{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113065"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113065","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Methodology for quantitative assessment of perfusion in porcine model of peripheral arterial disease","abstract":"Peripheral artery disease (PAD) is the degradation of perfusion in the lower muscles caused by the narrowing of upstream arteries. Currently, the diagnosis and prognosis of the disease rely almost entirely on hemodynamic metrics of major vessels affecting the periphery. Quantitative assessment of peripheral perfusion within muscles of impaired microcirculation is required to improve the understanding of the disease process and surpass the existing limitations in clinical practice. The aim of this study is two-fold. First, I will review recent advancements made in perfusion imaging modalities by providing detailed information about the methods and metrics used for PAD diagnosis and treatment. In the second part, I will describe a revised protocol for applying the gold-standard method for 3D perfusion quantification and mapping the peripheral skeletal musculature with fluorescent microspheres. The defined workflow could provide a reliable way to calibrate other perfusion imaging modalities and foster an understanding of PAD mechanisms.","abstract_html":"Peripheral artery disease (PAD) is the degradation of perfusion in the lower muscles caused by the narrowing of upstream arteries. Currently, the diagnosis and prognosis of the disease rely almost entirely on hemodynamic metrics of major vessels affecting the periphery. Quantitative assessment of peripheral perfusion within muscles of impaired microcirculation is required to improve the understanding of the disease process and surpass the existing limitations in clinical practice. The aim of this study is two-fold. First, I will review recent advancements made in perfusion imaging modalities by providing detailed information about the methods and metrics used for PAD diagnosis and treatment. In the second part, I will describe a revised protocol for applying the gold-standard method for 3D perfusion quantification and mapping the peripheral skeletal musculature with fluorescent microspheres. The defined workflow could provide a reliable way to calibrate other perfusion imaging modalities and foster an understanding of PAD mechanisms.","abstract_has_math":false,"creators":["Pinot, Leopold Jean Baptiste"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Dobrucki, Wawrzyniec L"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-01-12T21:46:53Z","date_published":"2022-01-12T21:46:53Z","updated_at":"2026-07-22T22:24:53Z","subjects":["peripheral arterial disease","diagnosis","therapy","imaging modalities","perfusion","fluorescent microspheres","review","methodology"],"languages":["en"],"rights":["Copyright 2021 Leopold Pinot"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113065","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dobrucki, Wawrzyniec L"]},{"key":"dc:creator","label":"Author","values":["Pinot, Leopold Jean Baptiste"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-01-12T21:46:53Z","2021-07-19","2021-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["peripheral arterial disease","diagnosis","therapy","imaging modalities","perfusion","fluorescent microspheres","review","methodology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Leopold Pinot"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113065"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Peripheral artery disease (PAD) is the degradation of perfusion in the lower muscles caused by the narrowing of upstream arteries. Currently, the diagnosis and prognosis of the disease rely almost entirely on hemodynamic metrics of major vessels affecting the periphery. Quantitative assessment of peripheral perfusion within muscles of impaired microcirculation is required to improve the understanding of the disease process and surpass the existing limitations in clinical practice. The aim of this study is two-fold. First, I will review recent advancements made in perfusion imaging modalities by providing detailed information about the methods and metrics used for PAD diagnosis and treatment. In the second part, I will describe a revised protocol for applying the gold-standard method for 3D perfusion quantification and mapping the peripheral skeletal musculature with fluorescent microspheres. The defined workflow could provide a reliable way to calibrate other perfusion imaging modalities and foster an understanding of PAD mechanisms.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo terms","The student, Leopold Pinot, accepted the attached license on 2021-07-16 at 16:06.","The student, Leopold Pinot, submitted this Thesis for approval on 2021-07-16 at 16:19.","This Thesis was approved for publication on 2021-07-19 at 13:36.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16992 on 2022-01-12 at 12:46:08","Made available in DSpace on 2022-01-12T21:46:53Z (GMT). No. of bitstreams: 2 PINOT-THESIS-2021.pdf: 1179685 bytes, checksum: dc973289509d49c09f1a83fe88c376bb (MD5) LICENSE.txt: 4210 bytes, checksum: 1700fcd4ca5d4e8a7ad517d0606e31fb (MD5) Previous issue date: 2021-07-19"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Methodology for quantitative assessment of perfusion in porcine model of peripheral arterial disease"]}]}],"canonical_facts":{"dc:contributor":["Dobrucki, Wawrzyniec L"],"dc:creator":["Pinot, Leopold Jean Baptiste"],"dc:date":["2022-01-12T21:46:53Z","2021-07-19","2021-08"],"dc:description":["Peripheral artery disease (PAD) is the degradation of perfusion in the lower muscles caused by the narrowing of upstream arteries. Currently, the diagnosis and prognosis of the disease rely almost entirely on hemodynamic metrics of major vessels affecting the periphery. Quantitative assessment of peripheral perfusion within muscles of impaired microcirculation is required to improve the understanding of the disease process and surpass the existing limitations in clinical practice. The aim of this study is two-fold. First, I will review recent advancements made in perfusion imaging modalities by providing detailed information about the methods and metrics used for PAD diagnosis and treatment. In the second part, I will describe a revised protocol for applying the gold-standard method for 3D perfusion quantification and mapping the peripheral skeletal musculature with fluorescent microspheres. The defined workflow could provide a reliable way to calibrate other perfusion imaging modalities and foster an understanding of PAD mechanisms.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo terms","The student, Leopold Pinot, accepted the attached license on 2021-07-16 at 16:06.","The student, Leopold Pinot, submitted this Thesis for approval on 2021-07-16 at 16:19.","This Thesis was approved for publication on 2021-07-19 at 13:36.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16992 on 2022-01-12 at 12:46:08","Made available in DSpace on 2022-01-12T21:46:53Z (GMT). No. of bitstreams: 2 PINOT-THESIS-2021.pdf: 1179685 bytes, checksum: dc973289509d49c09f1a83fe88c376bb (MD5) LICENSE.txt: 4210 bytes, checksum: 1700fcd4ca5d4e8a7ad517d0606e31fb (MD5) Previous issue date: 2021-07-19"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/113065"],"dc:language":["en"],"dc:rights":["Copyright 2021 Leopold Pinot"],"dc:subject":["peripheral arterial disease","diagnosis","therapy","imaging modalities","perfusion","fluorescent microspheres","review","methodology"],"dc:title":["Methodology for quantitative assessment of perfusion in porcine model of peripheral arterial disease"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Bioengineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:53Z"}