{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113248"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113248","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Translational optical coherence tomography for quantitative assessments of eardrum biomechanics, effusions, and biofilm response during otitis media","abstract":"Author requested closed access (OA after 2yrs) in Vireo ETD system","abstract_html":"Author requested closed access (OA after 2yrs) in Vireo ETD system","abstract_has_math":false,"creators":["Won, Jungeun"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Boppart, Stephen A.","Do, Minh","Lu, Ting","Porter, Ryan G."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-01-12T22:51:37Z","date_published":"2022-01-12T22:51:37Z","updated_at":"2026-07-22T22:24:53Z","subjects":["Biofilm","biophotonics","middle ear","optical coherence tomography","optical imaging","otitis media","tympanic membrane"],"languages":["en"],"rights":["Copyright 2021 Jungeun Won"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113248","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Boppart, Stephen A.","Do, Minh","Lu, Ting","Porter, Ryan G."]},{"key":"dc:creator","label":"Author","values":["Won, Jungeun"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-01-12T22:51:37Z","2024-01-12T22:56:20Z","2021-07-07","2021-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biofilm","biophotonics","middle ear","optical coherence tomography","optical imaging","otitis media","tympanic membrane"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Jungeun Won"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113248"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","A middle ear infection, also known as otitis media (OM), is a prevalent pediatric disease caused by bacteria or viral pathogens in the middle ear. OM is clinically characterized by a presence of a middle ear effusion (MEE), accumulated fluid in a normally air-filled middle ear cavity. The persistent MEEs can lead to temporary hearing loss. Unfortunately, one out of three acute OM cases come back and repeated in young children. Previous studies showed that a bacterial biofilm, aggregated bacteria embedded within a slimy matrix in the middle ear, may be responsible for recurrent and chronic OM. However, current diagnostic technologies in non-invasively examining the middle ear cavity are limited. The standard tool, an otoscope, illuminates and magnifies the surface view of an eardrum, but assessing the MEEs and biofilms behind the semi-opaque eardrum during OM is challenging. Recent studies have integrated an advanced optical imaging technique, called optical coherence tomography (OCT), into a handheld probe to non-invasively provide cross-sectional visualization of the middle ear cavity, and showed that OCT can identify and quantify the eardrum thickness, the presence of the MEEs and biofilms, which were correlated with clinical diagnosis. This dissertation takes the next step and establishes: 1) dynamic measurements of the eardrum mobility, 2) optical characterization and biological correlation of the MEEs in humans and in an OM-induced animal model, 3) in vivo monitoring of middle ear biofilms to antibiotic therapy, 4) development of a compact OCT device integrated with an automated classifier, and 5) investigation of a new therapeutic method for OM using cold plasma. Collectively, these results demonstrate new technologies that non-invasively provide quantitative and clinically relevant information inside the middle ear during OM, and form a bridge that links engineering and biomedicine in OM research for further translation.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01","The student, Jungeun Won, accepted the attached license on 2021-06-15 at 11:48.","The student, Jungeun Won, submitted this Dissertation for approval on 2021-06-15 at 12:03.","This Dissertation was approved for publication on 2021-07-07 at 08:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16689 on 2022-01-12 at 13:03:08","Made available in DSpace on 2022-01-12T22:51:37Z (GMT). No. of bitstreams: 3 WON-DISSERTATION-2021.pdf: 12816858 bytes, checksum: 0ebd4d4874f28ec0c0206b847a3cfc9a (MD5) PhDthesis_v7.5_mendref.docx: 70793646 bytes, checksum: 7c87e2a3e5c18982b022f10b0e8737ad (MD5) LICENSE.txt: 4208 bytes, checksum: fc4ac6263860aef3493c3258a22ef412 (MD5) Previous issue date: 2021-07-07","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:51:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:53:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:54:14Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:55:09Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:56:20Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Translational optical coherence tomography for quantitative assessments of eardrum biomechanics, effusions, and biofilm response during otitis media"]}]}],"canonical_facts":{"dc:contributor":["Boppart, Stephen A.","Do, Minh","Lu, Ting","Porter, Ryan G."],"dc:creator":["Won, Jungeun"],"dc:date":["2022-01-12T22:51:37Z","2024-01-12T22:56:20Z","2021-07-07","2021-08"],"dc:description":["Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited","A middle ear infection, also known as otitis media (OM), is a prevalent pediatric disease caused by bacteria or viral pathogens in the middle ear. OM is clinically characterized by a presence of a middle ear effusion (MEE), accumulated fluid in a normally air-filled middle ear cavity. The persistent MEEs can lead to temporary hearing loss. Unfortunately, one out of three acute OM cases come back and repeated in young children. Previous studies showed that a bacterial biofilm, aggregated bacteria embedded within a slimy matrix in the middle ear, may be responsible for recurrent and chronic OM. However, current diagnostic technologies in non-invasively examining the middle ear cavity are limited. The standard tool, an otoscope, illuminates and magnifies the surface view of an eardrum, but assessing the MEEs and biofilms behind the semi-opaque eardrum during OM is challenging. Recent studies have integrated an advanced optical imaging technique, called optical coherence tomography (OCT), into a handheld probe to non-invasively provide cross-sectional visualization of the middle ear cavity, and showed that OCT can identify and quantify the eardrum thickness, the presence of the MEEs and biofilms, which were correlated with clinical diagnosis. This dissertation takes the next step and establishes: 1) dynamic measurements of the eardrum mobility, 2) optical characterization and biological correlation of the MEEs in humans and in an OM-induced animal model, 3) in vivo monitoring of middle ear biofilms to antibiotic therapy, 4) development of a compact OCT device integrated with an automated classifier, and 5) investigation of a new therapeutic method for OM using cold plasma. Collectively, these results demonstrate new technologies that non-invasively provide quantitative and clinically relevant information inside the middle ear during OM, and form a bridge that links engineering and biomedicine in OM research for further translation.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01","The student, Jungeun Won, accepted the attached license on 2021-06-15 at 11:48.","The student, Jungeun Won, submitted this Dissertation for approval on 2021-06-15 at 12:03.","This Dissertation was approved for publication on 2021-07-07 at 08:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16689 on 2022-01-12 at 13:03:08","Made available in DSpace on 2022-01-12T22:51:37Z (GMT). No. of bitstreams: 3 WON-DISSERTATION-2021.pdf: 12816858 bytes, checksum: 0ebd4d4874f28ec0c0206b847a3cfc9a (MD5) PhDthesis_v7.5_mendref.docx: 70793646 bytes, checksum: 7c87e2a3e5c18982b022f10b0e8737ad (MD5) LICENSE.txt: 4208 bytes, checksum: fc4ac6263860aef3493c3258a22ef412 (MD5) Previous issue date: 2021-07-07","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:51:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:53:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:54:14Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:55:09Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 121174 Lift date: 2024-01-12T22:56:20Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/113248"],"dc:language":["en"],"dc:rights":["Copyright 2021 Jungeun Won"],"dc:subject":["Biofilm","biophotonics","middle ear","optical coherence tomography","optical imaging","otitis media","tympanic membrane"],"dc:title":["Translational optical coherence tomography for quantitative assessments of eardrum biomechanics, effusions, and biofilm response during otitis media"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Bioengineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:53Z"}