{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/114035"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/114035","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Study of alternative splicing events associated with hyperalgesia","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","abstract_has_math":false,"creators":["Perez, Olivia C."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Rodriguez-Zas, Sandra L","Southey, Bruce","Villamil, Maria B"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-04-29T21:58:12Z","date_published":"2022-04-29T21:58:12Z","updated_at":"2026-07-22T22:24:54Z","subjects":["Opioid-induced hyperalgesia","alternative splicing","trigeminal ganglia","nucleus accumbens"],"languages":["en","eng"],"rights":["Copyright 2021 Olivia Perez"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/114035","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Rodriguez-Zas, Sandra L","Southey, Bruce","Villamil, Maria B"]},{"key":"dc:creator","label":"Author","values":["Perez, Olivia C."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-04-29T21:58:12Z","2024-04-29T21:58:46Z","2021-12","2021-08-03"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Opioid-induced hyperalgesia","alternative splicing","trigeminal ganglia","nucleus accumbens"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Olivia Perez"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/114035"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","The student, Olivia Perez, accepted the attached license on 2021-07-20 at 18:17.","The student, Olivia Perez, submitted this Thesis for approval on 2021-07-27 at 10:01.","This Thesis was approved for publication on 2021-08-03 at 13:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17036 on 2022-04-29 at 16:08:46","Made available in DSpace on 2022-04-29T21:58:12Z (GMT). No. of bitstreams: 2 PEREZ-THESIS-2021.pdf: 719193 bytes, checksum: a4d9bec6030f633ec977de746fea0c9a (MD5) LICENSE.txt: 4209 bytes, checksum: 48cef40d290069ea04358dbeff49c47f (MD5) Previous issue date: 2021-08-03","Embargo set by: Seth Robbins for item 123400 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","Prolonged use of opioids could cause oversensitivity to stimuli and opioid-induced hyperalgesia (OIH). Despite reports of differential gene expression associated with OIH and known alternative splicing of these differentially expressed genes, the impact of alternative splicing on OIH remains partially characterized. Alternative splicing mechanisms were studied to gain a comprehensive understanding of the effects of alternative splicing on OIH elicited by chronic morphine exposure. The characterization of alternative splicing in the trigeminal ganglia and nucleus accumbens of mice enabled the identification of region-dependent splicing mechanisms underlying OIH. Genes that participate in glutamatergic synapse and myelin protein processes presented splicing mechanism associated with OIH. A prevalence of alternative splicing events associated with OIH was identify in the platelet derived growth factor, axon guidance, and integrin signaling pathways. A notable finding was the prevalence of alternatively spliced transcription factors and enriched transcriptional regulators. Our study offered insights into the nociceptive and antinociceptive modulatory action of alternatively spliced genes. The results from our study highlight the impact of alternative splicing mechanisms and transcriptional regulators associated with OIH. These findings enhance the accuracy of OIH therapeutic target studies."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Study of alternative splicing events associated with hyperalgesia"]}]}],"canonical_facts":{"dc:contributor":["Rodriguez-Zas, Sandra L","Southey, Bruce","Villamil, Maria B"],"dc:creator":["Perez, Olivia C."],"dc:date":["2022-04-29T21:58:12Z","2024-04-29T21:58:46Z","2021-12","2021-08-03"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01","The student, Olivia Perez, accepted the attached license on 2021-07-20 at 18:17.","The student, Olivia Perez, submitted this Thesis for approval on 2021-07-27 at 10:01.","This Thesis was approved for publication on 2021-08-03 at 13:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17036 on 2022-04-29 at 16:08:46","Made available in DSpace on 2022-04-29T21:58:12Z (GMT). No. of bitstreams: 2 PEREZ-THESIS-2021.pdf: 719193 bytes, checksum: a4d9bec6030f633ec977de746fea0c9a (MD5) LICENSE.txt: 4209 bytes, checksum: 48cef40d290069ea04358dbeff49c47f (MD5) Previous issue date: 2021-08-03","Embargo set by: Seth Robbins for item 123400 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","Prolonged use of opioids could cause oversensitivity to stimuli and opioid-induced hyperalgesia (OIH). Despite reports of differential gene expression associated with OIH and known alternative splicing of these differentially expressed genes, the impact of alternative splicing on OIH remains partially characterized. Alternative splicing mechanisms were studied to gain a comprehensive understanding of the effects of alternative splicing on OIH elicited by chronic morphine exposure. The characterization of alternative splicing in the trigeminal ganglia and nucleus accumbens of mice enabled the identification of region-dependent splicing mechanisms underlying OIH. Genes that participate in glutamatergic synapse and myelin protein processes presented splicing mechanism associated with OIH. A prevalence of alternative splicing events associated with OIH was identify in the platelet derived growth factor, axon guidance, and integrin signaling pathways. A notable finding was the prevalence of alternatively spliced transcription factors and enriched transcriptional regulators. Our study offered insights into the nociceptive and antinociceptive modulatory action of alternatively spliced genes. The results from our study highlight the impact of alternative splicing mechanisms and transcriptional regulators associated with OIH. These findings enhance the accuracy of OIH therapeutic target studies."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/114035"],"dc:language":["en","eng"],"dc:rights":["Copyright 2021 Olivia Perez"],"dc:subject":["Opioid-induced hyperalgesia","alternative splicing","trigeminal ganglia","nucleus accumbens"],"dc:title":["Study of alternative splicing events associated with hyperalgesia"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:54Z"}