{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/113056"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/113056","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Utility of inbreeding coefficient and sire as predictors for osteochondrosis risk in Standardbred horses","abstract":"Osteochondrosis (OC) is a developmental orthopedic disease that commonly affects young Standardbred horses and often requires surgical intervention. Both environmental and complex genetic risk factors play a role in the development of OC. However, no specific risk genes have yet been identified that could be used to quantify genetic risk at the level of the individual. Sire effects on risk of OC have been reported, but inbreeding coefficient has not been examined as predictor for genetic risk of disease. We investigated this in a cohort of 910 Standardbred yearlings fluoroscopically screened for osteochondral fragments. Controls (n = 545) were defined as horses that had no osteochondral fragments in any joint. Two groups of cases were defined; those with ostechondrosis dissecans (OCD) of the hock (n = 198) and those with plantar osteochondral fragments (POF) of the fetlock (n = 167). Horses with both hock OCD and fetlock POF were excluded. Inbreeding coefficients were obtained from a publically available database. Logarithmic regression analyses were conducted for each condition, with inbreeding coefficient, gait, and sex, +/- sire as predictors. For fetlock POF, none of the predictors were statistically significant. For hock OCD, males were slightly more likely than females to be affected (p=0.015, OR 1.5, 95% CI 1.1-2.1), while sire (p=0.0002), but not inbreeding coefficient (p=0.41) was a significant predictor (Table 1). These results suggest inbreeding coefficient in and of itself cannot be considered a proxy for genetic risk for either of the investigated conditions. Further work is needed to model the genetic risk factors underlying the influence of sire in our population.","abstract_html":"Osteochondrosis (OC) is a developmental orthopedic disease that commonly affects young Standardbred horses and often requires surgical intervention. Both environmental and complex genetic risk factors play a role in the development of OC. However, no specific risk genes have yet been identified that could be used to quantify genetic risk at the level of the individual. Sire effects on risk of OC have been reported, but inbreeding coefficient has not been examined as predictor for genetic risk of disease. We investigated this in a cohort of 910 Standardbred yearlings fluoroscopically screened for osteochondral fragments. Controls (n = 545) were defined as horses that had no osteochondral fragments in any joint. Two groups of cases were defined; those with ostechondrosis dissecans (OCD) of the hock (n = 198) and those with plantar osteochondral fragments (POF) of the fetlock (n = 167). Horses with both hock OCD and fetlock POF were excluded. Inbreeding coefficients were obtained from a publically available database. Logarithmic regression analyses were conducted for each condition, with inbreeding coefficient, gait, and sex, +/- sire as predictors. For fetlock POF, none of the predictors were statistically significant. For hock OCD, males were slightly more likely than females to be affected (p=0.015, OR 1.5, 95% CI 1.1-2.1), while sire (p=0.0002), but not inbreeding coefficient (p=0.41) was a significant predictor (Table 1). These results suggest inbreeding coefficient in and of itself cannot be considered a proxy for genetic risk for either of the investigated conditions. Further work is needed to model the genetic risk factors underlying the influence of sire in our population.","abstract_has_math":false,"creators":["Baldes, Molly Marie"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Kline, Kevin H","Miller, David J","McCoy, Annette M"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-01-12T21:46:49Z","date_published":"2022-01-12T21:46:49Z","updated_at":"2026-07-22T22:24:52Z","subjects":["OC","OCD","horse, inbreeding coefficient","sire","Standardbred, osteochondrosis"],"languages":["en"],"rights":["Copyright 2021 Molly Baldes"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/113056","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kline, Kevin H","Miller, David J","McCoy, Annette M"]},{"key":"dc:creator","label":"Author","values":["Baldes, Molly Marie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-01-12T21:46:49Z","2021-07-23","2021-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["OC","OCD","horse, inbreeding coefficient","sire","Standardbred, osteochondrosis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Molly Baldes"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/113056"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Osteochondrosis (OC) is a developmental orthopedic disease that commonly affects young Standardbred horses and often requires surgical intervention. Both environmental and complex genetic risk factors play a role in the development of OC. However, no specific risk genes have yet been identified that could be used to quantify genetic risk at the level of the individual. Sire effects on risk of OC have been reported, but inbreeding coefficient has not been examined as predictor for genetic risk of disease. We investigated this in a