{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/102956"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/102956","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Fabrication and testing of silicon integrated nanofluidic channels for neurochemical transport","abstract":"Several neurosensing techniques have been developed to study neurological activity in mammalian brains, though none of these methods fully satisfy the requirements for high-resolution neurochemical sensing. Therefore, to fulfill this need, we have developed a process to build a monolithic neurochemical sampling probe in which the size and spatial resolution can be directly controlled. Moreover, we have developed test benches to characterize the fluidic and chemical transport properties of the device, which is directly related to the temporal resolution. However, upon testing, we discovered that fluid flow is not possible through either of the two devices fabricated thus far, which is in disagreement with our flow simulation results. For the next step, we will build test structures to measure the performance of the nanofluidic channels without probe integration to determine the root cause of this issue. Upon resolving this issue, we will be able to measure the temporal resolution of various integrated probe designs to optimize the performance of our nanofluidic device.","abstract_html":"Several neurosensing techniques have been developed to study neurological activity in mammalian brains, though none of these methods fully satisfy the requirements for high-resolution neurochemical sensing. Therefore, to fulfill this need, we have developed a process to build a monolithic neurochemical sampling probe in which the size and spatial resolution can be directly controlled. Moreover, we have developed test benches to characterize the fluidic and chemical transport properties of the device, which is directly related to the temporal resolution. However, upon testing, we discovered that fluid flow is not possible through either of the two devices fabricated thus far, which is in disagreement with our flow simulation results. For the next step, we will build test structures to measure the performance of the nanofluidic channels without probe integration to determine the root cause of this issue. Upon resolving this issue, we will be able to measure the temporal resolution of various integrated probe designs to optimize the performance of our nanofluidic device.","abstract_has_math":false,"creators":["Esters, Ari"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Vlasov, Yurii"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-02-08T18:44:43Z","date_published":"2019-02-08T18:44:43Z","updated_at":"2026-07-22T22:24:42Z","subjects":["Nanofluidics, nanotechnology, microfluidics, microtechnology, silicon, neurotechnology, brain chemistry, neuroscience"],"languages":["en"],"rights":["Copyright 2018 Ari Esters"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/102956","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Vlasov, Yurii"]},{"key":"dc:creator","label":"Author","values":["Esters, Ari"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-02-08T18:44:43Z","2021-02-09T10:15:30Z","2018-12-11","2018-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Nanofluidics, nanotechnology, microfluidics, microtechnology, silicon, neurotechnology, brain chemistry, neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2018 Ari Esters"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/102956"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Several neurosensing techniques have been developed to study neurological activity in mammalian brains, though none of these methods fully satisfy the requirements for high-resolution neurochemical sensing. Therefore, to fulfill this need, we have developed a process to build a monolithic neurochemical sampling probe in which the size and spatial resolution can be directly controlled. Moreover, we have developed test benches to characterize the fluidic and chemical transport properties of the device, which is directly related to the temporal resolution. However, upon testing, we discovered that fluid flow is not possible through either of the two devices fabricated thus far, which is in disagreement with our flow simulation results. For the next step, we will build test structures to measure the performance of the nanofluidic channels without probe integration to determine the root cause of this issue. Upon resolving this issue, we will be able to measure the temporal resolution of various integrated probe designs to optimize the performance of our nanofluidic device.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01","The student, Ari Esters, accepted the attached license on 2018-12-10 at 18:59.","The student, Ari Esters, submitted this Thesis for approval on 2018-12-10 at 19:01.","This Thesis was approved for publication on 2018-12-11 at 07:58.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13279 on 2019-02-08 at 11:41:48","Made available in DSpace on 2019-02-08T18:44:43Z (GMT). No. of bitstreams: 2 ESTERS-THESIS-2018.pdf: 4342023 bytes, checksum: 7a8182a9ef52e1134f57a8474735d315 (MD5) LICENSE.txt: 4224 bytes, checksum: b2460f67be06a0a79728b58fe2c3e1fe (MD5) Previous issue date: 2018-12-11","Embargo set by: Seth Robbins for item 109984 Lift date: 2021-02-08T18:44:50Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 109984 on 2021-02-09T10:15:30Z."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Fabrication and testing of silicon integrated nanofluidic channels for neurochemical transport"]}]}],"canonical_facts":{"dc:contributor":["Vlasov, Yurii"],"dc:creator":["Esters, Ari"],"dc:date":["2019-02-08T18:44:43Z","2021-02-09T10:15:30Z","2018-12-11","2018-12"],"dc:description":["Several neurosensing techniques have been developed to study neurological activity in mammalian brains, though none of these methods fully satisfy the requirements for high-resolution neurochemical sensing. Therefore, to fulfill this need, we have developed a process to build a monolithic neurochemical sampling probe in which the size and spatial resolution can be directly controlled. Moreover, we have developed test benches to characterize the fluidic and chemical transport properties of the device, which is directly related to the temporal resolution. However, upon testing, we discovered that fluid flow is not possible through either of the two devices fabricated thus far, which is in disagreement with our flow simulation results. For the next step, we will build test structures to measure the performance of the nanofluidic channels without probe integration to determine the root cause of this issue. Upon resolving this issue, we will be able to measure the temporal resolution of various integrated probe designs to optimize the performance of our nanofluidic device.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01","The student, Ari Esters, accepted the attached license on 2018-12-10 at 18:59.","The student, Ari Esters, submitted this Thesis for approval on 2018-12-10 at 19:01.","This Thesis was approved for publication on 2018-12-11 at 07:58.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13279 on 2019-02-08 at 11:41:48","Made available in DSpace on 2019-02-08T18:44:43Z (GMT). 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