Progress towards a highly efficient and accurate platform for enantiomeric excess determination

Enantiomeric excess (ee) determination remains as the bottleneck for high throughput screening of asymmetric catalysts. The work described herein sought to expand on two previously developed ee sensing assays from our lab– an iron based amine assembly and a zinc based multicomponent assembly. To start, the substituent effect of the zinc multicomponent dynamic assembly for secondary chiral alcohol ee determination was investigated. A new assembly with a higher dynamic range and smaller error was observed. Additionally, potential cooperative binding to the multicomponent assembly was investigated. Furthermore, this work included some preliminary results for a concurrent sensing platform for molecules with chiral amine and alcohol moieties.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Chemistry

Grantor

The University of Texas at Austin

Year dc:date.issued

2016

Author dc:creator

• Lin, Chung-Yon

Advisor dc:contributor.advisor

• Anslyn, Eric V., 1960-

Committee members dc:contributor.committeemember

• Sessler, Jonathan L
• Keatinge-Clay, Adrian
• Jones, Richard A

• Supramolecular chemistry
• Chiroptical

Language dc:language.iso

en

Identifier

doi:10.15781/T2W66986P

OAI identifier oai:identifier

oai:repositories.lib.utexas.edu:2152/39663