{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/110698"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/110698","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Single-chain polymeric systems: design, synthesis, and applications","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01","abstract_has_math":false,"creators":["Garcia Ramirez, Edzna Shunay"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Zimmerman, Steven C","Harley, Brendan A","Moore, Jeffrey S","Schroeder, Charles M"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-09-17T02:34:37Z","date_published":"2021-09-17T02:34:37Z","updated_at":"2026-07-22T22:24:52Z","subjects":["single-chain polymer","amphiphilic polymer","catalysis","allyl carbamate cleavage"],"languages":["en"],"rights":["Copyright 2021 Edzna Garcia Ramirez"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/110698","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zimmerman, Steven C","Harley, Brendan A","Moore, Jeffrey S","Schroeder, Charles M"]},{"key":"dc:creator","label":"Author","values":["Garcia Ramirez, Edzna Shunay"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-09-17T02:34:37Z","2023-09-17T02:34:57Z","2021-04-20","2021-05"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["single-chain polymer","amphiphilic polymer","catalysis","allyl carbamate cleavage"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2021 Edzna Garcia Ramirez"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/110698"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01","The student, Edzna Garcia Ramirez, accepted the attached license on 2021-04-19 at 13:43.","The student, Edzna Garcia Ramirez, submitted this Dissertation for approval on 2021-04-19 at 14:01.","This Dissertation was approved for publication on 2021-04-20 at 16:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16413 on 2021-09-16 at 17:04:00","Single-chain polymeric nanoparticles (SCNPs) have been explored for applications in biomedicine such as drug delivery, catalysis, and imaging. These SCNPs are generated from the intramolecular folding or collapse of the single-chain polymer where the collapse is achieved by self-assembly or covalent crosslinking. In this thesis, the intramolecular self-assembly of single-chain polymeric systems is explored in catalysis and fluorescence. In Chapter 2, we developed an amphiphilic ruthenium-containing single-chain polymer that promotes allyl carbamate cleavage reactions in aqueous and biologically relevant conditions. This polymeric catalyst works in synergy with the enzyme β-galactosidase to perform a tandem reaction on a single substrate. Additionally, the polymer catalyst was characterized by various methods to study its self-assembly. In Chapter 3, we investigated a modular approach to SCNPs for catalysis that consists of an amphiphilic single-chain polymer that folds under dilute aqueous conditions resulting in unimolecular micelle-like structures. This modular approach allows binding of various catalysts and substrates leading to reaction rate enhancement. In Chapter 4, we developed fluorophore-containing single-chain polymers that may be useful in bioimaging. The polymers solubilized and stabilized various types of organic fluorophores leading to brighter and more stable fluorophores.","Made available in DSpace on 2021-09-17T02:34:37Z (GMT). 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These SCNPs are generated from the intramolecular folding or collapse of the single-chain polymer where the collapse is achieved by self-assembly or covalent crosslinking. In this thesis, the intramolecular self-assembly of single-chain polymeric systems is explored in catalysis and fluorescence. In Chapter 2, we developed an amphiphilic ruthenium-containing single-chain polymer that promotes allyl carbamate cleavage reactions in aqueous and biologically relevant conditions. This polymeric catalyst works in synergy with the enzyme β-galactosidase to perform a tandem reaction on a single substrate. Additionally, the polymer catalyst was characterized by various methods to study its self-assembly. In Chapter 3, we investigated a modular approach to SCNPs for catalysis that consists of an amphiphilic single-chain polymer that folds under dilute aqueous conditions resulting in unimolecular micelle-like structures. This modular approach allows binding of various catalysts and substrates leading to reaction rate enhancement. In Chapter 4, we developed fluorophore-containing single-chain polymers that may be useful in bioimaging. The polymers solubilized and stabilized various types of organic fluorophores leading to brighter and more stable fluorophores.","Made available in DSpace on 2021-09-17T02:34:37Z (GMT). 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