{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113933"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113933","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Cortical bone growth in response to local strain environment","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms","abstract_has_math":false,"creators":["Manandhar, Sony"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":["Kersh, Mariana Elizabeth"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-04-29T21:35:54Z","date_published":"2022-04-29T21:35:54Z","updated_at":"2026-07-22T22:24:53Z","subjects":["Mechanical science"],"languages":["en","eng"],"rights":["Copyright 2021 Sony Manandhar"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113933","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kersh, Mariana Elizabeth"]},{"key":"dc:creator","label":"Author","values":["Manandhar, Sony"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-04-29T21:35:54Z","2021-12","2021-12-10"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mechanical science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Sony Manandhar"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113933"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms","The student, Sony Manandhar, accepted the attached license on 2021-12-09 at 18:14.","The student, Sony Manandhar, submitted this Thesis for approval on 2021-12-09 at 18:28.","This Thesis was approved for publication on 2021-12-10 at 14:13.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17444 on 2022-04-06 at 17:11:17","Made available in DSpace on 2022-04-29T21:35:54Z (GMT). No. of bitstreams: 2 MANANDHAR-THESIS-2021.pdf: 20574430 bytes, checksum: e95afe96f47ea1cb5d54ee1a64e3c0ea (MD5) LICENSE.txt: 4211 bytes, checksum: bc7ce4c79dae55279b70801b0a374e24 (MD5) Previous issue date: 2021-12-10","Osteoporosis is a disease characterized by skeletal fragility resulting in increased risk of fracture. Millions of people are affected by osteoporotic fractures every year. Pharmaceutical drugs available in the current market have side-effects coming from long-term administration and adherence. While mechanical loading is known to be a critical factor during cortical bone growth, the type of mechanical loading a bone is subjected to during normal physiological condition can also affect bone development process. It still is unclear whether tensile or compressive strains have better outcome in young cortical bone growth. In this study, juvenile sheep femur were scanned using micro-Computed Tomography (CT). Thickness and density were computed via image processing in MATLAB. Bone volume fraction (BV/TV) was determined through image processing in Amira. Samples along the longitudinal axis of diaphysis were machined and mechanically tested in three-point bending. Mechanical testing was done in two con figurations: stain mode specific (SMS) (testing samples in habitual loading) and non-strain mode specific (testing samples in loading they are normally subjected to). Structure, composition, and material properties were investigated in two specific quadrants of femur diaphysis: anterior side subjected to tensile loading, and posterior side subjected to compressive loading during physiological activities. There was no significant difference between cortical thickness and density of anterior and posterior quadrants. BV/TV was significantly higher in anterior quadrant compared to posterior quadrant in proximal diaphysis (p=0.016). Flexural modulus of anterior quadrant was higher than posterior only in distal diaphysis when tested in non-SMS condition (p=8E- 3). Anterior quadrant was always stronger than posterior quadrant regardless of testing mode (SMS: p=8E-3 proximal and middle diaphysis, non-SMS: p=8E-3 middle and distal diaphysis). Poor correlation was detected between density-modulus and density-strength (R2 = 7.6% and R2 = 11.3% respectively). BV/TV was more important in explaining the material properties than density: BV/TV-modulus R2 = 10.7% and BV/TV-strength R2 = 30.7%."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Cortical bone growth in response to local strain environment"]}]}],"canonical_facts":{"dc:contributor":["Kersh, Mariana Elizabeth"],"dc:creator":["Manandhar, Sony"],"dc:date":["2022-04-29T21:35:54Z","2021-12","2021-12-10"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms","The student, Sony Manandhar, accepted the attached license on 2021-12-09 at 18:14.","The student, Sony Manandhar, submitted this Thesis for approval on 2021-12-09 at 18:28.","This Thesis was approved for publication on 2021-12-10 at 14:13.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17444 on 2022-04-06 at 17:11:17","Made available in DSpace on 2022-04-29T21:35:54Z (GMT). No. of bitstreams: 2 MANANDHAR-THESIS-2021.pdf: 20574430 bytes, checksum: e95afe96f47ea1cb5d54ee1a64e3c0ea (MD5) LICENSE.txt: 4211 bytes, checksum: bc7ce4c79dae55279b70801b0a374e24 (MD5) Previous issue date: 2021-12-10","Osteoporosis is a disease characterized by skeletal fragility resulting in increased risk of fracture. Millions of people are affected by osteoporotic fractures every year. Pharmaceutical drugs available in the current market have side-effects coming from long-term administration and adherence. While mechanical loading is known to be a critical factor during cortical bone growth, the type of mechanical loading a bone is subjected to during normal physiological condition can also affect bone development process. It still is unclear whether tensile or compressive strains have better outcome in young cortical bone growth. In this study, juvenile sheep femur were scanned using micro-Computed Tomography (CT). Thickness and density were computed via image processing in MATLAB. Bone volume fraction (BV/TV) was determined through image processing in Amira. Samples along the longitudinal axis of diaphysis were machined and mechanically tested in three-point bending. Mechanical testing was done in two con figurations: stain mode specific (SMS) (testing samples in habitual loading) and non-strain mode specific (testing samples in loading they are normally subjected to). Structure, composition, and material properties were investigated in two specific quadrants of femur diaphysis: anterior side subjected to tensile loading, and posterior side subjected to compressive loading during physiological activities. There was no significant difference between cortical thickness and density of anterior and posterior quadrants. BV/TV was significantly higher in anterior quadrant compared to posterior quadrant in proximal diaphysis (p=0.016). Flexural modulus of anterior quadrant was higher than posterior only in distal diaphysis when tested in non-SMS condition (p=8E- 3). Anterior quadrant was always stronger than posterior quadrant regardless of testing mode (SMS: p=8E-3 proximal and middle diaphysis, non-SMS: p=8E-3 middle and distal diaphysis). Poor correlation was detected between density-modulus and density-strength (R2 = 7.6% and R2 = 11.3% respectively). BV/TV was more important in explaining the material properties than density: BV/TV-modulus R2 = 10.7% and BV/TV-strength R2 = 30.7%."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/113933"],"dc:language":["en","eng"],"dc:rights":["Copyright 2021 Sony Manandhar"],"dc:subject":["Mechanical science"],"dc:title":["Cortical bone growth in response to local strain environment"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Mechanical Engineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:53Z"}