Hematologic effects of cryogenine and certain selected anti-inflammatory agents
type: CreativeWork
description: Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue. There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.
abstract: Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue. There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.
author: Omaye, Stanley Teruo
keywords: Anti-inflammatory agents, Medicine and Health Sciences
license: http://rightsstatements.org/vocab/NKC/1.0/
date published: 1972-01-01T08:00:00Z
date modified: 2026-07-24T05:36:21Z
provider: University of the Pacific
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of the Pacific