{"id":{"repo_id":"uic","oai_identifier":"oai:figshare.com:article/30426520"},"canonical_url":"https://search.dev.ndltd.org/etd/uic/oai:figshare.com:article/30426520","repository":{"repo_id":"uic","name":"University of Illinois - Chicago","base_url":"https://api.figshare.com/v2/oai"},"display":{"title":"CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis","abstract":"In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model.","abstract_html":"In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model.","abstract_has_math":false,"creators":["Leslie Carrillo-Saenz (22483978)"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-08-01T00:00:00Z","date_published":"2025-08-01T00:00:00Z","updated_at":"2026-07-27T21:35:00Z","subjects":["Biology","Neuroscience"],"languages":[],"rights":["In Copyright","Open Access after 2027-09-01"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.25417/uic.30426520.v1","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Leslie Carrillo-Saenz (22483978)"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-08-01T00:00:00Z"]},{"key":"dc:relation","label":"Dc Relation","values":["https://figshare.com/articles/thesis/CX3CR1_Neuroimmune_Microglial_Cell_Forkhead_Box_Class_O1_FoxO1_Contributions_to_Metabolic_Homeostasis/30426520"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology","Neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright","Open Access after 2027-09-01"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25417/uic.30426520.v1"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model."]},{"key":"dc:title","label":"Title","values":["CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis"]}]}],"canonical_facts":{"dc:creator":["Leslie Carrillo-Saenz (22483978)"],"dc:date":["2025-08-01T00:00:00Z"],"dc:description":["In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model."],"dc:identifier":["10.25417/uic.30426520.v1"],"dc:relation":["https://figshare.com/articles/thesis/CX3CR1_Neuroimmune_Microglial_Cell_Forkhead_Box_Class_O1_FoxO1_Contributions_to_Metabolic_Homeostasis/30426520"],"dc:rights":["In Copyright","Open Access after 2027-09-01"],"dc:subject":["Biology","Neuroscience"],"dc:title":["CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T21:35:00Z"}