{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/114076"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/114076","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Assessment of the impact of early life trauma, changes in estrogen signaling, and neurotoxic molecules in a mouse model of multiple sclerosis","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","abstract_has_math":false,"creators":["Khaw, Yee Ming"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":["Ko, Chemyong","Steelman, Andrew J","McKim, Daniel B","Inoue, Makoto"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-04-29T21:58:26Z","date_published":"2022-04-29T21:58:26Z","updated_at":"2026-07-22T22:24:54Z","subjects":["Neuroscience"],"languages":["en","eng"],"rights":["Copyright 2021 Yee Ming Khaw"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/114076","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Ko, Chemyong","Steelman, Andrew J","McKim, Daniel B","Inoue, Makoto"]},{"key":"dc:creator","label":"Author","values":["Khaw, Yee Ming"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-04-29T21:58:26Z","2024-04-29T21:58:46Z","2021-12","2021-11-29"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Yee Ming Khaw"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/114076"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","The student, Yee Ming Khaw, accepted the attached license on 2021-11-22 at 21:30.","The student, Yee Ming Khaw, submitted this Dissertation for approval on 2021-11-22 at 21:35.","This Dissertation was approved for publication on 2021-11-29 at 13:08.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17241 on 2022-04-29 at 16:09:54","Made available in DSpace on 2022-04-29T21:58:26Z (GMT). No. of bitstreams: 2 KHAW-DISSERTATION-2021.pdf: 12939153 bytes, checksum: 20bd55a69969ca74bccc0938f77b5d07 (MD5) LICENSE.txt: 4210 bytes, checksum: c9858f5823dbb06f2b9ad93bb363e451 (MD5) Previous issue date: 2021-11-29","Embargo set by: Seth Robbins for item 123441 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","Multiple sclerosis (MS) is the most common neurological disease that affect young adults that causes the accumulation of disability over time due to irreversible neurodegeneration. Disease presentations vary significantly from person to person in terms of who gets the disease, who develops the more severe types of MS, the type of central nervous system injury that the disease inflicts, molecular signatures on disease driving immune cells, and one’s sensitivity to prescribed treatment. While it is a deeply heterogenous disease, MS is widely accepted to be driven by an autoimmune response characterized by the infiltration of peripheral immune cells and activation of CNS-resident glial cells which results in demyelination, loss of oligodendrocytes, neuron atrophy. The etiology of MS is undetermined. Several genetic and non-genetic (a.k.a. environmental) factors have been identified to have significant impact on disease activity and its underlying mechanism. Importantly, evidence suggest that non-genetic environmental factors play a significant role in disease modification by acting on cellular drivers of the disease. Herein, using a MS model of experimental autoimmune encephalomyelitis (EAE) in four independent projects, I report that non-genetic environmental factors of early life stress, changes in estrogen level, immune cell expression of neurotoxic molecule contribute to disease heterogeneity. The studies also highlight the identity of membrane lymphotoxin-lymphotoxin receptor beta receptor signaling and CXCR2 signaling as potential biomarkers for neurodegenerative and interferon-beta resistant MS and EAE."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Assessment of the impact of early life trauma, changes in estrogen signaling, and neurotoxic molecules in a mouse model of multiple sclerosis"]}]}],"canonical_facts":{"dc:contributor":["Ko, Chemyong","Steelman, Andrew J","McKim, Daniel B","Inoue, Makoto"],"dc:creator":["Khaw, Yee Ming"],"dc:date":["2022-04-29T21:58:26Z","2024-04-29T21:58:46Z","2021-12","2021-11-29"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","The student, Yee Ming Khaw, accepted the attached license on 2021-11-22 at 21:30.","The student, Yee Ming Khaw, submitted this Dissertation for approval on 2021-11-22 at 21:35.","This Dissertation was approved for publication on 2021-11-29 at 13:08.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17241 on 2022-04-29 at 16:09:54","Made available in DSpace on 2022-04-29T21:58:26Z (GMT). No. of bitstreams: 2 KHAW-DISSERTATION-2021.pdf: 12939153 bytes, checksum: 20bd55a69969ca74bccc0938f77b5d07 (MD5) LICENSE.txt: 4210 bytes, checksum: c9858f5823dbb06f2b9ad93bb363e451 (MD5) Previous issue date: 2021-11-29","Embargo set by: Seth Robbins for item 123441 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","Multiple sclerosis (MS) is the most common neurological disease that affect young adults that causes the accumulation of disability over time due to irreversible neurodegeneration. Disease presentations vary significantly from person to person in terms of who gets the disease, who develops the more severe types of MS, the type of central nervous system injury that the disease inflicts, molecular signatures on disease driving immune cells, and one’s sensitivity to prescribed treatment. While it is a deeply heterogenous disease, MS is widely accepted to be driven by an autoimmune response characterized by the infiltration of peripheral immune cells and activation of CNS-resident glial cells which results in demyelination, loss of oligodendrocytes, neuron atrophy. The etiology of MS is undetermined. Several genetic and non-genetic (a.k.a. environmental) factors have been identified to have significant impact on disease activity and its underlying mechanism. Importantly, evidence suggest that non-genetic environmental factors play a significant role in disease modification by acting on cellular drivers of the disease. Herein, using a MS model of experimental autoimmune encephalomyelitis (EAE) in four independent projects, I report that non-genetic environmental factors of early life stress, changes in estrogen level, immune cell expression of neurotoxic molecule contribute to disease heterogeneity. The studies also highlight the identity of membrane lymphotoxin-lymphotoxin receptor beta receptor signaling and CXCR2 signaling as potential biomarkers for neurodegenerative and interferon-beta resistant MS and EAE."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/114076"],"dc:language":["en","eng"],"dc:rights":["Copyright 2021 Yee Ming Khaw"],"dc:subject":["Neuroscience"],"dc:title":["Assessment of the impact of early life trauma, changes in estrogen signaling, and neurotoxic molecules in a mouse model of multiple sclerosis"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:54Z"}