It seems possible that efforts to discover essential chemical differences which might exist between normal and malignant cells will eventually reveal the secret of cancer and thereby lead to new approaches to safer and more selective chemotherapy.
One objective of this study is to find that part of this molecule that causes it to concentrate in the tumor and thence make a smaller size compound which has similar concentration characteristics to tumor as tetracycline. For this purpose, an attempt was made in this study to synthesize the right side ring of Chlorotetracycline, the structure of which is shown below. [see PDF]
","abstract_html":"<p>It seems possible that efforts to discover essential chemical differences which might exist between normal and malignant cells will eventually reveal the secret of cancer and thereby lead to new approaches to safer and more selective chemotherapy.</p><p> One objective of this study is to find that part of this molecule that causes it to concentrate in the tumor and thence make a smaller size compound which has similar concentration characteristics to tumor as tetracycline. For this purpose, an attempt was made in this study to synthesize the right side ring of Chlorotetracycline, the structure of which is shown below. [see PDF]</p>","abstract_has_math":false,"creators":["Tomomatsu, Hideo"],"institution":null,"degree_name":"Master of Science (M.S.)","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Emerson G. Cobb","W. H. Wadman"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1960,"date_issued":"1960-01-01T08:00:00Z","date_published":"1960-01-01T08:00:00Z","updated_at":"2026-07-24T05:36:21Z","subjects":["University of the Pacific Dissertations","Chemistry","Physical Sciences and Mathematics"],"languages":[],"rights":[],"rights_urls":["http://rightsstatements.org/vocab/NKC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://scholarlycommons.pacific.edu/uop_etds/367","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Emerson G. Cobb","W. H. Wadman"]},{"key":"dc:creator","label":"Author","values":["Tomomatsu, Hideo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-29T08:41:31Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["University of the Pacific Dissertations","Chemistry","Physical Sciences and Mathematics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["http://rightsstatements.org/vocab/NKC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarlycommons.pacific.edu/uop_etds/367"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["It seems possible that efforts to discover essential chemical differences which might exist between normal and malignant cells will eventually reveal the secret of cancer and thereby lead to new approaches to safer and more selective chemotherapy.
One objective of this study is to find that part of this molecule that causes it to concentrate in the tumor and thence make a smaller size compound which has similar concentration characteristics to tumor as tetracycline. For this purpose, an attempt was made in this study to synthesize the right side ring of Chlorotetracycline, the structure of which is shown below. [see PDF]
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One objective of this study is to find that part of this molecule that causes it to concentrate in the tumor and thence make a smaller size compound which has similar concentration characteristics to tumor as tetracycline. For this purpose, an attempt was made in this study to synthesize the right side ring of Chlorotetracycline, the structure of which is shown below. [see PDF]
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