Development and characterization of a novel drug dissolution test method using a quartz crystal microbalance

<p>Current dissolution apparatuses require several hundred milligrams of sample per trial, measure dissolution rate indirectly via concentration sampling, and cannot maintain sink conditions throughout the duration of a test. This work describes a novel dissolution testing methodology developed using a commercial quartz crystal microbalance (QCM) system to measure dissolution rates of drugs while overcoming the limitations of current dissolution methods. The apparatus was characterized for a sample drug system of benzoic acid dissolved using a dissolution medium of deionized water at flow rates of 1000, 100, 50, and 10 &mgr;L/min. Using an analysis method that combines the responses of resonance frequency and resistance of the quartz crystal during dissolution, the dissolution rate of benzoic acid was found to be 4.029 ± 0.743, 2.026 ± 0.913, 1.565 ± 0.349, and 1.060 ± 0.103 % mass/s, for each flow rate, respectively. The QCM dissolution apparatus method can be used to measure drug dissolution directly by quantifying mass loss (rather than indirectly via concentration changes as with current methods), reduce sample sizes compared with current methods by three orders of magnitude onto the microgram scale, and maintain sink conditions throughout the duration of the test.</p>

Name thesis:degree_name

Master of Science (M.S.)

Level thesis:degree_level

Thesis - Pacific Access Restricted

Discipline thesis:degree_discipline

Engineering

Year dc:date.available

2015

Author dc:creator

• Bonoan, Janpierre A.

Contributors dc:contributor

• Shelly Gulati

• Biomedical engineering
• Pharmacy sciences
• Applied sciences
• Health and environmental sciences
• Drug dissolution
• Quartz crystal microbalance
• Engineering

Licence

• http://rightsstatements.org/vocab/InC/1.0/

Identifier

9781321698374

OAI identifier oai:identifier

oai:scholarlycommons.pacific.edu:uop_etds-1216