Developing test strips for naked-eye detection of alpha-hydroxy acids using indicator-displacement assays: an application of molecular recognition

An Indicator-Displacement Assay (IDA) was used to study the kinetics of reactions that produce tartrate. Two examples are the dihydroxylation of maleic acid and fumaric acid catalyzed by osmium tetroxide in water, and the hydrolysis of D-dimethyl tartrate. The assay employed a receptor that has 1,3,5-trisubstituted-2,4,6- triethylbenzene scaffold incorporating boronic acid and guanidinium moieties as functional sensing components. The same assay was found to be useful in developing test strips for “naked-eye detection” of tartrate and other α-hydroxyacids, by treating filter papers and various polymer matrices with the receptor and indicator. Also, investigations into the effect of pH on the host-indicator affinity, and the development of a new synthetic host to sense aspartic acid and glutamic acid are presented. In other words, chapters 1 and 2 are summary of background and review of previous and current works in molecular recognition. New works are found in chapters 3, 4, and 5.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Chemistry

Grantor

The University of Texas at Austin

Year dc:date.issued

2005

Author dc:creator

• Nguyen, Binh Thanh

Advisor dc:contributor.advisor

• Anslyn, Eric V.

Statement dc:rights

• Copyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.

Language dc:language.iso

eng

Identifier

b60805225

OAI identifier oai:identifier

oai:repositories.lib.utexas.edu:2152/2025