{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/114110"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/114110","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Finasteride lowers cholesterol in humans and delays atherosclerosis progression in Ldlr-/- mice","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","abstract_has_math":false,"creators":["McQueen, James Patrick"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Amengual , Jaume","Erdman , John","Flaws, Jodi"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-04-29T21:58:41Z","date_published":"2022-04-29T21:58:41Z","updated_at":"2026-07-22T22:24:54Z","subjects":["Nutritional science"],"languages":["en","eng"],"rights":["Copyright 2021 James McQueen"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/114110","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Amengual , Jaume","Erdman , John","Flaws, Jodi"]},{"key":"dc:creator","label":"Author","values":["McQueen, James Patrick"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-04-29T21:58:41Z","2024-04-29T21:58:46Z","2021-12","2021-12-09"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Nutritional science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 James McQueen"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/114110"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","The student, James McQueen, accepted the attached license on 2021-12-08 at 13:51.","The student, James McQueen, submitted this Thesis for approval on 2021-12-08 at 14:13.","This Thesis was approved for publication on 2021-12-09 at 15:59.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17414 on 2022-04-29 at 16:10:44","Made available in DSpace on 2022-04-29T21:58:41Z (GMT). No. of bitstreams: 2 MCQUEEN-THESIS-2021.pdf: 5847664 bytes, checksum: 8e8e44319046f06accc1a7340c9411f7 (MD5) LICENSE.txt: 4212 bytes, checksum: b9beba1ecf644bd2169320ca4a659a43 (MD5) Previous issue date: 2021-12-09","Embargo set by: Seth Robbins for item 123475 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","Plasma cholesterol and sex hormones are strong risk factors associated with atherosclerosis, the leading cause of death worldwide. The objective of this study was to determine the role of finasteride, a drug that inhibits the activation of testosterone to dihydrotestosterone, on plasma lipid profile and atherogenesis. For our clinical study, we applied regression models to examine associations between circulating lipid profile and finasteride using the National Health and Nutrition Examination Survey database. After controlling for covariates, we observed a significant reduction in total cholesterol levels in subjects taking finasteride. In our preclinical model, we tested the effect of finasteride in atheroprone low-density lipoprotein receptor-deficient (Ldlr-/-) mice fed increasing doses of finasteride for 12 weeks. Finasteride reduced circulating cholesterol levels and resulted in a reduction in lesion size, necrotic core area, and immune cell content. Global transcriptome analysis of liver showed an up-regulation of bile acid biosynthesis and oxidative phosphorylation, accompanied by a reduction in inflammatory markers. Our results show that finasteride is associated with a reduction in plasma cholesterol in both human and mice and highlight the potential role of this drug in the reduction of atherosclerosis."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Finasteride lowers cholesterol in humans and delays atherosclerosis progression in Ldlr-/- mice"]}]}],"canonical_facts":{"dc:contributor":["Amengual , Jaume","Erdman , John","Flaws, Jodi"],"dc:creator":["McQueen, James Patrick"],"dc:date":["2022-04-29T21:58:41Z","2024-04-29T21:58:46Z","2021-12","2021-12-09"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","The student, James McQueen, accepted the attached license on 2021-12-08 at 13:51.","The student, James McQueen, submitted this Thesis for approval on 2021-12-08 at 14:13.","This Thesis was approved for publication on 2021-12-09 at 15:59.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17414 on 2022-04-29 at 16:10:44","Made available in DSpace on 2022-04-29T21:58:41Z (GMT). No. of bitstreams: 2 MCQUEEN-THESIS-2021.pdf: 5847664 bytes, checksum: 8e8e44319046f06accc1a7340c9411f7 (MD5) LICENSE.txt: 4212 bytes, checksum: b9beba1ecf644bd2169320ca4a659a43 (MD5) Previous issue date: 2021-12-09","Embargo set by: Seth Robbins for item 123475 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","Plasma cholesterol and sex hormones are strong risk factors associated with atherosclerosis, the leading cause of death worldwide. The objective of this study was to determine the role of finasteride, a drug that inhibits the activation of testosterone to dihydrotestosterone, on plasma lipid profile and atherogenesis. For our clinical study, we applied regression models to examine associations between circulating lipid profile and finasteride using the National Health and Nutrition Examination Survey database. After controlling for covariates, we observed a significant reduction in total cholesterol levels in subjects taking finasteride. In our preclinical model, we tested the effect of finasteride in atheroprone low-density lipoprotein receptor-deficient (Ldlr-/-) mice fed increasing doses of finasteride for 12 weeks. Finasteride reduced circulating cholesterol levels and resulted in a reduction in lesion size, necrotic core area, and immune cell content. Global transcriptome analysis of liver showed an up-regulation of bile acid biosynthesis and oxidative phosphorylation, accompanied by a reduction in inflammatory markers. Our results show that finasteride is associated with a reduction in plasma cholesterol in both human and mice and highlight the potential role of this drug in the reduction of atherosclerosis."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/114110"],"dc:language":["en","eng"],"dc:rights":["Copyright 2021 James McQueen"],"dc:subject":["Nutritional science"],"dc:title":["Finasteride lowers cholesterol in humans and delays atherosclerosis progression in Ldlr-/- mice"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:54Z"}