Investigating the impact of gold nanoparticles on pulmonary cells: From 2D to 3D culture systems
type: CreativeWork
description: Nanomaterials are well-suited for a variety of applications because of their unique properties on the nanoscale. Interest in using gold nanoparticles in biological applications is growing ranging from sensing to cancer therapy due to their tunable sizes and shapes, unique optoelectronic properties, and straightforward surface modification. The advancement of fine-tuning of gold nanoparticle sizes, shapes, and surface chemistry is critical for various applications. However, many of these applications are developed in controlled environments, and not subject to the complex biological systems. Indeed, the interaction between gold nanoparticles and biological systems cannot be predicted by a single physiochemical property of nanoparticles. This interaction comes from an ensemble, combining all nanoparticle physiochemical properties and the complexity of biological systems. As a result, a fundamental understanding of how nanoparticle physiochemical properties influence biological systems is a building block for the foundation of many applications. Chapter 1 will introduce the concept of nanomaterials and their unique properties. Then syntheses and surface modification of gold nanoparticles will be introduced. These include seed-mediated growth of gold nanospheres and nanorods and the control over absolute dimensions of gold nanoparticles. Then the surface modification of gold nanoparticles, including thiol functionalization, and layer-by-layer polyelectrolyte and mesoporous silica coatings are addressed. Finally, challenges of applying nanoparticles in biological systems are discussed. Chapter 2 focuses on controlling absolute lengths and widths of gold nanorods toward tunable longitudinal localized surface plasmon resonance. Precise control over gold nanorod widths less than 10 nm accompanied by increasing gold nanorod lengths was achieved by a seed-mediated growth method. These seed-mediated growth of mini gold nanorods leads to excellent shape percent yields and > 79%…
abstract: Nanomaterials are well-suited for a variety of applications because of their unique properties on the nanoscale. Interest in using gold nanoparticles in biological applications is growing ranging from sensing to cancer therapy due to their tunable sizes and shapes, unique optoelectronic properties, and straightforward surface modification. The advancement of fine-tuning of gold nanoparticle sizes, shapes, and surface chemistry is critical for various applications. However, many of these applications are developed in controlled environments, and not subject to the complex biological systems. Indeed, the interaction between gold nanoparticles and biological systems cannot be predicted by a single physiochemical property of nanoparticles. This interaction comes from an ensemble, combining all nanoparticle physiochemical properties and the complexity of biological systems. As a result, a fundamental understanding of how nanoparticle physiochemical properties influence biological systems is a building block for the foundation of many applications. Chapter 1 will introduce the concept of nanomaterials and their unique properties. Then syntheses and surface modification of gold nanoparticles will be introduced. These include seed-mediated growth of gold nanospheres and nanorods and the control over absolute dimensions of gold nanoparticles. Then the surface modification of gold nanoparticles, including thiol functionalization, and layer-by-layer polyelectrolyte and mesoporous silica coatings are addressed. Finally, challenges of applying nanoparticles in biological systems are discussed. Chapter 2 focuses on controlling absolute lengths and widths of gold nanorods toward tunable longitudinal localized surface plasmon resonance. Precise control over gold nanorod widths less than 10 nm accompanied by increasing gold nanorod lengths was achieved by a seed-mediated growth method. These seed-mediated growth of mini gold nanorods leads to excellent shape percent yields and > 79%…
author: Chang, Huei-Huei
language: en
keywords: gold nanoparticles, seed-mediated growth, mini gold nanorods, large-scale synthesis, endocytosis, exocytosis, primary human pulmonary artery endothelial cells, gold nanoparticle aerosols, 3-dimentional human lung model, air-liquid interface, human airway epithelium differentiation
date published: 2019-11-26T20:58:35Z
date modified: 2026-07-22T22:24:45Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/105889