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University of the Pacific

Chalcone derivatives from pyrrole-2-aldehyde

Abstract

dc:description.abstract

<p>Claisen first synthesized Chalcone in 1881 by condensing acetophenone with benzaldehyde using sodium methoxide as a condensing agent. Chalcone and its derivatives have been prepared primarily as intermediates for the synthesis of anthocyanins and other related pigments.</p><p>In recent years extensive preparation and study of chalcones has been carried out utilizing chalcones for their biological effects in medical and pharmaceutical fields. It has been shown that certain highly substituted compounds present in the flower pigments as additives to adhesive absorb ultraviolet radiation. Carboxylic acid chalcones have become known for their therapeutic action in the treatment of chronic kidney diseases, diseases of the eye, and rheumatoid diseases, such as bursitis and osteoarthritis. Treatment of chalcones with sulfuric acids to obtain α-ketosulfones, used as chemotherapeutic agents, has been under investigation and useful results have been obtained. Many of these α-ketosulfones are used to identify small amounts of sulfuric acid obtained from the cleavage and rearrangement of certain sulfones. In the research of genetic factors which regulate the formation of flavonoids factors in organisms, a suitable method for determining these compounds in small amounts in plant tissues is of very great importance and chalcones have been under investigation to serve this purpose. The observation of insecticidal bacteriostatic and tuberculostatic activities in chalcones has led to extensive investigation of chalcones.</p>

Degree

thesis:*
Name thesis:degree_name
Master of Science (M.S.)
Level thesis:degree_level
Thesis
Discipline thesis:degree_discipline
Chemistry
Year dc:date.available
1964

Author and committee

dc:creator, dc:contributor.*
Author dc:creator
  • Hamidi, Ahmad
Contributors dc:contributor
  • Emerson G. Cobb

Subjects

dc:subject × 3

Rights

dc:rights

Identifiers

dc:identifier.*
Repository record dc:identifier
https://scholarlycommons.pacific.edu/uop_etds/1578
OAI identifier oai:identifier
oai:scholarlycommons.pacific.edu:uop_etds-2577

Chain of custody

source
Harvested from
University of the Pacific
Base URL
scholarlycommons.pacific.edu/do/oai/
Last updated
2026-07-24
Source record
OAI-PMH GetRecord
citation

Hamidi, Ahmad. Chalcone derivatives from pyrrole-2-aldehyde. Thesis thesis, 1964. https://scholarlycommons.pacific.edu/uop_etds/1578