{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/109607"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/109607","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Magnetomotive optical coherence tomography and elastography with applications in magnetic thermotherapy dosimetry","abstract":"Magnetic nanoparticles (MNPs), with their versatility, have raised extensive interest in the field of biomedicine. MNPs can be delivered to the tumors as therapeutic agents in magnetic thermotherapy (MT) to ablate the malignancies. Remotely manipulated with an external magnetic field, the same MNPs can also induce “magnetomotions”, which can be detected via magnetomotive optical coherence tomography (MM-OCT) and enable biomechanical characterization with magnetomotive optical coherence elastography (MM-OCE). In this thesis, the theranostic functionality of MNPs are exploited, where the biomechanical alterations of the MT-treated tissues were probed by MM-OCE; thereby providing a biophysically informative evaluation of the thermal damage. Treated with MNP hyperthermia, the elasticity changes were qualitatively measured based on the natural/resonant frequency detected by transient-response or spectroscopic MM-OCE. Interstitial MT was provided using a magnetic thermoseed, and the thermally perturbed tissue stiffness was quantified with shear-wave MM-OCE. From ex vivo porcine livers, a linear correlation between the stiffness increase and the thermal energy deposited was observed, offering physical meanings to the elasticity-based metric. In addition, in vivo MM-OCE-based elastograms were generated, for the first time, with an accelerated MM-OCE platform developed with a single chirped force excitation, rapid BM-mode scanning, and parallel-programming-based image reconstruction. Finally, the association between the tissue elasticity, the fundamental biological variations (i.e. tumor cellularity, protein conformation forms), and the MT-induced temperature rise was characterized on in vivo murine melanoma tumors. It was observed that tumors with lower cellularity can be softened after MT treatment. In contrast, depending on the temperature rise achieved and the conformation forms of the collagen fibers, highly cellular tumors can be stiffened either reversibly or irreversibly. In summary, theranostic MNPs can be delivered to the tumors and tracked by MM-OCT imaging. The MT-induced biomechanical alteration (which is related to the intrinsic biological features and molecular changes) can then also be characterized with MM-OCE.","abstract_html":"Magnetic nanoparticles (MNPs), with their versatility, have raised extensive interest in the field of biomedicine. MNPs can be delivered to the tumors as therapeutic agents in magnetic thermotherapy (MT) to ablate the malignancies. Remotely manipulated with an external magnetic field, the same MNPs can also induce “magnetomotions”, which can be detected via magnetomotive optical coherence tomography (MM-OCT) and enable biomechanical characterization with magnetomotive optical coherence elastography (MM-OCE). In this thesis, the theranostic functionality of MNPs are exploited, where the biomechanical alterations of the MT-treated tissues were probed by MM-OCE; thereby providing a biophysically informative evaluation of the thermal damage. Treated with MNP hyperthermia, the elasticity changes were qualitatively measured based on the natural/resonant frequency detected by transient-response or spectroscopic MM-OCE. Interstitial MT was provided using a magnetic thermoseed, and the thermally perturbed tissue stiffness was quantified with shear-wave MM-OCE. From ex vivo porcine livers, a linear correlation between the stiffness increase and the thermal energy deposited was observed, offering physical meanings to the elasticity-based metric. In addition, in vivo MM-OCE-based elastograms were generated, for the first time, with an accelerated MM-OCE platform developed with a single chirped force excitation, rapid BM-mode scanning, and parallel-programming-based image reconstruction. Finally, the association between the tissue elasticity, the fundamental biological variations (i.e. tumor cellularity, protein conformation forms), and the MT-induced temperature rise was characterized on in vivo murine melanoma tumors. It was observed that tumors with lower cellularity can be softened after MT treatment. In contrast, depending on the temperature rise achieved and the conformation forms of the collagen fibers, highly cellular tumors can be stiffened either reversibly or irreversibly. In summary, theranostic MNPs can be delivered to the tumors and tracked by MM-OCT imaging. The MT-induced biomechanical alteration (which is related to the intrinsic biological features and molecular changes) can then also be characterized with MM-OCE.","abstract_has_math":false,"creators":["Huang, Pin-Chieh"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Boppart, Stephen A","Insana, Michael F","Sutton, Bradley P","Sobh, Nahil A"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-03-05T21:45:39Z","date_published":"2021-03-05T21:45:39Z","updated_at":"2026-07-22T22:24:50Z","subjects":["Optical coherence tomography","Elastography","Magnetic nanoparticles","Magnetic hyperthermia"],"languages":["en"],"rights":["Copyright 2020 Pin-Chieh Huang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/109607","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Boppart, Stephen A","Insana, Michael F","Sutton, Bradley P","Sobh, Nahil A"]},{"key":"dc:creator","label":"Author","values":["Huang, Pin-Chieh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-03-05T21:45:39Z","2023-03-05T21:47:41Z","2020-12-02","2020-12"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Optical