{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/105589"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/105589","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Developing the next-generation photoacoustic microscopy systems","abstract":"Photoacoustic imaging (PAI) is a biomedical technique 100% sensitive to optical absorption produced by either absorbing sources such as tissue or contrast agents upon laser illumination. In the past decade, photoacoustic microscopy (PAM) has advanced as a PAI technique able to image high-resolution specimens and break the optical diffusion limit reaching several millimeters in tissue depth. However, in order to implement this promising technique in real clinical scenarios it is required to refine a new generation of PAI devices which are safe, user friendly, and affordable, and which operate in vivo and in real time with fast acquisition and high sensitivity and resolution. Solving these problems vis-a-vis PAM is the main motivation behind this work. Firstly, photoacoustic shadow-casting microscopy (PASM) has been developed in our laboratory, a technique with unprecedented sensitivity that makes use of an optical absorber in contact with a biological sample and enhances the low signal-to-noise ratio originating from weak absorbers or low laser fluence when dealing with sensitive samples. As opposed to previous techniques, it is an easy and cost-effective technique that does not rely on contrast agents, averaging or increasing the laser pulse energy in order to compensate for low signal-to-noise ratio. Secondly, our current work is also explained, namely, the miniaturization of all-optical PAI systems, which is a key step toward expanding its applications such as endoscopy. In contrast to conventional piezoelectric transducers, whose miniaturization is non-trivial, the design, fabrication and implementation of all-optical methods such as whispering gallery modes or Fabry-Perot sensors meet the aforementioned requirements of the next generation of PAI systems.","abstract_html":"Photoacoustic imaging (PAI) is a biomedical technique 100% sensitive to optical absorption produced by either absorbing sources such as tissue or contrast agents upon laser illumination. In the past decade, photoacoustic microscopy (PAM) has advanced as a PAI technique able to image high-resolution specimens and break the optical diffusion limit reaching several millimeters in tissue depth. However, in order to implement this promising technique in real clinical scenarios it is required to refine a new generation of PAI devices which are safe, user friendly, and affordable, and which operate in vivo and in real time with fast acquisition and high sensitivity and resolution. Solving these problems vis-a-vis PAM is the main motivation behind this work. Firstly, photoacoustic shadow-casting microscopy (PASM) has been developed in our laboratory, a technique with unprecedented sensitivity that makes use of an optical absorber in contact with a biological sample and enhances the low signal-to-noise ratio originating from weak absorbers or low laser fluence when dealing with sensitive samples. As opposed to previous techniques, it is an easy and cost-effective technique that does not rely on contrast agents, averaging or increasing the laser pulse energy in order to compensate for low signal-to-noise ratio. Secondly, our current work is also explained, namely, the miniaturization of all-optical PAI systems, which is a key step toward expanding its applications such as endoscopy. In contrast to conventional piezoelectric transducers, whose miniaturization is non-trivial, the design, fabrication and implementation of all-optical methods such as whispering gallery modes or Fabry-Perot sensors meet the aforementioned requirements of the next generation of PAI systems.","abstract_has_math":false,"creators":["Tordera Mora, Jorge"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Gao, Liang"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-11-26T20:33:37Z","date_published":"2019-11-26T20:33:37Z","updated_at":"2026-07-22T22:24:44Z","subjects":["photoacoustic","microscopy"],"languages":["en"],"rights":["Copyright 2019 Jorge Tordera Mora"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/105589","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gao, Liang"]},{"key":"dc:creator","label":"Author","values":["Tordera Mora, Jorge"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-11-26T20:33:37Z","2019-05-31","2019-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["photoacoustic","microscopy"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2019 Jorge Tordera Mora"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/105589"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Photoacoustic imaging (PAI) is a biomedical technique 100% sensitive to optical absorption produced by either absorbing sources such as tissue or contrast agents upon laser illumination. In the past decade, photoacoustic microscopy (PAM) has advanced as a PAI technique able to image high-resolution specimens and break the optical diffusion limit reaching several millimeters in tissue depth. However, in order to implement this promising technique in real clinical scenarios it is required to refine a new generation of PAI devices which are safe, user friendly, and affordable, and which operate in vivo and in real time with fast acquisition and high sensitivity and resolution. Solving these problems vis-a-vis PAM is the main motivation behind this work. Firstly, photoacoustic shadow-casting microscopy (PASM) has been developed in our laboratory, a technique with unprecedented sensitivity that makes use of an optical absorber in contact with a biological sample and enhances the low signal-to-noise ratio originating from weak absorbers or low laser fluence when dealing with sensitive samples. As opposed to previous techniques, it is an easy and cost-effective technique that does not rely on contrast agents, averaging or increasing the laser pulse energy in order to compensate for low signal-to-noise ratio. Secondly, our current work is also explained, namely, the miniaturization of all-optical PAI systems, which is a key step toward expanding its applications such as endoscopy. In contrast to conventional piezoelectric transducers, whose miniaturization is non-trivial, the design, fabrication and implementation of all-optical methods such as whispering gallery modes or Fabry-Perot sensors meet the aforementioned requirements of the next generation of PAI systems.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2019-11-26 without embargo terms","The student, Jorge Tordera Mora, accepted the attached license on 2019-05-30 at 19:46.","The student, Jorge Tordera Mora, submitted this Thesis for approval on 2019-05-30 at 19:50.","This Thesis was approved for publication on 2019-05-31 at 11:15.","DSpace SAF Submission Ingestion Package generated from Vireo submission #14006 on 2019-11-26 at 12:49:25","Made available in DSpace on 2019-11-26T20:33:37Z (GMT). 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However, in order to implement this promising technique in real clinical scenarios it is required to refine a new generation of PAI devices which are safe, user friendly, and affordable, and which operate in vivo and in real time with fast acquisition and high sensitivity and resolution. Solving these problems vis-a-vis PAM is the main motivation behind this work. Firstly, photoacoustic shadow-casting microscopy (PASM) has been developed in our laboratory, a technique with unprecedented sensitivity that makes use of an optical absorber in contact with a biological sample and enhances the low signal-to-noise ratio originating from weak absorbers or low laser fluence when dealing with sensitive samples. As opposed to previous techniques, it is an easy and cost-effective technique that does not rely on contrast agents, averaging or increasing the laser pulse energy in order to compensate for low signal-to-noise ratio. Secondly, our current work is also explained, namely, the miniaturization of all-optical PAI systems, which is a key step toward expanding its applications such as endoscopy. In contrast to conventional piezoelectric transducers, whose miniaturization is non-trivial, the design, fabrication and implementation of all-optical methods such as whispering gallery modes or Fabry-Perot sensors meet the aforementioned requirements of the next generation of PAI systems.","Submission original under an indefinite embargo labeled 'Open Access'. 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