{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/108624"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/108624","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Nanoporous dialysis membrane for microfluidic neural probes","abstract":"Understanding the functionality of neural circuits is important for not only research but also the development of novel treatment of neurological disorders. As the communication between cells in the brain is mainly via neurochemicals, the detection of neurochemicals is vital to understand brain functionality. Neural probes, as a microscale implant for brains, can be used to detect the neurochemicals. Among various kinds of neural probes, dialysis neural probes have high spatial resolution, but they are limited by low temporal resolution. In order to improve temporal resolution, the dialysis process needs to be faster where molecules transport through the dialysis membrane on the neural probe. The thesis focuses on the fabrication, transfer, and characterization of two potential candidates, nanoporous graphene membrane and nanoporous silicon membrane, for the dialysis membrane in a neural probe. For both membranes, after the process of fabrication and transfer, the intactness is inspected. Nanoporous graphene membranes have a non-uniform nanoporous pattern and many defects. Nanoporous silicon membranes have a uniform pattern, and the membranes after transfer can be suspended over a hole with size of 37×37 μm^2. For nanoporous silicon membranes, the mechanical strength and adhesion to the substrate are tested with penetration into agar, which has strength similar to that of mouse brain. After four penetrations, the intactness of nanoporous silicon membranes is barely degraded, and the membranes are at the same positions as before the test. Nanoporous silicon membranes are used as the dialysis membranes for methyl orange in aqueous solution. The diffusion coefficient of methyl orange is 1.45×10^(-8) cm^2/s. The fabrication and characterization of nanoporous membranes in the thesis will help lead to the integration of the dialysis membranes onto neural probes, which will aid in understanding the functionality of neural circuits.","abstract_html":"Understanding the functionality of neural circuits is important for not only research but also the development of novel treatment of neurological disorders. As the communication between cells in the brain is mainly via neurochemicals, the detection of neurochemicals is vital to understand brain functionality. Neural probes, as a microscale implant for brains, can be used to detect the neurochemicals. Among various kinds of neural probes, dialysis neural probes have high spatial resolution, but they are limited by low temporal resolution. In order to improve temporal resolution, the dialysis process needs to be faster where molecules transport through the dialysis membrane on the neural probe. The thesis focuses on the fabrication, transfer, and characterization of two potential candidates, nanoporous graphene membrane and nanoporous silicon membrane, for the dialysis membrane in a neural probe. For both membranes, after the process of fabrication and transfer, the intactness is inspected. Nanoporous graphene membranes have a non-uniform nanoporous pattern and many defects. Nanoporous silicon membranes have a uniform pattern, and the membranes after transfer can be suspended over a hole with size of 37×37 μm^2. For nanoporous silicon membranes, the mechanical strength and adhesion to the substrate are tested with penetration into agar, which has strength similar to that of mouse brain. After four penetrations, the intactness of nanoporous silicon membranes is barely degraded, and the membranes are at the same positions as before the test. Nanoporous silicon membranes are used as the dialysis membranes for methyl orange in aqueous solution. The diffusion coefficient of methyl orange is 1.45×10^(-8) cm^2/s. The fabrication and characterization of nanoporous membranes in the thesis will help lead to the integration of the dialysis membranes onto neural probes, which will aid in understanding the functionality of neural circuits.","abstract_has_math":false,"creators":["Yan, Yifei"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Vlasov, Yurii"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-10-07T22:44:41Z","date_published":"2020-10-07T22:44:41Z","updated_at":"2026-07-22T22:24:48Z","subjects":["Nanoporous membrane","Dialysis","Graphene","Silicon"],"languages":["en"],"rights":["Copyright 2020 Yifei Yan"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/108624","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Vlasov, Yurii"]},{"key":"dc:creator","label":"Author","values":["Yan, Yifei"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2020-10-07T22:44:41Z","2022-10-07T22:44:53Z","2020-07-20","2020-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Nanoporous membrane","Dialysis","Graphene","Silicon"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2020 Yifei Yan"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/108624"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Understanding the functionality of neural circuits is important for not only research but also the development of novel treatment of neurological disorders. As the communication between cells in the brain is mainly via neurochemicals, the detection of neurochemicals is vital to understand brain functionality. Neural probes, as a microscale implant for brains, can be used to detect the neurochemicals. Among various kinds of neural probes, dialysis neural probes have high