University of the Pacific
Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
Abstract
dc:description.abstract<p>Spray drying is widely used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites were subjected to Fourier Transform Infrared Sprectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (XRPD). The data showed that the crystalline model drugs were converted to amorphous form upon spray drying, whereas the physical mixtures did not change their crystallinity. The effect of the amorphous forms produced by Spray drying on apparent solubility and intrinsic dissolution rate was determined. All the spray dried composites exhibited higher apparent solubility and intrinsic dissolution rate when compared to the pure drugs and their physical mixtures. The stability of the spray dried composites upon storage was also determined. The amorphous nature of the compounds in the spray dried composites were retained during 3 months storage as shown by FTIR, DSC and XRPD characterization and their apparent solubility and intrinsic dissolution rates also did not change.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science (M.S.)
- Level thesis:degree_level
- Thesis - Pacific Access Restricted
- Discipline thesis:degree_discipline
- Pharmaceutical and Chemical Sciences
- Year dc:date.available
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Nannapaneni, Vijaysri
- Contributors dc:contributor
-
- Bhaskara Jasti
Subjects
dc:subject × 10Rights
dc:rightsIdentifiers
dc:identifier.*- Identifier
- 9781124523606
- OAI identifier oai:identifier
- oai:scholarlycommons.pacific.edu:uop_etds-1273