{"id":{"repo_id":"uab","oai_identifier":"oai:digitalcommons.library.uab.edu:etd-collection-7970"},"canonical_url":"https://search.dev.ndltd.org/etd/uab/oai:digitalcommons.library.uab.edu:etd-collection-7970","repository":{"repo_id":"uab","name":"University of Alabama Birmingham","base_url":"https://digitalcommons.library.uab.edu/do/oai/"},"display":{"title":"Neuropsychological Functioning and Regional Cerebral Blood Flow: A Comparison Between Aged Normals and Alzheimer’s Type Dementia.","abstract":"The purpose of this study was to differentiate patients with Alzheimer’s disease from normal aged subjects using the Luria-Nebraska Neuropsychological Test Battery (Luria-Nebraska) and the 133 Xenon inhalation method of determining regional cerebral blood flow (rCBF). In addition, correlations between rCBF detectors and Luria-Nebraska localization scales were investigated in order to ascertain possible agreement on focal areas of functional brain tissue loss. Nine subjects with Alzheimer’s disease were compared to nine normal subjects who had been matched on the basis of age, sex, race, and education. Discriminant analysis revealed 100% correct classification of all patients and normals using three of the fourteen cognitive Luria-Nebraska scales. The pattern of cognitive scale scores of the Alzheimer’s subjects was examined and compared to that seen in the normal aged subjects. Analysis of variance revealed significant differences in rCBF with Alzheimer’s subjects showing lower rCBF than normals for rCBF parameters fi (p = .003), ISI (p = .005), and wj (p = .008) but not for Phi. Concordancebetween Luria-Nebraska localization scales and rCBF detectors showed the greatest agreement between the two variables in localizing brain dysfunction throughout the posterior left cerebral hemisphere.Results were discussed and directions for further research presented.","abstract_html":"The purpose of this study was to differentiate patients with Alzheimer’s disease from normal aged subjects using the Luria-Nebraska Neuropsychological Test Battery (Luria-Nebraska) and the 133 Xenon inhalation method of determining regional cerebral blood flow (rCBF). In addition, correlations between rCBF detectors and Luria-Nebraska localization scales were investigated in order to ascertain possible agreement on focal areas of functional brain tissue loss. Nine subjects with Alzheimer’s disease were compared to nine normal subjects who had been matched on the basis of age, sex, race, and education. Discriminant analysis revealed 100% correct classification of all patients and normals using three of the fourteen cognitive Luria-Nebraska scales. The pattern of cognitive scale scores of the Alzheimer’s subjects was examined and compared to that seen in the normal aged subjects. Analysis of variance revealed significant differences in rCBF with Alzheimer’s subjects showing lower rCBF than normals for rCBF parameters fi (p = .003), ISI (p = .005), and wj (p = .008) but not for Phi. Concordancebetween Luria-Nebraska localization scales and rCBF detectors showed the greatest agreement between the two variables in localizing brain dysfunction throughout the posterior left cerebral hemisphere.Results were discussed and directions for further research presented.","abstract_has_math":false,"creators":["Butler, Robert Walker"],"institution":null,"degree_name":null,"degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1981,"date_issued":"1981-01-01T08:00:00Z","date_published":"1981-01-01T08:00:00Z","updated_at":"2026-07-24T05:06:09Z","subjects":["Neuropsychological functioning","Alzheimer’s disease","Luria-Nebraska Neuropsychological Test Battery","Posterior left cerebral hemisphere"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.library.uab.edu/etd-collection/6978","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Butler, Robert Walker"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Neuropsychological functioning","Alzheimer’s disease","Luria-Nebraska Neuropsychological Test Battery","Posterior left cerebral hemisphere"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.library.uab.edu/etd-collection/6978"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The purpose of this study was to differentiate patients with Alzheimer’s disease from normal aged subjects using the Luria-Nebraska Neuropsychological Test Battery (Luria-Nebraska) and the 133 Xenon inhalation method of determining regional cerebral blood flow (rCBF). In addition, correlations between rCBF detectors and Luria-Nebraska localization scales were investigated in order to ascertain possible agreement on focal areas of functional brain tissue loss. Nine subjects with Alzheimer’s disease were compared to nine normal subjects who had been matched on the basis of age, sex, race, and education. Discriminant analysis revealed 100% correct classification of all patients and normals using three of the fourteen cognitive Luria-Nebraska scales. The pattern of cognitive scale scores of the Alzheimer’s subjects was examined and compared to that seen in the normal aged subjects. Analysis of variance revealed significant differences in rCBF with Alzheimer’s subjects showing lower rCBF than normals for rCBF parameters fi (p = .003), ISI (p = .005), and wj (p = .008) but not for Phi. Concordancebetween Luria-Nebraska localization scales and rCBF detectors showed the greatest agreement between the two variables in localizing brain dysfunction throughout the posterior left cerebral hemisphere.Results were discussed and directions for further research presented."]},{"key":"dc:title","label":"Title","values":["Neuropsychological Functioning and Regional Cerebral Blood Flow: A Comparison Between Aged Normals and Alzheimer’s Type Dementia."]}]}],"canonical_facts":{"dc:creator":["Butler, Robert Walker"],"dc:description.abstract":["The purpose of this study was to differentiate patients with Alzheimer’s disease from normal aged subjects using the Luria-Nebraska Neuropsychological Test Battery (Luria-Nebraska) and the 133 Xenon inhalation method of determining regional cerebral blood flow (rCBF). In addition, correlations between rCBF detectors and Luria-Nebraska localization scales were investigated in order to ascertain possible agreement on focal areas of functional brain tissue loss. Nine subjects with Alzheimer’s disease were compared to nine normal subjects who had been matched on the basis of age, sex, race, and education. Discriminant analysis revealed 100% correct classification of all patients and normals using three of the fourteen cognitive Luria-Nebraska scales. The pattern of cognitive scale scores of the Alzheimer’s subjects was examined and compared to that seen in the normal aged subjects. Analysis of variance revealed significant differences in rCBF with Alzheimer’s subjects showing lower rCBF than normals for rCBF parameters fi (p = .003), ISI (p = .005), and wj (p = .008) but not for Phi. Concordancebetween Luria-Nebraska localization scales and rCBF detectors showed the greatest agreement between the two variables in localizing brain dysfunction throughout the posterior left cerebral hemisphere.Results were discussed and directions for further research presented."],"dc:identifier":["https://digitalcommons.library.uab.edu/etd-collection/6978"],"dc:subject":["Neuropsychological functioning","Alzheimer’s disease","Luria-Nebraska Neuropsychological Test Battery","Posterior left cerebral hemisphere"],"dc:title":["Neuropsychological Functioning and Regional Cerebral Blood Flow: A Comparison Between Aged Normals and Alzheimer’s Type Dementia."],"thesis:degree_level":["Thesis"]},"updated_at":"2026-07-24T05:06:09Z"}