Cancer is the second leading cause of death in the United States. The risk of cancer development and subsequent death from the disease increases sharply in the population over 55 years of age(1). Coagulation problems also increase with age and have been implicated in increasing the metastatic spread of cancer. Although cancer treatment has improved constantly it still remains quite toxic and improvement are needed
Mouse mammary tumor is a common form of cancer used for experimental animal study. This investigation was designed to study the nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulants. The main thrust of the research was in three areas: first, to develop a background in light microscope morphology of spontaneous mouse mammary tumor and its change with first and second passage into normal mice; second, to analyze change in leukocytic response in sham operated, tumor- and liver-implanted mice; and third, to analyze changes in leukocytic response to tumor implants with and without anticoagulation.
","abstract_html":"<p>Cancer is the second leading cause of death in the United States. The risk of cancer development and subsequent death from the disease increases sharply in the population over 55 years of age(1). Coagulation problems also increase with age and have been implicated in increasing the metastatic spread of cancer. Although cancer treatment has improved constantly it still remains quite toxic and improvement are needed</p><p>Mouse mammary tumor is a common form of cancer used for experimental animal study. This investigation was designed to study the nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulants. The main thrust of the research was in three areas: first, to develop a background in light microscope morphology of spontaneous mouse mammary tumor and its change with first and second passage into normal mice; second, to analyze change in leukocytic response in sham operated, tumor- and liver-implanted mice; and third, to analyze changes in leukocytic response to tumor implants with and without anticoagulation.</p>","abstract_has_math":false,"creators":["Liter, Melvin Earl"],"institution":null,"degree_name":"Master of Science (M.S.)","degree_level":"Thesis","degree_discipline":"Graduate Studies","degree_department":null,"school":null,"contributors":["Patrick N. Catania"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1984,"date_issued":"1984-01-01T08:00:00Z","date_published":"1984-01-01T08:00:00Z","updated_at":"2026-07-24T05:36:21Z","subjects":["Anticoagulants (Medicine)","Leucocytes","Tumor antigens","Medicine and Health Sciences"],"languages":[],"rights":[],"rights_urls":["http://rightsstatements.org/vocab/NKC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://scholarlycommons.pacific.edu/uop_etds/472","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Patrick N. Catania"]},{"key":"dc:creator","label":"Author","values":["Liter, Melvin Earl"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-29T09:08:24Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Graduate Studies"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Anticoagulants (Medicine)","Leucocytes","Tumor antigens","Medicine and Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["http://rightsstatements.org/vocab/NKC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarlycommons.pacific.edu/uop_etds/472"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Cancer is the second leading cause of death in the United States. The risk of cancer development and subsequent death from the disease increases sharply in the population over 55 years of age(1). Coagulation problems also increase with age and have been implicated in increasing the metastatic spread of cancer. Although cancer treatment has improved constantly it still remains quite toxic and improvement are needed
Mouse mammary tumor is a common form of cancer used for experimental animal study. This investigation was designed to study the nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulants. The main thrust of the research was in three areas: first, to develop a background in light microscope morphology of spontaneous mouse mammary tumor and its change with first and second passage into normal mice; second, to analyze change in leukocytic response in sham operated, tumor- and liver-implanted mice; and third, to analyze changes in leukocytic response to tumor implants with and without anticoagulation.
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Mouse mammary tumor is a common form of cancer used for experimental animal study. This investigation was designed to study the nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulants. The main thrust of the research was in three areas: first, to develop a background in light microscope morphology of spontaneous mouse mammary tumor and its change with first and second passage into normal mice; second, to analyze change in leukocytic response in sham operated, tumor- and liver-implanted mice; and third, to analyze changes in leukocytic response to tumor implants with and without anticoagulation.
"],"dc:identifier":["https://scholarlycommons.pacific.edu/uop_etds/472"],"dc:rights":["http://rightsstatements.org/vocab/NKC/1.0/"],"dc:source":["76"],"dc:subject":["Anticoagulants (Medicine)","Leucocytes","Tumor antigens","Medicine and Health Sciences"],"dc:title":["The nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulation"],"thesis:degree_discipline":["Graduate Studies"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (M.S.)"]},"updated_at":"2026-07-24T05:36:21Z"}