Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue.
There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.
","abstract_html":"<p>Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue.</p><p> There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.</p>","abstract_has_math":false,"creators":["Omaye, Stanley Teruo"],"institution":null,"degree_name":"Master of Science (M.S.)","degree_level":"Thesis","degree_discipline":"Graduate Studies","degree_department":null,"school":null,"contributors":["Marvin H. Malone"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1972,"date_issued":"1972-01-01T08:00:00Z","date_published":"1972-01-01T08:00:00Z","updated_at":"2026-07-24T05:36:21Z","subjects":["Anti-inflammatory agents","Medicine and Health Sciences"],"languages":[],"rights":[],"rights_urls":["http://rightsstatements.org/vocab/NKC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://scholarlycommons.pacific.edu/uop_etds/418","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Marvin H. Malone"]},{"key":"dc:creator","label":"Author","values":["Omaye, Stanley Teruo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["1972-01-01T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Graduate Studies"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Anti-inflammatory agents","Medicine and Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["http://rightsstatements.org/vocab/NKC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarlycommons.pacific.edu/uop_etds/418"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue.
There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.
"]},{"key":"dc:source","label":"Dc Source","values":["126"]},{"key":"dc:title","label":"Title","values":["Hematologic effects of cryogenine and certain selected anti-inflammatory agents"]}]}],"canonical_facts":{"dc:contributor":["Marvin H. Malone"],"dc:creator":["Omaye, Stanley Teruo"],"dc:date.available":["1972-01-01T08:00:00Z"],"dc:description.abstract":["Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue.
There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.
"],"dc:identifier":["https://scholarlycommons.pacific.edu/uop_etds/418"],"dc:rights":["http://rightsstatements.org/vocab/NKC/1.0/"],"dc:source":["126"],"dc:subject":["Anti-inflammatory agents","Medicine and Health Sciences"],"dc:title":["Hematologic effects of cryogenine and certain selected anti-inflammatory agents"],"thesis:degree_discipline":["Graduate Studies"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (M.S.)"]},"updated_at":"2026-07-24T05:36:21Z"}