{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113249"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113249","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Development of the MRC-SPECT-II system: a MR-compatible small-animal SPECT system based on semiconductor imaging spectrometers and a Synthetic Compound-Eye gamma camera design","abstract":"Single photon emission computed tomography (SPECT) is a routine molecular imaging modality, widely appreciated in any nuclear medicine department and clinically used for more than 50 years. Whereas SPECT instrumentation used in clinical and preclinical practice is still mainly based on cumbersome scintillation detectors, characterized by poor energy and spatial resolution, the demand of high-performance SPECT instrumentation continues to rise. We have designed and fully developed the second-generation of a Magnetic Resonance (MR)-Compatible SPECT system, the MRC-SPECT-II system, a high-performance SPECT scanner designed for preclinical imaging applications. The stationary system consists of a full ring of compact semiconductor detectors coupled with a complex collimator aperture, to be integrated inside small-bore pre-clinical MRI scanners. The system is based on two key features: a small-pixel ultra-high resolution solid-state detector module and an innovative geometry named Synthetic Compound-Eye gamma camera, bioinspired to compound eyes often found as vision system in small invertebrates. Preliminary studies demonstrate that the proposed system offers an unprecedented spectroscopic performance (1.71 ± 0.28 keV at 122 keV) in a broad energy range, making it well-suited for multi-isotope SPECT imaging and hyperspectral imaging applications. The prototype achieves a peak geometrical sensitivity of ~0.33%, consistently greater than 0.25% across the central field-of-view of 3.5 cm D × 2.5 cm L. From imaging reconstruction, the prototype offers sub-1-mm spatial resolution when used as standalone SPECT system. To demonstrate that the combination of ultrahigh-resolution imaging spectrometers and the Synthetic Compound-Eye gamma camera design would greatly benefit future clinical SPECT imaging systems, we present the conceptual design study of a brain SPECT imaging system. We prove that the novel system design coupled with non-conventional aperture designs, namely micro-slits and micro-rings, could provide an excellent spatial resolution (<4 mm), a very high sensitivity (up to 1.38%), and a rich angular sampling without scanning motion over a clinically relevant field-of-view of 20 cm in diameter.","abstract_html":"Single photon emission computed tomography (SPECT) is a routine molecular imaging modality, widely appreciated in any nuclear medicine department and clinically used for more than 50 years. Whereas SPECT instrumentation used in clinical and preclinical practice is still mainly based on cumbersome scintillation detectors, characterized by poor energy and spatial resolution, the demand of high-performance SPECT instrumentation continues to rise. We have designed and fully developed the second-generation of a Magnetic Resonance (MR)-Compatible SPECT system, the MRC-SPECT-II system, a high-performance SPECT scanner designed for preclinical imaging applications. The stationary system consists of a full ring of compact semiconductor detectors coupled with a complex collimator aperture, to be integrated inside small-bore pre-clinical MRI scanners. The system is based on two key features: a small-pixel ultra-high resolution solid-state detector module and an innovative geometry named Synthetic Compound-Eye gamma camera, bioinspired to compound eyes often found as vision system in small invertebrates. Preliminary studies demonstrate that the proposed system offers an unprecedented spectroscopic performance (1.71 ± 0.28 keV at 122 keV) in a broad energy range, making it well-suited for multi-isotope SPECT imaging and hyperspectral imaging applications. The prototype achieves a peak geometrical sensitivity of ~0.33%, consistently greater than 0.25% across the central field-of-view of 3.5 cm D × 2.5 cm L. From imaging reconstruction, the prototype offers sub-1-mm spatial resolution when used as standalone SPECT system. To demonstrate that the combination of ultrahigh-resolution imaging spectrometers and the Synthetic Compound-Eye gamma camera design would greatly benefit future clinical SPECT imaging systems, we present the conceptual design study of a brain SPECT imaging system. We prove that the novel system design coupled with non-conventional aperture designs, namely micro-slits and micro-rings, could provide an excellent spatial resolution (&lt;4 mm), a very high sensitivity (up to 1.38%), and a rich angular sampling without scanning motion over a clinically relevant field-of-view of 20 cm in diameter.","abstract_has_math":false,"creators":["Zannoni, Elena Maria"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Meng, Ling-Jian","Insana, Michael","Dobrucki, Wawrzyniec","La Rivière, Patrick J","Tai, Yuan-Chuan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-01-12T22:51:37Z","date_published":"2022-01-12T22:51:37Z","updated_at":"2026-07-22T22:24:53Z","subjects":["semiconductor detector","imaging system development","nuclear imaging","hyperspectral imaging","SPECT/MRI"],"languages":["en"],"rights":["Copyright 2021 Elena Maria Zannoni"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113249","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Meng, Ling-Jian","Insana, Michael","Dobrucki, Wawrzyniec","La Rivière, Patrick J","Tai, Yuan-Chuan"]},{"key":"dc:creator","label":"Author","values":["Zannoni, Elena