{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/108149"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/108149","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Hard and soft coatings on gold nanoparticles at the nano-bio interface","abstract":"This dissertation explores surface chemistry of gold nanoparticles, with a special focus in developing analytical methods to decipher the environment of small molecule ligands and biomolecule coronas at the molecular level. Chapter 1 introduces the physical and chemical properties of gold nanoparticles and recent advancement on elucidating the surface chemistry and protein corona formation of gold nanorods. Chapter 2 and Chapter 3 probe nanoparticle systems at the molecular level with NMR techniques. Chapter 2 details the development of a solution NMR based approach, including chemical shift analysis, ligand density analysis, and T2 relaxation analysis, to explore the environment of a small molecule thiol ligand on gold nanospheres and gold nanorods. In Chapter 3, functional groups that are associated with the fluorescence origin and photobleaching of various carbon dot samples are identified by NMR spectroscopy. Chapter 4 describes how the silica porosity, silica thickness and ligand thickness impact the thermal reshaping behavior of silica coated gold nanorods. Chapter 5 explores the driven intermolecular forces in protein corona formation and the orientation of the protein corona on gold nanoparticles by an adapted BCA assay and limited proteolysis.","abstract_html":"This dissertation explores surface chemistry of gold nanoparticles, with a special focus in developing analytical methods to decipher the environment of small molecule ligands and biomolecule coronas at the molecular level. Chapter 1 introduces the physical and chemical properties of gold nanoparticles and recent advancement on elucidating the surface chemistry and protein corona formation of gold nanorods. Chapter 2 and Chapter 3 probe nanoparticle systems at the molecular level with NMR techniques. Chapter 2 details the development of a solution NMR based approach, including chemical shift analysis, ligand density analysis, and T2 relaxation analysis, to explore the environment of a small molecule thiol ligand on gold nanospheres and gold nanorods. In Chapter 3, functional groups that are associated with the fluorescence origin and photobleaching of various carbon dot samples are identified by NMR spectroscopy. Chapter 4 describes how the silica porosity, silica thickness and ligand thickness impact the thermal reshaping behavior of silica coated gold nanorods. Chapter 5 explores the driven intermolecular forces in protein corona formation and the orientation of the protein corona on gold nanoparticles by an adapted BCA assay and limited proteolysis.","abstract_has_math":false,"creators":["Wu, Meng"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Murphy, Catherine J.","Chan, Jefferson","Leal, Cecilia","Lu, Yi"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-08-26T23:58:37Z","date_published":"2020-08-26T23:58:37Z","updated_at":"2026-07-22T22:24:47Z","subjects":["Gold nanoparticles, NMR, ligand environment, protein corona."],"languages":["en"],"rights":["Copyright 2020 Meng Wu"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/108149","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Murphy, Catherine J.","Chan, Jefferson","Leal, Cecilia","Lu, Yi"]},{"key":"dc:creator","label":"Author","values":["Wu, Meng"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2020-08-26T23:58:37Z","2022-08-26T23:58:55Z","2020-05-04","2020-05"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Gold nanoparticles, NMR, ligand environment, protein corona."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2020 Meng Wu"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/108149"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This dissertation explores surface chemistry of gold nanoparticles, with a special focus in developing analytical methods to decipher the environment of small molecule ligands and biomolecule coronas at the molecular level. Chapter 1 introduces the physical and chemical properties of gold nanoparticles and recent advancement on elucidating the surface chemistry and protein corona formation of gold nanorods. Chapter 2 and Chapter 3 probe nanoparticle systems at the molecular level with NMR techniques. Chapter 2 details the development of a solution NMR based approach, including chemical shift analysis, ligand density analysis, and T2 relaxation analysis, to explore the environment of a small molecule thiol ligand on gold nanospheres and gold nanorods. In Chapter 3, functional groups that are associated with the fluorescence origin and photobleaching of various carbon dot samples are identified by NMR spectroscopy. Chapter 4 describes how the silica porosity, silica thickness and ligand thickness impact the thermal reshaping behavior of silica coated gold nanorods. Chapter 5 explores the driven intermolecular forces in protein corona formation and the orientation of the protein corona on gold nanoparticles by an adapted BCA assay and limited proteolysis.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-05-01","The student, Meng Wu, accepted the attached license on 2020-05-04 at 07:30.","The student, Meng Wu, submitted this Dissertation for approval on 2020-05-04 at 07:31.","This Dissertation was approved for publication on 2020-05-04 at 10:49.","DSpace SAF Submission Ingestion Package generated from Vireo submission #15182 on 2020-08-25 at 17:29:35","Made available in DSpace on 2020-08-26T23:58:37Z (GMT). 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Chapter 1 introduces the physical and chemical properties of gold nanoparticles and recent advancement on elucidating the surface chemistry and protein corona formation of gold nanorods. Chapter 2 and Chapter 3 probe nanoparticle systems at the molecular level with NMR techniques. Chapter 2 details the development of a solution NMR based approach, including chemical shift analysis, ligand density analysis, and T2 relaxation analysis, to explore the environment of a small molecule thiol ligand on gold nanospheres and gold nanorods. In Chapter 3, functional groups that are associated with the fluorescence origin and photobleaching of various carbon dot samples are identified by NMR spectroscopy. Chapter 4 describes how the silica porosity, silica thickness and ligand thickness impact the thermal reshaping behavior of silica coated gold nanorods. Chapter 5 explores the driven intermolecular forces in protein corona formation and the orientation of the protein corona on gold nanoparticles by an adapted BCA assay and limited proteolysis.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-05-01","The student, Meng Wu, accepted the attached license on 2020-05-04 at 07:30.","The student, Meng Wu, submitted this Dissertation for approval on 2020-05-04 at 07:31.","This Dissertation was approved for publication on 2020-05-04 at 10:49.","DSpace SAF Submission Ingestion Package generated from Vireo submission #15182 on 2020-08-25 at 17:29:35","Made available in DSpace on 2020-08-26T23:58:37Z (GMT). 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