{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113238"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113238","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Ion current modulation in bio-mimetic channel systems","abstract":"Ion channels form information processing in living cells by facilitating electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires synthetic ion channels that can alter their conductance in response to various external manipulations. And the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to the ionic current modulation by removable peptide gating in nanopore (FraC), which has the application in biomedical engineering fields such as recognition amino acid sequence and analysis of amino acids and their post-translational modifications for therapeutic purposes. The all-atom simulation models of studying ABA copolymer gating mechanism and a mechanosensitive channel (MscL) gated by thermo-mechanical sensitive ABA copolymer membrane. These works represent potential applications of drug delivery engineering. The nanopore sequencing system by using various mutant CsgG to sense different DNA sequences. Several factors affect the ionic current in nanopore channels, including the shape of the channel, the different DNA nucleotides’ packing geometry, the electroosmotic flow (EOF) in nanopores. These works represent potential applications of improving nanopore sequencing distinguishability.","abstract_html":"Ion channels form information processing in living cells by facilitating electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires synthetic ion channels that can alter their conductance in response to various external manipulations. And the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to the ionic current modulation by removable peptide gating in nanopore (FraC), which has the application in biomedical engineering fields such as recognition amino acid sequence and analysis of amino acids and their post-translational modifications for therapeutic purposes. The all-atom simulation models of studying ABA copolymer gating mechanism and a mechanosensitive channel (MscL) gated by thermo-mechanical sensitive ABA copolymer membrane. These works represent potential applications of drug delivery engineering. The nanopore sequencing system by using various mutant CsgG to sense different DNA sequences. Several factors affect the ionic current in nanopore channels, including the shape of the channel, the different DNA nucleotides’ packing geometry, the electroosmotic flow (EOF) in nanopores. These works represent potential applications of improving nanopore sequencing distinguishability.","abstract_has_math":false,"creators":["Zhao, Shidi"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biophysics & Quant Biology","degree_department":null,"school":null,"contributors":["Aksimentiev, Aleksei","Grosman, Claudio","Shukla, Diwakar","Pogorelov, Taras"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-01-12T22:51:34Z","date_published":"2022-01-12T22:51:34Z","updated_at":"2026-07-22T22:24:53Z","subjects":["ion channels, MD simulation"],"languages":["en"],"rights":["Copyright 2021 Shidi Zhao"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113238","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Aksimentiev, Aleksei","Grosman, Claudio","Shukla, Diwakar","Pogorelov, Taras"]},{"key":"dc:creator","label":"Author","values":["Zhao, Shidi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-01-12T22:51:34Z","2024-01-12T22:56:20Z","2021-06-18","2021-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biophysics & Quant Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ion channels, MD simulation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Shidi Zhao"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113238"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ion channels form information processing in living cells by facilitating electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires synthetic ion channels that can alter their conductance in response to various external manipulations. And the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to the ionic current modulation by removable peptide gating in nanopore (FraC), which has the application in biomedical engineering fields such as recognition amino acid sequence and analysis of amino acids and their post-translational modifications for therapeutic purposes. The all-atom simulation models of studying ABA copolymer gating mechanism and a mechanosensitive channel (MscL) gated by thermo-mechanical sensitive ABA copolymer membrane. These works represent potential applications of drug delivery engineering. The nanopore sequencing system by using various mutant CsgG to sense different DNA sequences. Several factors affect the ionic current in nanopore channels, including the shape of the channel, the different DNA nucleotides’ packing geometry, the electroosmotic flow (EOF) in nanopores. These works represent potential applications of improving nanopore sequencing distinguishability.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01","The student, Shidi Zhao, accepted the attached license on 2021-05-25 at 23:07.","The student, Shidi Zhao, submitted this Dissertation for approval on 2021-05-25 at 23:14.","This Dissertation was approved for publication on 2021-06-18 at 10:48.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16636 on 2022-01-12 at 13:02:53","Made available in DSpace on 2022-01-12T22:51:34Z (GMT). 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Applying the same principles to man-made systems requires synthetic ion channels that can alter their conductance in response to various external manipulations. And the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to the ionic current modulation by removable peptide gating in nanopore (FraC), which has the application in biomedical engineering fields such as recognition amino acid sequence and analysis of amino acids and their post-translational modifications for therapeutic purposes. The all-atom simulation models of studying ABA copolymer gating mechanism and a mechanosensitive channel (MscL) gated by thermo-mechanical sensitive ABA copolymer membrane. These works represent potential applications of drug delivery engineering. The nanopore sequencing system by using various mutant CsgG to sense different DNA sequences. Several factors affect the ionic current in nanopore channels, including the shape of the channel, the different DNA nucleotides’ packing geometry, the electroosmotic flow (EOF) in nanopores. These works represent potential applications of improving nanopore sequencing distinguishability.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01","The student, Shidi Zhao, accepted the attached license on 2021-05-25 at 23:07.","The student, Shidi Zhao, submitted this Dissertation for approval on 2021-05-25 at 23:14.","This Dissertation was approved for publication on 2021-06-18 at 10:48.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16636 on 2022-01-12 at 13:02:53","Made available in DSpace on 2022-01-12T22:51:34Z (GMT). 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