{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/105161"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/105161","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Elucidating the contributions of superoxide dismutases to staphylococcus aureus pathogenicity","abstract":"Bacterial infections are a leading cause of death worldwide. One disease-causing organism is Staphylococcus aureus. Despite numerous methods used by the host immune system to combat infection, S. aureus is still a major health risk. Recently, the Centers for Disease Control and Prevention and the World Health Organization listed S. aureus as one of the top threats to human health [15, 88]. The elevated threat is due to an increase of antibiotic resistant isolates and continued prevalence in the general community [15, 88], which calls for the development of new therapeutic targets to treat staphylococcal infections. In order to combat S. aureus infections, their disease causing mechanisms need to be better understood. One of the many virulence factors of S. aureus to cause disease are superoxide dismutases (SODs). In S. aureus there are two superoxide dismutases, SodA and SodM. The loss of both SODs during a retro-orbital mouse infection led to a decrease in the ability of S. aureus to cause disease [65]. However, the individual contributions of SodA and SodM to the pathogenesis of S. aureus are not completely understood. In this work I aimed to identify how SodA and SodM provide protection to S. aureus and contribute to combating nutritional immunity.","abstract_html":"Bacterial infections are a leading cause of death worldwide. One disease-causing organism is Staphylococcus aureus. Despite numerous methods used by the host immune system to combat infection, S. aureus is still a major health risk. Recently, the Centers for Disease Control and Prevention and the World Health Organization listed S. aureus as one of the top threats to human health [15, 88]. The elevated threat is due to an increase of antibiotic resistant isolates and continued prevalence in the general community [15, 88], which calls for the development of new therapeutic targets to treat staphylococcal infections. In order to combat S. aureus infections, their disease causing mechanisms need to be better understood. One of the many virulence factors of S. aureus to cause disease are superoxide dismutases (SODs). In S. aureus there are two superoxide dismutases, SodA and SodM. The loss of both SODs during a retro-orbital mouse infection led to a decrease in the ability of S. aureus to cause disease [65]. However, the individual contributions of SodA and SodM to the pathogenesis of S. aureus are not completely understood. In this work I aimed to identify how SodA and SodM provide protection to S. aureus and contribute to combating nutritional immunity.","abstract_has_math":false,"creators":["Garcia, Yuritzi M."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Microbiology","degree_department":null,"school":null,"contributors":["Kehl-Fie, Thomas E.","Imlay, James","Kuzminov, Andrei","Slauch, James"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-08-23T20:44:38Z","date_published":"2019-08-23T20:44:38Z","updated_at":"2026-07-22T22:24:44Z","subjects":["Staphylococcus aureus","superoxide dismutase","metals"],"languages":["en"],"rights":["Copyright 2019 Yuritzi Garcia"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/105161","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kehl-Fie, Thomas E.","Imlay, James","Kuzminov, Andrei","Slauch, James"]},{"key":"dc:creator","label":"Author","values":["Garcia, Yuritzi M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-08-23T20:44:38Z","2021-08-24T09:15:31Z","2019-04-08","2019-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Microbiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Staphylococcus aureus","superoxide dismutase","metals"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2019 Yuritzi Garcia"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/105161"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bacterial infections are a leading cause of death worldwide. One disease-causing organism is Staphylococcus aureus. Despite numerous methods used by the host immune system to combat infection, S. aureus is still a major health risk. Recently, the Centers for Disease Control and Prevention and the World Health Organization listed S. aureus as one of the top threats to human health [15, 88]. The elevated threat is due to an increase of antibiotic resistant isolates and continued prevalence in the general community [15, 88], which calls for the development of new therapeutic targets to treat staphylococcal infections. In order to combat S. aureus infections, their disease causing mechanisms need to be better understood. One of the many virulence factors of S. aureus to cause disease are superoxide dismutases (SODs). In S. aureus there are two superoxide dismutases, SodA and SodM. The loss of both SODs during a retro-orbital mouse infection led to a decrease in the ability of S. aureus to cause disease [65]. However, the individual contributions of SodA and SodM to the pathogenesis of S. aureus are not completely understood. In this work I aimed to identify how SodA and SodM provide protection to S. aureus and contribute to combating nutritional immunity.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01","The student, Yuritzi Garcia, accepted the attached license on 2019-04-05 at 13:58.","The student, Yuritzi Garcia, submitted this Dissertation for approval on 2019-04-05 at 14:02.","This Dissertation was approved for publication on 2019-04-08 at 09:45.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13497 on 2019-08-22 at 16:20:44","Made available in DSpace on 2019-08-23T20:44:38Z (GMT). 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One disease-causing organism is Staphylococcus aureus. Despite numerous methods used by the host immune system to combat infection, S. aureus is still a major health risk. Recently, the Centers for Disease Control and Prevention and the World Health Organization listed S. aureus as one of the top threats to human health [15, 88]. The elevated threat is due to an increase of antibiotic resistant isolates and continued prevalence in the general community [15, 88], which calls for the development of new therapeutic targets to treat staphylococcal infections. In order to combat S. aureus infections, their disease causing mechanisms need to be better understood. One of the many virulence factors of S. aureus to cause disease are superoxide dismutases (SODs). In S. aureus there are two superoxide dismutases, SodA and SodM. The loss of both SODs during a retro-orbital mouse infection led to a decrease in the ability of S. aureus to cause disease [65]. However, the individual contributions of SodA and SodM to the pathogenesis of S. aureus are not completely understood. In this work I aimed to identify how SodA and SodM provide protection to S. aureus and contribute to combating nutritional immunity.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01","The student, Yuritzi Garcia, accepted the attached license on 2019-04-05 at 13:58.","The student, Yuritzi Garcia, submitted this Dissertation for approval on 2019-04-05 at 14:02.","This Dissertation was approved for publication on 2019-04-08 at 09:45.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13497 on 2019-08-22 at 16:20:44","Made available in DSpace on 2019-08-23T20:44:38Z (GMT). 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