{"id":{"repo_id":"ubc","oai_identifier":"oai:circle.library.ubc.ca:2429/1446"},"canonical_url":"https://search.dev.ndltd.org/etd/ubc/oai:circle.library.ubc.ca:2429/1446","repository":{"repo_id":"ubc","name":"University of British Columbia","base_url":"http://circle.library.ubc.ca/oai/request"},"display":{"title":"Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens","abstract":"Anatomical studies have identified major efferent pathways from the hippocampus to the nucleus accumbens (N.Acc.), but the functional significance of this interaction remains unclear. The delayed spatial win-shift radial arm maze task has been used as a selective behavioral measure of damage to the hippocampal system, whereas the cued win-stay version of this task is unaffected by hippocampal lesions, but is disrupted by lesions in the dorsal striatum. The present study utilized these two procedures, along with reversible lidocaine-induced lesions of the N.Acc., to determine whether the N.Acc. is part of the extra-hippocampal system that subserves efficient memory-based foraging behavior. These lesions impaired performance on the spatial win-shift but not the cued win-stay task. Pre-training lesions on the spatial win-shift task did not affect foraging for four pellets during either the training or test phases of the experiment. In contrast, lidocaine-induced lesions, given prior to the test-phase, significantly disrupted retrieval of four pellets on the 8-arm maze. Comparable deficits also were observed in animals trained to forage efficiently for four pellets on an 8-arm maze, without prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine-infusions into the N.Acc. on spatial win-shift performance in animals receiving this treatment prior to both training and test phases. Collectively, these results indicate that the N.Acc. interacts with the hippocampus in guiding spatial win-shift behavior by allowing information about previously visited spatial locations to influence foraging in a complex radial arm maze environment.","abstract_html":"Anatomical studies have identified major efferent pathways from the hippocampus to the nucleus accumbens (N.Acc.), but the functional significance of this interaction remains unclear. The delayed spatial win-shift radial arm maze task has been used as a selective behavioral measure of damage to the hippocampal system, whereas the cued win-stay version of this task is unaffected by hippocampal lesions, but is disrupted by lesions in the dorsal striatum. The present study utilized these two procedures, along with reversible lidocaine-induced lesions of the N.Acc., to determine whether the N.Acc. is part of the extra-hippocampal system that subserves efficient memory-based foraging behavior. These lesions impaired performance on the spatial win-shift but not the cued win-stay task. Pre-training lesions on the spatial win-shift task did not affect foraging for four pellets during either the training or test phases of the experiment. In contrast, lidocaine-induced lesions, given prior to the test-phase, significantly disrupted retrieval of four pellets on the 8-arm maze. Comparable deficits also were observed in animals trained to forage efficiently for four pellets on an 8-arm maze, without prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine-infusions into the N.Acc. on spatial win-shift performance in animals receiving this treatment prior to both training and test phases. Collectively, these results indicate that the N.Acc. interacts with the hippocampus in guiding spatial win-shift behavior by allowing information about previously visited spatial locations to influence foraging in a complex radial arm maze environment.","abstract_has_math":false,"creators":["Seamans, Jeremy Keith"],"institution":"University of British Columbia","degree_name":"Master of Arts - MA","degree_level":"master's","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1993,"date_issued":"1993","date_published":"1993","updated_at":"2026-07-24T05:07:26Z","subjects":[],"languages":["eng"],"rights":["For non-commercial purposes only, such as research, private study and education. 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The present study utilized these two procedures, along with reversible lidocaine-induced lesions of the N.Acc., to determine whether the N.Acc. is part of the extra-hippocampal system that subserves efficient memory-based foraging behavior. These lesions impaired performance on the spatial win-shift but not the cued win-stay task. Pre-training lesions on the spatial win-shift task did not affect foraging for four pellets during either the training or test phases of the experiment. In contrast, lidocaine-induced lesions, given prior to the test-phase, significantly disrupted retrieval of four pellets on the 8-arm maze. Comparable deficits also were observed in animals trained to forage efficiently for four pellets on an 8-arm maze, without prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine-infusions into the N.Acc. on spatial win-shift performance in animals receiving this treatment prior to both training and test phases. Collectively, these results indicate that the N.Acc. interacts with the hippocampus in guiding spatial win-shift behavior by allowing information about previously visited spatial locations to influence foraging in a complex radial arm maze environment."]},{"key":"dc:format","label":"Dc Format","values":["3443278","application/pdf"]},{"key":"dc:title","label":"Title","values":["Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens"]}]}],"canonical_facts":{"dc:creator":["Seamans, Jeremy Keith"],"dc:date":["1993"],"dc:description":["Anatomical studies have identified major efferent pathways from the hippocampus to the nucleus accumbens (N.Acc.), but the functional significance of this interaction remains unclear. The delayed spatial win-shift radial arm maze task has been used as a selective behavioral measure of damage to the hippocampal system, whereas the cued win-stay version of this task is unaffected by hippocampal lesions, but is disrupted by lesions in the dorsal striatum. The present study utilized these two procedures, along with reversible lidocaine-induced lesions of the N.Acc., to determine whether the N.Acc. is part of the extra-hippocampal system that subserves efficient memory-based foraging behavior. These lesions impaired performance on the spatial win-shift but not the cued win-stay task. Pre-training lesions on the spatial win-shift task did not affect foraging for four pellets during either the training or test phases of the experiment. In contrast, lidocaine-induced lesions, given prior to the test-phase, significantly disrupted retrieval of four pellets on the 8-arm maze. Comparable deficits also were observed in animals trained to forage efficiently for four pellets on an 8-arm maze, without prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine-infusions into the N.Acc. on spatial win-shift performance in animals receiving this treatment prior to both training and test phases. Collectively, these results indicate that the N.Acc. interacts with the hippocampus in guiding spatial win-shift behavior by allowing information about previously visited spatial locations to influence foraging in a complex radial arm maze environment."],"dc:format":["3443278","application/pdf"],"dc:identifier":["http://hdl.handle.net/2429/1446","http://circle.library.ubc.ca/bitstream/2429/1446/1/ubc_1993_fall_seamans_jeremy.pdf"],"dc:language":["eng"],"dc:publisher":["University of British Columbia"],"dc:rights":["For non-commercial purposes only, such as research, private study and education. 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