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University of the Pacific
Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase
Abstract
dc:description.abstract<p>Objectives: To date little is known of the interaction between diabetes and sex hormones in the vasculature. A number of studies suggest that premenopausal diabetic women loose their gender based cardiovascular protection. However, there is insufficient evidence to explain the mechanism underlying the loss of this gender based cardioprotection in premenopausal diabetic women. The objectives of this study were to investigate whether there is a gender difference in the aortic endothelial function in · streptozotocin (STZ, 58 mg/kg, iv)-induced diabetic rats, and the potential role of superoxide and cyclooxygenase (COX) metabolites in diabetes-induced vascular dysfunction.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science (M.S.)
- Level thesis:degree_level
- Thesis - Pacific Access Restricted
- Discipline thesis:degree_discipline
- Pharmaceutical and Chemical Sciences
- Year dc:date.available
- 2009
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Kekatpure, Avantika
- Contributors dc:contributor
-
- Roshanak Rahimian
Subjects
dc:subject × 8Rights
dc:rightsIdentifiers
dc:identifier.*- Repository record dc:identifier
- https://scholarlycommons.pacific.edu/uop_etds/737
- OAI identifier oai:identifier
- oai:scholarlycommons.pacific.edu:uop_etds-1736