{"id":{"repo_id":"texas","oai_identifier":"oai:repositories.lib.utexas.edu:2152/ETD-UT-2010-05-663"},"canonical_url":"https://search.dev.ndltd.org/etd/texas/oai:repositories.lib.utexas.edu:2152/ETD-UT-2010-05-663","repository":{"repo_id":"texas","name":"University of Texas","base_url":"https://repositories.lib.utexas.edu/server/oai/request"},"display":{"title":"Development of a bioreactor imaging system for characterizing embryonic stem cell-derived cardiomyocytes","abstract":"Cardiovascular disease (CVD) affects more than 70 million Americans and is the number one cause of mortality in the United States. Because the regenerative capacity of adult tissues such as the heart is limited, human embryonic stem cells (hESC) have emerged as a source for potential cardiac therapies. However, despite the use of a variety of biochemical differentiation protocols, current yields of hESC-derived cardiomyocytes (CM) have been low. In the case of hESC-CM, which are inherently electromechanically active, additional forms of inducing a mature cardiac fate have not been fully explored. In order to non-invasively visualize and quantify biochemical, electrical, and mechanical stimulation on hESC-CM differentiation in future studies, a bioreactor imaging system has been developed and is described in this report.","abstract_html":"Cardiovascular disease (CVD) affects more than 70 million Americans and is the number one cause of mortality in the United States. Because the regenerative capacity of adult tissues such as the heart is limited, human embryonic stem cells (hESC) have emerged as a source for potential cardiac therapies. However, despite the use of a variety of biochemical differentiation protocols, current yields of hESC-derived cardiomyocytes (CM) have been low. In the case of hESC-CM, which are inherently electromechanically active, additional forms of inducing a mature cardiac fate have not been fully explored. In order to non-invasively visualize and quantify biochemical, electrical, and mechanical stimulation on hESC-CM differentiation in future studies, a bioreactor imaging system has been developed and is described in this report.","abstract_has_math":false,"creators":["Abilez, Oscar John"],"institution":"The University of Texas at Austin","degree_name":"Master of Science in Engineering","degree_level":"Masters","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":["Suggs, Laura J."],"committee_chairs":[],"committee_members":["Roy, Krishnendu"],"year":2010,"date_issued":"2010-05","date_published":"2010-05","updated_at":"2026-07-24T05:01:06Z","subjects":["Cardiovascular disease","Heart","Human embryonic stem cell","hESC","Cardiomyocytes","Bioreactor","Imaging system","Regenerative medicine","Tissue engineering"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2152/ETD-UT-2010-05-663","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Suggs, Laura J."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Roy, Krishnendu"]},{"key":"dc:creator","label":"Author","values":["Abilez, Oscar John"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-09-21T14:11:28Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-09-21T14:11:28Z","2010-09-21T14:11:40Z"]},{"key":"dc:date.issued","label":"Date","values":["2010-05"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Engineering"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["The University of Texas at Austin"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cardiovascular disease","Heart","Human embryonic stem cell","hESC","Cardiomyocytes","Bioreactor","Imaging system","Regenerative medicine","Tissue engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2152/ETD-UT-2010-05-663"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["text"]},{"key":"dc:description.abstract","label":"Abstract","values":["Cardiovascular disease (CVD) affects more than 70 million Americans and is the number one cause of mortality in the United States. Because the regenerative capacity of adult tissues such as the heart is limited, human embryonic stem cells (hESC) have emerged as a source for potential cardiac therapies. However, despite the use of a variety of biochemical differentiation protocols, current yields of hESC-derived cardiomyocytes (CM) have been low. In the case of hESC-CM, which are inherently electromechanically active, additional forms of inducing a mature cardiac fate have not been fully explored. In order to non-invasively visualize and quantify biochemical, electrical, and mechanical stimulation on hESC-CM differentiation in future studies, a bioreactor imaging system has been developed and is described in this report."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Development of a bioreactor imaging system for characterizing embryonic stem cell-derived cardiomyocytes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Suggs, Laura J."],"dc:contributor.committeemember":["Roy, Krishnendu"],"dc:creator":["Abilez, Oscar John"],"dc:date.accessioned":["2010-09-21T14:11:28Z"],"dc:date.available":["2010-09-21T14:11:28Z","2010-09-21T14:11:40Z"],"dc:date.issued":["2010-05"],"dc:description":["text"],"dc:description.abstract":["Cardiovascular disease (CVD) affects more than 70 million Americans and is the number one cause of mortality in the United States. Because the regenerative capacity of adult tissues such as the heart is limited, human embryonic stem cells (hESC) have emerged as a source for potential cardiac therapies. However, despite the use of a variety of biochemical differentiation protocols, current yields of hESC-derived cardiomyocytes (CM) have been low. In the case of hESC-CM, which are inherently electromechanically active, additional forms of inducing a mature cardiac fate have not been fully explored. 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