coherence tomography","Elastography","Magnetic nanoparticles","Magnetic hyperthermia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2020 Pin-Chieh Huang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/109607"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Magnetic nanoparticles (MNPs), with their versatility, have raised extensive interest in the field of biomedicine. MNPs can be delivered to the tumors as therapeutic agents in magnetic thermotherapy (MT) to ablate the malignancies. Remotely manipulated with an external magnetic field, the same MNPs can also induce “magnetomotions”, which can be detected via magnetomotive optical coherence tomography (MM-OCT) and enable biomechanical characterization with magnetomotive optical coherence elastography (MM-OCE). In this thesis, the theranostic functionality of MNPs are exploited, where the biomechanical alterations of the MT-treated tissues were probed by MM-OCE; thereby providing a biophysically informative evaluation of the thermal damage. Treated with MNP hyperthermia, the elasticity changes were qualitatively measured based on the natural/resonant frequency detected by transient-response or spectroscopic MM-OCE. Interstitial MT was provided using a magnetic thermoseed, and the thermally perturbed tissue stiffness was quantified with shear-wave MM-OCE. From ex vivo porcine livers, a linear correlation between the stiffness increase and the thermal energy deposited was observed, offering physical meanings to the elasticity-based metric. In addition, in vivo MM-OCE-based elastograms were generated, for the first time, with an accelerated MM-OCE platform developed with a single chirped force excitation, rapid BM-mode scanning, and parallel-programming-based image reconstruction. Finally, the association between the tissue elasticity, the fundamental biological variations (i.e. tumor cellularity, protein conformation forms), and the MT-induced temperature rise was characterized on in vivo murine melanoma tumors. It was observed that tumors with lower cellularity can be softened after MT treatment. In contrast, depending on the temperature rise achieved and the conformation forms of the collagen fibers, highly cellular tumors can be stiffened either reversibly or irreversibly. In summary, theranostic MNPs can be delivered to the tumors and tracked by MM-OCT imaging. The MT-induced biomechanical alteration (which is related to the intrinsic biological features and molecular changes) can then also be characterized with MM-OCE.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-12-01","The student, Pin-Chieh Huang, accepted the attached license on 2020-11-28 at 20:17.","The student, Pin-Chieh Huang, submitted this Dissertation for approval on 2020-11-28 at 20:34.","This Dissertation was approved for publication on 2020-12-02 at 10:48.","DSpace SAF Submission Ingestion Package generated from Vireo submission #15977 on 2021-03-04 at 16:32:40","Made available in DSpace on 2021-03-05T21:45:39Z (GMT). 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MNPs can be delivered to the tumors as therapeutic agents in magnetic thermotherapy (MT) to ablate the malignancies. Remotely manipulated with an external magnetic field, the same MNPs can also induce “magnetomotions”, which can be detected via magnetomotive optical coherence tomography (MM-OCT) and enable biomechanical characterization with magnetomotive optical coherence elastography (MM-OCE). In this thesis, the theranostic functionality of MNPs are exploited, where the biomechanical alterations of the MT-treated tissues were probed by MM-OCE; thereby providing a biophysically informative evaluation of the thermal damage. Treated with MNP hyperthermia, the elasticity changes were qualitatively measured based on the natural/resonant frequency detected by transient-response or spectroscopic MM-OCE. Interstitial MT was provided using a magnetic thermoseed, and the thermally perturbed tissue stiffness was quantified with shear-wave MM-OCE. From ex vivo porcine livers, a linear correlation between the stiffness increase and the thermal energy deposited was observed, offering physical meanings to the elasticity-based metric. In addition, in vivo MM-OCE-based elastograms were generated, for the first time, with an accelerated MM-OCE platform developed with a single chirped force excitation, rapid BM-mode scanning, and parallel-programming-based image reconstruction. Finally, the association between the tissue elasticity, the fundamental biological variations (i.e. tumor cellularity, protein conformation forms), and the MT-induced temperature rise was characterized on in vivo murine melanoma tumors. It was observed that tumors with lower cellularity can be softened after MT treatment. In contrast, depending on the temperature rise achieved and the conformation forms of the collagen fibers, highly cellular tumors can be stiffened either reversibly or irreversibly. In summary, theranostic MNPs can be delivered to the tumors and tracked by MM-OCT imaging. The MT-induced biomechanical alteration (which is related to the intrinsic biological features and molecular changes) can then also be characterized with MM-OCE.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-12-01","The student, Pin-Chieh Huang, accepted the attached license on 2020-11-28 at 20:17.","The student, Pin-Chieh Huang, submitted this Dissertation for approval on 2020-11-28 at 20:34.","This Dissertation was approved for publication on 2020-12-02 at 10:48.","DSpace SAF Submission Ingestion Package generated from Vireo submission #15977 on 2021-03-04 at 16:32:40","Made available in DSpace on 2021-03-05T21:45:39Z (GMT). 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