spatial resolution, but they are limited by low temporal resolution. In order to improve temporal resolution, the dialysis process needs to be faster where molecules transport through the dialysis membrane on the neural probe. The thesis focuses on the fabrication, transfer, and characterization of two potential candidates, nanoporous graphene membrane and nanoporous silicon membrane, for the dialysis membrane in a neural probe. For both membranes, after the process of fabrication and transfer, the intactness is inspected. Nanoporous graphene membranes have a non-uniform nanoporous pattern and many defects. Nanoporous silicon membranes have a uniform pattern, and the membranes after transfer can be suspended over a hole with size of 37×37 μm^2. For nanoporous silicon membranes, the mechanical strength and adhesion to the substrate are tested with penetration into agar, which has strength similar to that of mouse brain. After four penetrations, the intactness of nanoporous silicon membranes is barely degraded, and the membranes are at the same positions as before the test. Nanoporous silicon membranes are used as the dialysis membranes for methyl orange in aqueous solution. The diffusion coefficient of methyl orange is 1.45×10^(-8) cm^2/s. The fabrication and characterization of nanoporous membranes in the thesis will help lead to the integration of the dialysis membranes onto neural probes, which will aid in understanding the functionality of neural circuits.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-08-01","The student, Yifei Yan, accepted the attached license on 2020-07-16 at 14:06.","The student, Yifei Yan, submitted this Thesis for approval on 2020-07-16 at 14:28.","This Thesis was approved for publication on 2020-07-20 at 09:53.","DSpace SAF Submission Ingestion Package generated from Vireo submission #15657 on 2020-10-02 at 15:33:44","Made available in DSpace on 2020-10-07T22:44:41Z (GMT). No. of bitstreams: 2 YAN-THESIS-2020.pdf: 41291675 bytes, checksum: 99092b7659c5c135f6b1271d86cebd77 (MD5) LICENSE.txt: 4206 bytes, checksum: 57ed613be57097671514a4e938bfcf59 (MD5) Previous issue date: 2020-07-20","Embargo set by: Seth Robbins for item 116251 Lift date: 2022-10-07T22:44:53Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Nanoporous dialysis membrane for microfluidic neural probes"]}]}],"canonical_facts":{"dc:contributor":["Vlasov, Yurii"],"dc:creator":["Yan, Yifei"],"dc:date":["2020-10-07T22:44:41Z","2022-10-07T22:44:53Z","2020-07-20","2020-08"],"dc:description":["Understanding the functionality of neural circuits is important for not only research but also the development of novel treatment of neurological disorders. As the communication between cells in the brain is mainly via neurochemicals, the detection of neurochemicals is vital to understand brain functionality. Neural probes, as a microscale implant for brains, can be used to detect the neurochemicals. Among various kinds of neural probes, dialysis neural probes have high spatial resolution, but they are limited by low temporal resolution. In order to improve temporal resolution, the dialysis process needs to be faster where molecules transport through the dialysis membrane on the neural probe. The thesis focuses on the fabrication, transfer, and characterization of two potential candidates, nanoporous graphene membrane and nanoporous silicon membrane, for the dialysis membrane in a neural probe. For both membranes, after the process of fabrication and transfer, the intactness is inspected. Nanoporous graphene membranes have a non-uniform nanoporous pattern and many defects. Nanoporous silicon membranes have a uniform pattern, and the membranes after transfer can be suspended over a hole with size of 37×37 μm^2. For nanoporous silicon membranes, the mechanical strength and adhesion to the substrate are tested with penetration into agar, which has strength similar to that of mouse brain. After four penetrations, the intactness of nanoporous silicon membranes is barely degraded, and the membranes are at the same positions as before the test. Nanoporous silicon membranes are used as the dialysis membranes for methyl orange in aqueous solution. The diffusion coefficient of methyl orange is 1.45×10^(-8) cm^2/s. The fabrication and characterization of nanoporous membranes in the thesis will help lead to the integration of the dialysis membranes onto neural probes, which will aid in understanding the functionality of neural circuits.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-08-01","The student, Yifei Yan, accepted the attached license on 2020-07-16 at 14:06.","The student, Yifei Yan, submitted this Thesis for approval on 2020-07-16 at 14:28.","This Thesis was approved for publication on 2020-07-20 at 09:53.","DSpace SAF Submission Ingestion Package generated from Vireo submission #15657 on 2020-10-02 at 15:33:44","Made available in DSpace on 2020-10-07T22:44:41Z (GMT). No. of bitstreams: 2 YAN-THESIS-2020.pdf: 41291675 bytes, checksum: 99092b7659c5c135f6b1271d86cebd77 (MD5) LICENSE.txt: 4206 bytes, checksum: 57ed613be57097671514a4e938bfcf59 (MD5) Previous issue date: 2020-07-20","Embargo set by: Seth Robbins for item 116251 Lift date: 2022-10-07T22:44:53Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/108624"],"dc:language":["en"],"dc:rights":["Copyright 2020 Yifei Yan"],"dc:subject":["Nanoporous membrane","Dialysis","Graphene","Silicon"],"dc:title":["Nanoporous dialysis membrane for microfluidic neural probes"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Electrical & Computer Engr"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:48Z"}