Maria"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-01-12T22:51:37Z","2024-01-12T22:56:20Z","2021-06-21","2021-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["semiconductor detector","imaging system development","nuclear imaging","hyperspectral imaging","SPECT/MRI"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Elena Maria Zannoni"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113249"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Single photon emission computed tomography (SPECT) is a routine molecular imaging modality, widely appreciated in any nuclear medicine department and clinically used for more than 50 years. Whereas SPECT instrumentation used in clinical and preclinical practice is still mainly based on cumbersome scintillation detectors, characterized by poor energy and spatial resolution, the demand of high-performance SPECT instrumentation continues to rise. We have designed and fully developed the second-generation of a Magnetic Resonance (MR)-Compatible SPECT system, the MRC-SPECT-II system, a high-performance SPECT scanner designed for preclinical imaging applications. The stationary system consists of a full ring of compact semiconductor detectors coupled with a complex collimator aperture, to be integrated inside small-bore pre-clinical MRI scanners. The system is based on two key features: a small-pixel ultra-high resolution solid-state detector module and an innovative geometry named Synthetic Compound-Eye gamma camera, bioinspired to compound eyes often found as vision system in small invertebrates. Preliminary studies demonstrate that the proposed system offers an unprecedented spectroscopic performance (1.71 ± 0.28 keV at 122 keV) in a broad energy range, making it well-suited for multi-isotope SPECT imaging and hyperspectral imaging applications. The prototype achieves a peak geometrical sensitivity of ~0.33%, consistently greater than 0.25% across the central field-of-view of 3.5 cm D × 2.5 cm L. From imaging reconstruction, the prototype offers sub-1-mm spatial resolution when used as standalone SPECT system. To demonstrate that the combination of ultrahigh-resolution imaging spectrometers and the Synthetic Compound-Eye gamma camera design would greatly benefit future clinical SPECT imaging systems, we present the conceptual design study of a brain SPECT imaging system. We prove that the novel system design coupled with non-conventional aperture designs, namely micro-slits and micro-rings, could provide an excellent spatial resolution (<4 mm), a very high sensitivity (up to 1.38%), and a rich angular sampling without scanning motion over a clinically relevant field-of-view of 20 cm in diameter.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01","The student, Elena Maria Zannoni, accepted the attached license on 2021-06-15 at 20:01.","The student, Elena Maria Zannoni, submitted this Dissertation for approval on 2021-06-15 at 20:16.","This Dissertation was approved for publication on 2021-06-21 at 10:03.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16691 on 2022-01-12 at 13:03:17","Made available in DSpace on 2022-01-12T22:51:37Z (GMT). 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Whereas SPECT instrumentation used in clinical and preclinical practice is still mainly based on cumbersome scintillation detectors, characterized by poor energy and spatial resolution, the demand of high-performance SPECT instrumentation continues to rise. We have designed and fully developed the second-generation of a Magnetic Resonance (MR)-Compatible SPECT system, the MRC-SPECT-II system, a high-performance SPECT scanner designed for preclinical imaging applications. The stationary system consists of a full ring of compact semiconductor detectors coupled with a complex collimator aperture, to be integrated inside small-bore pre-clinical MRI scanners. The system is based on two key features: a small-pixel ultra-high resolution solid-state detector module and an innovative geometry named Synthetic Compound-Eye gamma camera, bioinspired to compound eyes often found as vision system in small invertebrates. Preliminary studies demonstrate that the proposed system offers an unprecedented spectroscopic performance (1.71 ± 0.28 keV at 122 keV) in a broad energy range, making it well-suited for multi-isotope SPECT imaging and hyperspectral imaging applications. The prototype achieves a peak geometrical sensitivity of ~0.33%, consistently greater than 0.25% across the central field-of-view of 3.5 cm D × 2.5 cm L. From imaging reconstruction, the prototype offers sub-1-mm spatial resolution when used as standalone SPECT system. To demonstrate that the combination of ultrahigh-resolution imaging spectrometers and the Synthetic Compound-Eye gamma camera design would greatly benefit future clinical SPECT imaging systems, we present the conceptual design study of a brain SPECT imaging system. We prove that the novel system design coupled with non-conventional aperture designs, namely micro-slits and micro-rings, could provide an excellent spatial resolution (<4 mm), a very high sensitivity (up to 1.38%), and a rich angular sampling without scanning motion over a clinically relevant field-of-view of 20 cm in diameter.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01","The student, Elena Maria Zannoni, accepted the attached license on 2021-06-15 at 20:01.","The student, Elena Maria Zannoni, submitted this Dissertation for approval on 2021-06-15 at 20:16.","This Dissertation was approved for publication on 2021-06-21 at 10:03.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16691 on 2022-01-12 at 13:03:17","Made available in DSpace on 2022-01-12T22:51:37Z (GMT). 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