cohort of 910 Standardbred yearlings fluoroscopically screened for osteochondral fragments. Controls (n = 545) were defined as horses that had no osteochondral fragments in any joint. Two groups of cases were defined; those with ostechondrosis dissecans (OCD) of the hock (n = 198) and those with plantar osteochondral fragments (POF) of the fetlock (n = 167). Horses with both hock OCD and fetlock POF were excluded. Inbreeding coefficients were obtained from a publically available database. Logarithmic regression analyses were conducted for each condition, with inbreeding coefficient, gait, and sex, +/- sire as predictors. For fetlock POF, none of the predictors were statistically significant. For hock OCD, males were slightly more likely than females to be affected (p=0.015, OR 1.5, 95% CI 1.1-2.1), while sire (p=0.0002), but not inbreeding coefficient (p=0.41) was a significant predictor (Table 1). These results suggest inbreeding coefficient in and of itself cannot be considered a proxy for genetic risk for either of the investigated conditions. Further work is needed to model the genetic risk factors underlying the influence of sire in our population.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo terms","The student, Molly Baldes, accepted the attached license on 2021-07-22 at 08:54.","The student, Molly Baldes, submitted this Thesis for approval on 2021-07-22 at 09:01.","This Thesis was approved for publication on 2021-07-23 at 10:27.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16961 on 2022-01-12 at 12:45:56","Made available in DSpace on 2022-01-12T21:46:49Z (GMT). No. of bitstreams: 4 BALDES-THESIS-2021.pdf: 365964 bytes, checksum: ddf2f95f2c8f6e62d3f1794049b98d4a (MD5) Baldes Thesis Grad Corrections.docx: 67146 bytes, checksum: 1a6a4b51f3a364f0da225cf20be1b361 (MD5) Baldes Thesis final corrections.docx: 59859 bytes, checksum: 2ae6c4c7b52f5e2d67fe76f1ae99a62a (MD5) LICENSE.txt: 4209 bytes, checksum: 649c6942de29cd1c0c78d6813d963f01 (MD5) Previous issue date: 2021-07-23"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Utility of inbreeding coefficient and sire as predictors for osteochondrosis risk in Standardbred horses"]}]}],"canonical_facts":{"dc:contributor":["Kline, Kevin H","Miller, David J","McCoy, Annette M"],"dc:creator":["Baldes, Molly Marie"],"dc:date":["2022-01-12T21:46:49Z","2021-07-23","2021-08"],"dc:description":["Osteochondrosis (OC) is a developmental orthopedic disease that commonly affects young Standardbred horses and often requires surgical intervention. Both environmental and complex genetic risk factors play a role in the development of OC. However, no specific risk genes have yet been identified that could be used to quantify genetic risk at the level of the individual. Sire effects on risk of OC have been reported, but inbreeding coefficient has not been examined as predictor for genetic risk of disease. We investigated this in a cohort of 910 Standardbred yearlings fluoroscopically screened for osteochondral fragments. Controls (n = 545) were defined as horses that had no osteochondral fragments in any joint. Two groups of cases were defined; those with ostechondrosis dissecans (OCD) of the hock (n = 198) and those with plantar osteochondral fragments (POF) of the fetlock (n = 167). Horses with both hock OCD and fetlock POF were excluded. Inbreeding coefficients were obtained from a publically available database. Logarithmic regression analyses were conducted for each condition, with inbreeding coefficient, gait, and sex, +/- sire as predictors. For fetlock POF, none of the predictors were statistically significant. For hock OCD, males were slightly more likely than females to be affected (p=0.015, OR 1.5, 95% CI 1.1-2.1), while sire (p=0.0002), but not inbreeding coefficient (p=0.41) was a significant predictor (Table 1). These results suggest inbreeding coefficient in and of itself cannot be considered a proxy for genetic risk for either of the investigated conditions. Further work is needed to model the genetic risk factors underlying the influence of sire in our population.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-01-12 without embargo terms","The student, Molly Baldes, accepted the attached license on 2021-07-22 at 08:54.","The student, Molly Baldes, submitted this Thesis for approval on 2021-07-22 at 09:01.","This Thesis was approved for publication on 2021-07-23 at 10:27.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16961 on 2022-01-12 at 12:45:56","Made available in DSpace on 2022-01-12T21:46:49Z (GMT). No. of bitstreams: 4 BALDES-THESIS-2021.pdf: 365964 bytes, checksum: ddf2f95f2c8f6e62d3f1794049b98d4a (MD5) Baldes Thesis Grad Corrections.docx: 67146 bytes, checksum: 1a6a4b51f3a364f0da225cf20be1b361 (MD5) Baldes Thesis final corrections.docx: 59859 bytes, checksum: 2ae6c4c7b52f5e2d67fe76f1ae99a62a (MD5) LICENSE.txt: 4209 bytes, checksum: 649c6942de29cd1c0c78d6813d963f01 (MD5) Previous issue date: 2021-07-23"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/113056"],"dc:language":["en"],"dc:rights":["Copyright 2021 Molly Baldes"],"dc:subject":["OC","OCD","horse, inbreeding coefficient","sire","Standardbred, osteochondrosis"],"dc:title":["Utility of inbreeding coefficient and sire as predictors for osteochondrosis risk in Standardbred horses"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:52Z"}