An investigation of the release of 5-fluorouracil from ointment bases
During the several years in which this therapy has been developed and evaluated, as standard dermatological preparation has not been available. The objective of the present work was to study the release of 5-FU from various ointment bases and to attempt to determine the type of base which would release the compound most satisfactorily. The methods chosen were designed to determine the release and penetration of 5-FU both by in vitro and in vivo methods. A modified agar plate method was chosen as the in vitro test for measuring release and subsequent diffusion into the agar. The penetration of the compound from various bases was determined by applying the medicated bases to the skin of guinea pigs and subsequently analyzing a biopsy of the inuncted skin, using quantitative spectrophotometry.
Uracil, Fluorouracil, Fluoropyrimidines, Cancer chemotherapy, Antineoplastic agents, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences
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