sloppy-paired 1 (Slp1) and Sloppy-paired 2 (Slp2) in optic lobe medulla neuroblasts in the model organism Drosophila melanogaster. I have demonstrated that at transcription, Slp1 and Slp2 are regulated by at least two cis-regulatory elements that function additively and drive expressions of these two genes in the pattern observed in medulla neuroblasts. I also showed that the Notch signaling pathway and the cell cycle contribute to the regulation of Slp1 and Slp2 protein expressions in this context. Together these results provide greater insight into how disparate cellular processes such as the cell cycle and signaling pathways such as Notch and temporal patterning interact to achieve precise developmental outcomes."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Mechanisms of regulation of sloppy-paired genes in the temporal patterning program of optic lobe medulla neuroblasts in drosophila"]}]}],"canonical_facts":{"dc:contributor":["Li, Xin","Chen, Jie","Smith-Bolton, Rachel","Raetzman, Lori"],"dc:creator":["Ray, Alokananda"],"dc:date":["2022-05","2022-04-21"],"dc:description":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","The student, Alokananda Ray, accepted the attached license on 2022-04-19 at 12:16.","The student, Alokananda Ray, submitted this Dissertation for approval on 2022-04-19 at 12:49.","This Dissertation was approved for publication on 2022-04-21 at 11:52.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17801 on 2022-11-11 at 12:06:10","The generation of various neurons, each with specialized functional roles, from a small initial pool of neural stem cells presents a challenge for developing brains in higher animals. Temporal patterning, whereby neural stem cells specify distinct fates in their progeny in a birth-order dependent manner, is a crucial mechanism for achieving neural diversity and is conserved across species from fruit flies to mammals. However, detailed molecular mechanisms underlying temporal patterning are not entirely understood. In the work described in the following chapters, I have characterized the regulatory mechanisms controlling the expression of temporal patterning transcription factors Sloppy-paired 1 (Slp1) and Sloppy-paired 2 (Slp2) in optic lobe medulla neuroblasts in the model organism Drosophila melanogaster. I have demonstrated that at transcription, Slp1 and Slp2 are regulated by at least two cis-regulatory elements that function additively and drive expressions of these two genes in the pattern observed in medulla neuroblasts. I also showed that the Notch signaling pathway and the cell cycle contribute to the regulation of Slp1 and Slp2 protein expressions in this context. Together these results provide greater insight into how disparate cellular processes such as the cell cycle and signaling pathways such as Notch and temporal patterning interact to achieve precise developmental outcomes."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115581"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Alokananda Ray"],"dc:subject":["Temporal patterning","optic lobe development","neuroblasts","Drosophila"],"dc:title":["Mechanisms of regulation of sloppy-paired genes in the temporal patterning program of optic lobe medulla neuroblasts in drosophila"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Cell and Developmental Biology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:54Z"}