Effect of Delta-Tocotrienol and Grape Seed Polyphenol on Lipid Profile in C57BL/6J Mice with a Western-Like Diet-Included Non-Alcoholic Steatohepatitis

Non-alcoholic steatohepatitis (NASH), the second phase in liver disease, occurs when adults consume high calorie, high fat diets. Fat accumulated in the liver causes inflammation and irreversible hardening. Grape seed polyphenol (GSP) and d-tocotrienol (d-T3) may have benefits in reducing NASH. We observed the effects of dietary GSP & d-T3 (separated and combined: GSP - 2%; d-T3 - 0.05%) in C57BL/6J mice fed a high calorie high fat diet for 20 weeks. Hepatic cholesterol, triglycerides, and vitamin E; serum cholesterol, triglycerides, vitamin E, and free fatty acids were assayed. Hepatic total cholesterol was lowest in GSP diet and GSP(2%)+dT3(0.05%) diet groups. Hepatic triglycerides were lowest in the GSP(2%)+dT3(0.05%) diet group. Hepatic vitamin E levels were lowest in the GSP(2%)+dT3(0.05%) diet group. Serum cholesterol was lowest in GSP diet and GSP(2%)+dT3(0.05%) diet groups. Serum vitamin E was lowest in the GSP diet group. Serum triglycerides and FFA's were similar among the groups.

Name thesis:degree_name

Master

Level thesis:degree_level

Master of Science

Discipline thesis:degree_discipline

Nutrition

Grantor

Texas Woman's University

Year dc:date.issued

2013

Author dc:creator

• Mendez, Melissa

Chair dc:contributor.committeechair

• Imrhan, Victorine

Committee members dc:contributor.committeemember

• Juma, Shanil
• Vijayagopal, Parakat

• Nutrition

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/11274/757

OAI identifier oai:identifier

oai:twu-ir.tdl.org:11274/757