{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113084"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113084","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The effects of per- and polyfluoroalkyl substances (PFAS) and high fat diet on metabolism, reproductive health & prostate cancer progression","abstract":"Per- and polyfluoroalkyl substances (PFASs) are a group of synthetic chemicals that have been utilized in various industries and settings. Their resistance to water, oil, grease, and extreme temperatures enabled utilization of PFAS in adhesives, cleaning-products, paints, coatings, packaging, building materials, and firefighting foams. Due to highly fluorinated carbon chains ranging in length, PFAS are resistant to decomposition, and have increased longevity in media, such as soil, water, dust, and air. Because of increased stability in the environment, many communities in the US are exposed to high concentration of PFAS. Multiple studies reported increased PFAS blood concentrations in fluorochemical factory workers, office workers, and firefighters, all of which are exposed to these materials on a day-to-day basis. Epidemiological studies linked PFAS exposures to increased risk of various pathological conditions including non-alcoholic fatty liver disease, infertility, and cancer. Epidemiological studies suggested a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism of action for such a phenomenon is unknown. In the present thesis research, we investigated how PFAS impacts prostate cancer metabolism, progression, and prognosis. We tested the hypothesis that metabolic alterations from high fat diets combined with PFAS exposures play a significant role in prostate cancer initiation and tumor progression.","abstract_html":"Per- and polyfluoroalkyl substances (PFASs) are a group of synthetic chemicals that have been utilized in various industries and settings. Their resistance to water, oil, grease, and extreme temperatures enabled utilization of PFAS in adhesives, cleaning-products, paints, coatings, packaging, building materials, and firefighting foams. Due to highly fluorinated carbon chains ranging in length, PFAS are resistant to decomposition, and have increased longevity in media, such as soil, water, dust, and air. Because of increased stability in the environment, many communities in the US are exposed to high concentration of PFAS. Multiple studies reported increased PFAS blood concentrations in fluorochemical factory workers, office workers, and firefighters, all of which are exposed to these materials on a day-to-day basis. Epidemiological studies linked PFAS exposures to increased risk of various pathological conditions including non-alcoholic fatty liver disease, infertility, and cancer. Epidemiological studies suggested a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism of action for such a phenomenon is unknown. In the present thesis research, we investigated how PFAS impacts prostate cancer metabolism, progression, and prognosis. We tested the hypothesis that metabolic alterations from high fat diets combined with PFAS exposures play a significant role in prostate cancer initiation and tumor progression.","abstract_has_math":false,"creators":["Imir, Ozan Berk"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Madak-Erdogan, Zeynep","Flaws, Jodi A","Irudayaraj, Joseph MK"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-01-12T21:46:58Z","date_published":"2022-01-12T21:46:58Z","updated_at":"2026-07-22T22:24:53Z","subjects":["cancer","prostate","perfluoroalkyl substance"],"languages":["en"],"rights":["Copyright 2021 Ozan Berk Imir"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113084","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Madak-Erdogan, Zeynep","Flaws, Jodi A","Irudayaraj, Joseph MK"]},{"key":"dc:creator","label":"Author","values":["Imir, Ozan Berk"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-01-12T21:46:58Z","2021-07-21","2021-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cancer","prostate","perfluoroalkyl substance"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Ozan Berk Imir"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113084"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Per- and polyfluoroalkyl substances (PFASs) are a group of synthetic chemicals that have been utilized in various industries and settings. Their resistance to water, oil, grease, and extreme temperatures enabled utilization of PFAS in adhesives, cleaning-products, paints, coatings, packaging, building materials, and firefighting foams. Due to highly fluorinated carbon chains ranging in length, PFAS are resistant to decomposition, and have increased longevity in media, such as soil, water, dust, and air. Because of increased stability in the environment, many communities in the US are exposed to high concentration of PFAS. Multiple studies reported increased PFAS blood concentrations in fluorochemical factory workers, office workers, and firefighters, all of which are exposed to these materials on a day-to-day basis. Epidemiological studies linked PFAS exposures to increased risk of various pathological conditions including non-alcoholic fatty liver disease, infertility, and cancer. Epidemiological studies suggested a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism of action for such a phenomenon is unknown. In the present thesis research, we investigated how PFAS impacts prostate cancer metabolism, progression, and prognosis. We tested the hypothesis that metabolic alterations from high fat diets combined with PFAS exposures play a significant role in prostate cancer initiation and tumor progression.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo terms","The student, Ozan Imir, accepted the attached license on 2021-07-21 at 08:57.","The student, Ozan Imir, submitted this Thesis for approval on 2021-07-21 at 09:06.","This Thesis was approved for publication on 2021-07-21 at 13:24.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17041 on 2022-01-12 at 12:46:32","Made available in DSpace on 2022-01-12T21:46:58Z (GMT). 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Their resistance to water, oil, grease, and extreme temperatures enabled utilization of PFAS in adhesives, cleaning-products, paints, coatings, packaging, building materials, and firefighting foams. Due to highly fluorinated carbon chains ranging in length, PFAS are resistant to decomposition, and have increased longevity in media, such as soil, water, dust, and air. Because of increased stability in the environment, many communities in the US are exposed to high concentration of PFAS. Multiple studies reported increased PFAS blood concentrations in fluorochemical factory workers, office workers, and firefighters, all of which are exposed to these materials on a day-to-day basis. Epidemiological studies linked PFAS exposures to increased risk of various pathological conditions including non-alcoholic fatty liver disease, infertility, and cancer. Epidemiological studies suggested a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism of action for such a phenomenon is unknown. In the present thesis research, we investigated how PFAS impacts prostate cancer metabolism, progression, and prognosis. We tested the hypothesis that metabolic alterations from high fat diets combined with PFAS exposures play a significant role in prostate cancer initiation and tumor progression.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo terms","The student, Ozan Imir, accepted the attached license on 2021-07-21 at 08:57.","The student, Ozan Imir, submitted this Thesis for approval on 2021-07-21 at 09:06.","This Thesis was approved for publication on 2021-07-21 at 13:24.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17041 on 2022-01-12 at 12:46:32","Made available in DSpace on 2022-01-12T21:46:58Z (GMT). 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