{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/102854"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/102854","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Effects of swelling on brain tissue mechanical properties by indentation","abstract":"Constructing more in-depth models of the brain’s behavior has gained significant attention in recent years, particularly for the goal of modeling brain injury and function. Mechanical studies have improved in effectiveness with the development of more standard testing protocols and the contribution of mechanistic models to understanding the brain’s behavior. Due to the complexity of the brain’s structure and pathophysiology of diseases and conditions related to swelling, studies have mainly focused on identifying the mechanisms underlying brain tissue swelling. Most commonly, magnetic resonance imaging techniques have been used, particularly with the development of magnetic resonance elastography, to study swelling in vivo. However, localized testing on in vitro tissue slices have become useful alternatives as models of study with atomic force microscopy and nanoindentation. Here, the method of nanoindentation is applied to brain tissue slices to identify the effects of swelling on the tissue’s mechanical properties. The stiffness and relaxation properties of brain tissue slices are identified, suggesting a useful and simple alternative to in vivo imaging for identifying the effects of diseases such as edema or hydrocephalus on the brain.","abstract_html":"Constructing more in-depth models of the brain’s behavior has gained significant attention in recent years, particularly for the goal of modeling brain injury and function. Mechanical studies have improved in effectiveness with the development of more standard testing protocols and the contribution of mechanistic models to understanding the brain’s behavior. Due to the complexity of the brain’s structure and pathophysiology of diseases and conditions related to swelling, studies have mainly focused on identifying the mechanisms underlying brain tissue swelling. Most commonly, magnetic resonance imaging techniques have been used, particularly with the development of magnetic resonance elastography, to study swelling in vivo. However, localized testing on in vitro tissue slices have become useful alternatives as models of study with atomic force microscopy and nanoindentation. Here, the method of nanoindentation is applied to brain tissue slices to identify the effects of swelling on the tissue’s mechanical properties. The stiffness and relaxation properties of brain tissue slices are identified, suggesting a useful and simple alternative to in vivo imaging for identifying the effects of diseases such as edema or hydrocephalus on the brain.","abstract_has_math":false,"creators":["Shyu, Peter"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":["Hu, Yuhang"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-02-07T20:44:28Z","date_published":"2019-02-07T20:44:28Z","updated_at":"2026-07-22T22:24:42Z","subjects":["brain tissue, swelling, indentation"],"languages":["en"],"rights":["Copyright 2018 Peter Shyu"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/102854","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hu, Yuhang"]},{"key":"dc:creator","label":"Author","values":["Shyu, Peter"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-02-07T20:44:28Z","2021-02-08T10:15:25Z","2018-12-12","2018-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["brain tissue, swelling, indentation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2018 Peter Shyu"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/102854"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Constructing more in-depth models of the brain’s behavior has gained significant attention in recent years, particularly for the goal of modeling brain injury and function. Mechanical studies have improved in effectiveness with the development of more standard testing protocols and the contribution of mechanistic models to understanding the brain’s behavior. Due to the complexity of the brain’s structure and pathophysiology of diseases and conditions related to swelling, studies have mainly focused on identifying the mechanisms underlying brain tissue swelling. Most commonly, magnetic resonance imaging techniques have been used, particularly with the development of magnetic resonance elastography, to study swelling in vivo. However, localized testing on in vitro tissue slices have become useful alternatives as models of study with atomic force microscopy and nanoindentation. Here, the method of nanoindentation is applied to brain tissue slices to identify the effects of swelling on the tissue’s mechanical properties. The stiffness and relaxation properties of brain tissue slices are identified, suggesting a useful and simple alternative to in vivo imaging for identifying the effects of diseases such as edema or hydrocephalus on the brain.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-12-01","The student, Peter Shyu, accepted the attached license on 2018-12-10 at 17:24.","The student, Peter Shyu, submitted this Thesis for approval on 2018-12-10 at 17:30.","This Thesis was approved for publication on 2018-12-12 at 11:10.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13277 on 2019-02-07 at 14:23:22","Made available in DSpace on 2019-02-07T20:44:28Z (GMT). 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Mechanical studies have improved in effectiveness with the development of more standard testing protocols and the contribution of mechanistic models to understanding the brain’s behavior. Due to the complexity of the brain’s structure and pathophysiology of diseases and conditions related to swelling, studies have mainly focused on identifying the mechanisms underlying brain tissue swelling. Most commonly, magnetic resonance imaging techniques have been used, particularly with the development of magnetic resonance elastography, to study swelling in vivo. However, localized testing on in vitro tissue slices have become useful alternatives as models of study with atomic force microscopy and nanoindentation. Here, the method of nanoindentation is applied to brain tissue slices to identify the effects of swelling on the tissue’s mechanical properties. The stiffness and relaxation properties of brain tissue slices are identified, suggesting a useful and simple alternative to in vivo imaging for identifying the effects of diseases such as edema or hydrocephalus on the brain.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-12-01","The student, Peter Shyu, accepted the attached license on 2018-12-10 at 17:24.","The student, Peter Shyu, submitted this Thesis for approval on 2018-12-10 at 17:30.","This Thesis was approved for publication on 2018-12-12 at 11:10.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13277 on 2019-02-07 at 14:23:22","Made available in DSpace on 2019-02-07T20:44:28Z (GMT). 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