{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/105080"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/105080","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Epigenetic mechanisms of resilience to psychopathology following trauma exposure","abstract":"There is a dearth of research examining epigenetic modifications associated with resilience to psychopathology after trauma exposure. This study sought to investigate resilience-associated methylation differences in 51 glucocorticoid receptor regulatory network (GRRN) genes which have been previously associated with various forms of psychopathology. Multiple linear regressions were performed on each of the CpG sites associated with the 51 GRRN genes with resiliency as the predictor and DNA methylation as the outcome in a sample of 171 Detroit residents age 20-89 (M = 54.00, SD =14.14, 63.2% female). Resilience was significantly (p < 0.05) associated with changes in methylation at 23 genes, with 6 surviving FDR correction. T-tests were then performed for the 23 CpG sites that met nominal significance to assess whether there was significant differential methylation in the resilient group relative to the non-resilient group. Nine CpG sites demonstrated significant resilience-associated methylation differences as well as differential methylation when compared to the susceptible group. The results of this study identify potential candidate genes associated with resiliency and contribute to the growing body of literature seeking to identify resiliency markers in humans.","abstract_html":"There is a dearth of research examining epigenetic modifications associated with resilience to psychopathology after trauma exposure. This study sought to investigate resilience-associated methylation differences in 51 glucocorticoid receptor regulatory network (GRRN) genes which have been previously associated with various forms of psychopathology. Multiple linear regressions were performed on each of the CpG sites associated with the 51 GRRN genes with resiliency as the predictor and DNA methylation as the outcome in a sample of 171 Detroit residents age 20-89 (M = 54.00, SD =14.14, 63.2% female). Resilience was significantly (p &lt; 0.05) associated with changes in methylation at 23 genes, with 6 surviving FDR correction. T-tests were then performed for the 23 CpG sites that met nominal significance to assess whether there was significant differential methylation in the resilient group relative to the non-resilient group. Nine CpG sites demonstrated significant resilience-associated methylation differences as well as differential methylation when compared to the susceptible group. The results of this study identify potential candidate genes associated with resiliency and contribute to the growing body of literature seeking to identify resiliency markers in humans.","abstract_has_math":false,"creators":["Bucknor, Brianna"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Hankin, Benjamin L."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-08-23T20:36:07Z","date_published":"2019-08-23T20:36:07Z","updated_at":"2026-07-22T22:24:44Z","subjects":["PTSD","trauma","resilience","psychopathology","epigenetics"],"languages":["en"],"rights":["Copyright 2019 Brianna Bucknor"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/105080","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hankin, Benjamin L."]},{"key":"dc:creator","label":"Author","values":["Bucknor, Brianna"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-08-23T20:36:07Z","2021-08-24T09:15:28Z","2019-04-24","2019-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["PTSD","trauma","resilience","psychopathology","epigenetics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2019 Brianna Bucknor"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/105080"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["There is a dearth of research examining epigenetic modifications associated with resilience to psychopathology after trauma exposure. This study sought to investigate resilience-associated methylation differences in 51 glucocorticoid receptor regulatory network (GRRN) genes which have been previously associated with various forms of psychopathology. Multiple linear regressions were performed on each of the CpG sites associated with the 51 GRRN genes with resiliency as the predictor and DNA methylation as the outcome in a sample of 171 Detroit residents age 20-89 (M = 54.00, SD =14.14, 63.2% female). Resilience was significantly (p < 0.05) associated with changes in methylation at 23 genes, with 6 surviving FDR correction. T-tests were then performed for the 23 CpG sites that met nominal significance to assess whether there was significant differential methylation in the resilient group relative to the non-resilient group. Nine CpG sites demonstrated significant resilience-associated methylation differences as well as differential methylation when compared to the susceptible group. The results of this study identify potential candidate genes associated with resiliency and contribute to the growing body of literature seeking to identify resiliency markers in humans.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-05-01","The student, Brianna Bucknor, accepted the attached license on 2019-04-23 at 19:41.","The student, Brianna Bucknor, submitted this Thesis for approval on 2019-04-23 at 20:13.","This Thesis was approved for publication on 2019-04-24 at 12:56.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13852 on 2019-08-22 at 15:07:57","Made available in DSpace on 2019-08-23T20:36:07Z (GMT). No. of bitstreams: 2 BUCKNOR-THESIS-2019.pdf: 441215 bytes, checksum: 40120387a2bcaac48431f77773cea530 (MD5) LICENSE.txt: 4212 bytes, checksum: a2fc42cc9241f76a582c59840752232e (MD5) Previous issue date: 2019-04-24","Embargo set by: Seth Robbins for item 112199 Lift date: 2021-08-23T20:36:18Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only Restriction Lifted for Item 112199 on 2021-08-24T09:15:28Z."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Epigenetic mechanisms of resilience to psychopathology following trauma exposure"]}]}],"canonical_facts":{"dc:contributor":["Hankin, Benjamin L."],"dc:creator":["Bucknor, Brianna"],"dc:date":["2019-08-23T20:36:07Z","2021-08-24T09:15:28Z","2019-04-24","2019-05"],"dc:description":["There is a dearth of research examining epigenetic modifications associated with resilience to psychopathology after trauma exposure. This study sought to investigate resilience-associated methylation differences in 51 glucocorticoid receptor regulatory network (GRRN) genes which have been previously associated with various forms of psychopathology. Multiple linear regressions were performed on each of the CpG sites associated with the 51 GRRN genes with resiliency as the predictor and DNA methylation as the outcome in a sample of 171 Detroit residents age 20-89 (M = 54.00, SD =14.14, 63.2% female). Resilience was significantly (p < 0.05) associated with changes in methylation at 23 genes, with 6 surviving FDR correction. T-tests were then performed for the 23 CpG sites that met nominal significance to assess whether there was significant differential methylation in the resilient group relative to the non-resilient group. Nine CpG sites demonstrated significant resilience-associated methylation differences as well as differential methylation when compared to the susceptible group. The results of this study identify potential candidate genes associated with resiliency and contribute to the growing body of literature seeking to identify resiliency markers in humans.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-05-01","The student, Brianna Bucknor, accepted the attached license on 2019-04-23 at 19:41.","The student, Brianna Bucknor, submitted this Thesis for approval on 2019-04-23 at 20:13.","This Thesis was approved for publication on 2019-04-24 at 12:56.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13852 on 2019-08-22 at 15:07:57","Made available in DSpace on 2019-08-23T20:36:07Z (GMT). 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