{"id":{"repo_id":"u-pacific","oai_identifier":"oai:scholarlycommons.pacific.edu:uop_etds-1363"},"canonical_url":"https://search.dev.ndltd.org/etd/u-pacific/oai:scholarlycommons.pacific.edu:uop_etds-1363","repository":{"repo_id":"u-pacific","name":"University of the Pacific","base_url":"https://scholarlycommons.pacific.edu/do/oai/"},"display":{"title":"Tetracycline-7-boronic acid","abstract":"The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue.","abstract_html":"The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue.","abstract_has_math":false,"creators":["Rhoads, William Denham"],"institution":null,"degree_name":"Master of Science (M.S.)","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Emerson G. Cobb"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1960,"date_issued":"1960-01-01T08:00:00Z","date_published":"1960-01-01T08:00:00Z","updated_at":"2026-07-24T05:36:21Z","subjects":["Boron compounds","Chemistry","Physical Sciences and Mathematics"],"languages":[],"rights":[],"rights_urls":["http://rightsstatements.org/vocab/NKC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://scholarlycommons.pacific.edu/uop_etds/364","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Emerson G. Cobb"]},{"key":"dc:creator","label":"Author","values":["Rhoads, William Denham"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-29T08:41:38Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Boron compounds","Chemistry","Physical Sciences and Mathematics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["http://rightsstatements.org/vocab/NKC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarlycommons.pacific.edu/uop_etds/364"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue."]},{"key":"dc:source","label":"Dc Source","values":["22"]},{"key":"dc:title","label":"Title","values":["Tetracycline-7-boronic acid"]}]}],"canonical_facts":{"dc:contributor":["Emerson G. Cobb"],"dc:creator":["Rhoads, William Denham"],"dc:date.available":["2018-06-29T08:41:38Z"],"dc:description.abstract":["The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue."],"dc:identifier":["https://scholarlycommons.pacific.edu/uop_etds/364"],"dc:rights":["http://rightsstatements.org/vocab/NKC/1.0/"],"dc:source":["22"],"dc:subject":["Boron compounds","Chemistry","Physical Sciences and Mathematics"],"dc:title":["Tetracycline-7-boronic acid"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (M.S.)"]},"updated_at":"2026-07-24T05:36:21Z"}