{"id":{"repo_id":"uab","oai_identifier":"oai:digitalcommons.library.uab.edu:etd-collection-8094"},"canonical_url":"https://search.dev.ndltd.org/etd/uab/oai:digitalcommons.library.uab.edu:etd-collection-8094","repository":{"repo_id":"uab","name":"University of Alabama Birmingham","base_url":"https://digitalcommons.library.uab.edu/do/oai/"},"display":{"title":"Synthesis and Characterization of 1-Methyl-4-Substituted-3-Piperidine-Carboxylic Acid N, N-Diethyamide.","abstract":"Following the suggestion by Smythies that the major hallucinogens, mescaline, N,N-dimethyltryptamine (DMT) and d-lysergic acid diethylamide (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, 6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC), a compound similar in structure to the D-ring of LSD (Figure 1), blocked the behavioral disruption in rats induced by LSD as measured by Bovet-Gatti profiles on a Sidman avoidance schedule. Further studies by Christian et al. firmly established that THPC acts as a LSD antagonist since binding of LSD to a high affinity site on thesynaptosomal membrane is completely blocked by THPC. Dyer et al. showed that contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and LSD are blocked by THPC acting as a serotonin receptor antagonist. This study also demonstrated that although THPC acts as a hallucinogen antagonist, it is not as potent as other known antagonists such as 2-bromolysergic acid die-thylamide or cinanserin (N-[2-(3-N,N-dimethylaminopropylthio)-phenyl) cinnamide). ","abstract_html":"Following the suggestion by Smythies that the major hallucinogens, mescaline, N,N-dimethyltryptamine (DMT) and d-lysergic acid diethylamide (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, 6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC), a compound similar in structure to the D-ring of LSD (Figure 1), blocked the behavioral disruption in rats induced by LSD as measured by Bovet-Gatti profiles on a Sidman avoidance schedule. Further studies by Christian et al. firmly established that THPC acts as a LSD antagonist since binding of LSD to a high affinity site on thesynaptosomal membrane is completely blocked by THPC. Dyer et al. showed that contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and LSD are blocked by THPC acting as a serotonin receptor antagonist. This study also demonstrated that although THPC acts as a hallucinogen antagonist, it is not as potent as other known antagonists such as 2-bromolysergic acid die-thylamide or cinanserin (N-[2-(3-N,N-dimethylaminopropylthio)-phenyl) cinnamide). ","abstract_has_math":false,"creators":["Panu, Al Mukendi"],"institution":null,"degree_name":null,"degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1980,"date_issued":"1980-01-01T08:00:00Z","date_published":"1980-01-01T08:00:00Z","updated_at":"2026-07-24T05:06:15Z","subjects":["Mescaline","Sidman avoidance","Smythies","Behavioral disruption","Ballucinogen antagonist"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.library.uab.edu/etd-collection/7102","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Panu, Al Mukendi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mescaline","Sidman avoidance","Smythies","Behavioral disruption","Ballucinogen antagonist"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.library.uab.edu/etd-collection/7102"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Following the suggestion by Smythies that the major hallucinogens, mescaline, N,N-dimethyltryptamine (DMT) and d-lysergic acid diethylamide (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, 6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC), a compound similar in structure to the D-ring of LSD (Figure 1), blocked the behavioral disruption in rats induced by LSD as measured by Bovet-Gatti profiles on a Sidman avoidance schedule. Further studies by Christian et al. firmly established that THPC acts as a LSD antagonist since binding of LSD to a high affinity site on thesynaptosomal membrane is completely blocked by THPC. Dyer et al. showed that contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and LSD are blocked by THPC acting as a serotonin receptor antagonist. This study also demonstrated that although THPC acts as a hallucinogen antagonist, it is not as potent as other known antagonists such as 2-bromolysergic acid die-thylamide or cinanserin (N-[2-(3-N,N-dimethylaminopropylthio)-phenyl) cinnamide). "]},{"key":"dc:title","label":"Title","values":["Synthesis and Characterization of 1-Methyl-4-Substituted-3-Piperidine-Carboxylic Acid N, N-Diethyamide."]}]}],"canonical_facts":{"dc:creator":["Panu, Al Mukendi"],"dc:description.abstract":["Following the suggestion by Smythies that the major hallucinogens, mescaline, N,N-dimethyltryptamine (DMT) and d-lysergic acid diethylamide (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, 6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC), a compound similar in structure to the D-ring of LSD (Figure 1), blocked the behavioral disruption in rats induced by LSD as measured by Bovet-Gatti profiles on a Sidman avoidance schedule. Further studies by Christian et al. firmly established that THPC acts as a LSD antagonist since binding of LSD to a high affinity site on thesynaptosomal membrane is completely blocked by THPC. Dyer et al. showed that contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and LSD are blocked by THPC acting as a serotonin receptor antagonist. This study also demonstrated that although THPC acts as a hallucinogen antagonist, it is not as potent as other known antagonists such as 2-bromolysergic acid die-thylamide or cinanserin (N-[2-(3-N,N-dimethylaminopropylthio)-phenyl) cinnamide). "],"dc:identifier":["https://digitalcommons.library.uab.edu/etd-collection/7102"],"dc:subject":["Mescaline","Sidman avoidance","Smythies","Behavioral disruption","Ballucinogen antagonist"],"dc:title":["Synthesis and Characterization of 1-Methyl-4-Substituted-3-Piperidine-Carboxylic Acid N, N-Diethyamide."],"thesis:degree_level":["Thesis"]},"updated_at":"2026-07-24T05:06:15Z"}