{"id":{"repo_id":"uic","oai_identifier":"oai:figshare.com:article/30426328"},"canonical_url":"https://search.dev.ndltd.org/etd/uic/oai:figshare.com:article/30426328","repository":{"repo_id":"uic","name":"University of Illinois - Chicago","base_url":"https://api.figshare.com/v2/oai"},"display":{"title":"Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery","abstract":"This dissertation focuses on the new materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the DSPE-RxHyC, and the cationic ionizable peptide RxHyC polysaccharide sugar mannan conjugates, the RxHyC-mannan. Such three different conjugates focus on different functionalities, with predesigned peptide sequences and the backbone to achieve desired results for siRNA delivery.","abstract_html":"This dissertation focuses on the new materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the DSPE-RxHyC, and the cationic ionizable peptide RxHyC polysaccharide sugar mannan conjugates, the RxHyC-mannan. Such three different conjugates focus on different functionalities, with predesigned peptide sequences and the backbone to achieve desired results for siRNA delivery.","abstract_has_math":false,"creators":["Yiqing Yang (775314)"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-08-01T00:00:00Z","date_published":"2025-08-01T00:00:00Z","updated_at":"2026-07-27T21:34:56Z","subjects":["Gene delivery"],"languages":[],"rights":["In Copyright","Open Access after 2027-09-01"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.25417/uic.30426328.v1","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Yiqing Yang (775314)"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-08-01T00:00:00Z"]},{"key":"dc:relation","label":"Dc Relation","values":["https://figshare.com/articles/thesis/Conjugation_of_Zwitterionic_and_Cationic_Peptides_to_Lipid_and_Polymer_for_Gene_Delivery/30426328"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Gene delivery"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright","Open Access after 2027-09-01"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25417/uic.30426328.v1"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This dissertation focuses on the new materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the DSPE-RxHyC, and the cationic ionizable peptide RxHyC polysaccharide sugar mannan conjugates, the RxHyC-mannan. Such three different conjugates focus on different functionalities, with predesigned peptide sequences and the backbone to achieve desired results for siRNA delivery."]},{"key":"dc:title","label":"Title","values":["Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery"]}]}],"canonical_facts":{"dc:creator":["Yiqing Yang (775314)"],"dc:date":["2025-08-01T00:00:00Z"],"dc:description":["This dissertation focuses on the new materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the DSPE-RxHyC, and the cationic ionizable peptide RxHyC polysaccharide sugar mannan conjugates, the RxHyC-mannan. Such three different conjugates focus on different functionalities, with predesigned peptide sequences and the backbone to achieve desired results for siRNA delivery."],"dc:identifier":["10.25417/uic.30426328.v1"],"dc:relation":["https://figshare.com/articles/thesis/Conjugation_of_Zwitterionic_and_Cationic_Peptides_to_Lipid_and_Polymer_for_Gene_Delivery/30426328"],"dc:rights":["In Copyright","Open Access after 2027-09-01"],"dc:subject":["Gene delivery"],"dc:title":["Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T21:34:56Z"}