Phenylbutazone was first synthesized in 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.
Two other pharmaceutical agents of the pyrazole group are phenazone and amidopyrine; these were used as early as the nineteenth century. While phenazone and aminopyrine have basic properties, phenylbutazone exhibits distinctly acidic ones and is capable of forming salts with organic and inorganic bases.
In order to achieve a more basic understanding of how phenylbutazone produces effects, the following brief survey of the work that has been done with this compound is presented.
","abstract_html":"<p>Phenylbutazone was first synthesized in 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.</p><p>Two other pharmaceutical agents of the pyrazole group are phenazone and amidopyrine; these were used as early as the nineteenth century. While phenazone and aminopyrine have basic properties, phenylbutazone exhibits distinctly acidic ones and is capable of forming salts with organic and inorganic bases.</p><p>In order to achieve a more basic understanding of how phenylbutazone produces effects, the following brief survey of the work that has been done with this compound is presented.</p>","abstract_has_math":false,"creators":["Bauermeister, Ann Weyrauch"],"institution":null,"degree_name":"Master of Science (M.S.)","degree_level":"Thesis","degree_discipline":"Graduate School","degree_department":null,"school":null,"contributors":["Fuad Nahhas"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1972,"date_issued":"1972-01-01T08:00:00Z","date_published":"1972-01-01T08:00:00Z","updated_at":"2026-07-24T05:37:42Z","subjects":["Phenylbutazone","Fibroblasts","Life Sciences"],"languages":[],"rights":[],"rights_urls":["http://rightsstatements.org/vocab/NKC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://scholarlycommons.pacific.edu/uop_etds/1784","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Fuad Nahhas"]},{"key":"dc:creator","label":"Author","values":["Bauermeister, Ann Weyrauch"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-29T08:51:28Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Graduate School"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Phenylbutazone","Fibroblasts","Life Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["http://rightsstatements.org/vocab/NKC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarlycommons.pacific.edu/uop_etds/1784"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Phenylbutazone was first synthesized in 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.
Two other pharmaceutical agents of the pyrazole group are phenazone and amidopyrine; these were used as early as the nineteenth century. While phenazone and aminopyrine have basic properties, phenylbutazone exhibits distinctly acidic ones and is capable of forming salts with organic and inorganic bases.
In order to achieve a more basic understanding of how phenylbutazone produces effects, the following brief survey of the work that has been done with this compound is presented.
"]},{"key":"dc:source","label":"Dc Source","values":["65"]},{"key":"dc:title","label":"Title","values":["The effects of phenylbutazone on a strain of fibroblasts cultivated in vitro"]}]}],"canonical_facts":{"dc:contributor":["Fuad Nahhas"],"dc:creator":["Bauermeister, Ann Weyrauch"],"dc:date.available":["2018-06-29T08:51:28Z"],"dc:description.abstract":["Phenylbutazone was first synthesized in 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.
Two other pharmaceutical agents of the pyrazole group are phenazone and amidopyrine; these were used as early as the nineteenth century. While phenazone and aminopyrine have basic properties, phenylbutazone exhibits distinctly acidic ones and is capable of forming salts with organic and inorganic bases.
In order to achieve a more basic understanding of how phenylbutazone produces effects, the following brief survey of the work that has been done with this compound is presented.
"],"dc:identifier":["https://scholarlycommons.pacific.edu/uop_etds/1784"],"dc:rights":["http://rightsstatements.org/vocab/NKC/1.0/"],"dc:source":["65"],"dc:subject":["Phenylbutazone","Fibroblasts","Life Sciences"],"dc:title":["The effects of phenylbutazone on a strain of fibroblasts cultivated in vitro"],"thesis:degree_discipline":["Graduate School"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (M.S.)"]},"updated_at":"2026-07-24T05:37:42Z"}