From the standpoint of physiologists, emphasis has been placed on viewing the chemical nature of the membrane as an operational barrier to the free diffusion of ions. This tends to explain the fact that the ionic composition of the cytoplasm of the animal cell differs from its external fluid environment.
It is well know that where sodium is the principal cation of the extracellular fluid, potassium has such a role inside the cell. Since there appears to be differential distribution of these ions across the cell membrane, this infers a concentration gradient of these ions. This differential distribution is important for certain life processes, for example, the propagation of nervous impulses mainly is dependent on the changes in concentration of sodium and potassium ions on both sides of the axonal membrane. Much effort has been put into elucidating the mechanism which cells maintain and change such concentration gradients. The enzyme system investigated in this study, namely, the sodium-activated adenosine triphosphatase, might be involved in maintaining this ionic gradient.<\\p>","abstract_html":"<p>From the standpoint of physiologists, emphasis has been placed on viewing the chemical nature of the membrane as an operational barrier to the free diffusion of ions. This tends to explain the fact that the ionic composition of the cytoplasm of the animal cell differs from its external fluid environment.</p><p>It is well know that where sodium is the principal cation of the extracellular fluid, potassium has such a role inside the cell. Since there appears to be differential distribution of these ions across the cell membrane, this infers a concentration gradient of these ions. This differential distribution is important for certain life processes, for example, the propagation of nervous impulses mainly is dependent on the changes in concentration of sodium and potassium ions on both sides of the axonal membrane. Much effort has been put into elucidating the mechanism which cells maintain and change such concentration gradients. The enzyme system investigated in this study, namely, the sodium-activated adenosine triphosphatase, might be involved in maintaining this ionic gradient.<\\p>","abstract_has_math":false,"creators":["Toh, Lily"],"institution":null,"degree_name":"Master of Science (M.S.)","degree_level":"Thesis","degree_discipline":"Graduate Studies","degree_department":null,"school":null,"contributors":["Donald Y. Shirachi"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1975,"date_issued":"1975-01-01T08:00:00Z","date_published":"1975-01-01T08:00:00Z","updated_at":"2026-07-24T05:36:21Z","subjects":["Adenosine triphosphatase","Enzymes","Brain chemistry","Medicine and Health Sciences","Pharmacy and Pharmaceutical Sciences"],"languages":[],"rights":[],"rights_urls":["http://rightsstatements.org/vocab/NKC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://scholarlycommons.pacific.edu/uop_etds/433","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Donald Y. Shirachi"]},{"key":"dc:creator","label":"Author","values":["Toh, Lily"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-29T08:50:57Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Graduate Studies"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Adenosine triphosphatase","Enzymes","Brain chemistry","Medicine and Health Sciences","Pharmacy and Pharmaceutical Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["http://rightsstatements.org/vocab/NKC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarlycommons.pacific.edu/uop_etds/433"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["
From the standpoint of physiologists, emphasis has been placed on viewing the chemical nature of the membrane as an operational barrier to the free diffusion of ions. This tends to explain the fact that the ionic composition of the cytoplasm of the animal cell differs from its external fluid environment.
It is well know that where sodium is the principal cation of the extracellular fluid, potassium has such a role inside the cell. Since there appears to be differential distribution of these ions across the cell membrane, this infers a concentration gradient of these ions. This differential distribution is important for certain life processes, for example, the propagation of nervous impulses mainly is dependent on the changes in concentration of sodium and potassium ions on both sides of the axonal membrane. Much effort has been put into elucidating the mechanism which cells maintain and change such concentration gradients. The enzyme system investigated in this study, namely, the sodium-activated adenosine triphosphatase, might be involved in maintaining this ionic gradient.<\\p>"]},{"key":"dc:source","label":"Dc Source","values":["102"]},{"key":"dc:title","label":"Title","values":["Studies on the characterization of a soluble factor of a sodium-activated, magnesium-dependent adenosinetriphosphatase in rat cerebral cortex"]}]}],"canonical_facts":{"dc:contributor":["Donald Y. Shirachi"],"dc:creator":["Toh, Lily"],"dc:date.available":["2018-06-29T08:50:57Z"],"dc:description.abstract":["
From the standpoint of physiologists, emphasis has been placed on viewing the chemical nature of the membrane as an operational barrier to the free diffusion of ions. This tends to explain the fact that the ionic composition of the cytoplasm of the animal cell differs from its external fluid environment.
It is well know that where sodium is the principal cation of the extracellular fluid, potassium has such a role inside the cell. Since there appears to be differential distribution of these ions across the cell membrane, this infers a concentration gradient of these ions. This differential distribution is important for certain life processes, for example, the propagation of nervous impulses mainly is dependent on the changes in concentration of sodium and potassium ions on both sides of the axonal membrane. Much effort has been put into elucidating the mechanism which cells maintain and change such concentration gradients. The enzyme system investigated in this study, namely, the sodium-activated adenosine triphosphatase, might be involved in maintaining this ionic gradient.<\\p>"],"dc:identifier":["https://scholarlycommons.pacific.edu/uop_etds/433"],"dc:rights":["http://rightsstatements.org/vocab/NKC/1.0/"],"dc:source":["102"],"dc:subject":["Adenosine triphosphatase","Enzymes","Brain chemistry","Medicine and Health Sciences","Pharmacy and Pharmaceutical Sciences"],"dc:title":["Studies on the characterization of a soluble factor of a sodium-activated, magnesium-dependent adenosinetriphosphatase in rat cerebral cortex"],"thesis:degree_discipline":["Graduate Studies"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (M.S.)"]},"updated_at":"2026-07-24T05:36:21Z"}