{"id":{"repo_id":"tenn-hsc","oai_identifier":"oai:dc.uthsc.edu:dissertations-1538"},"canonical_url":"https://search.dev.ndltd.org/etd/tenn-hsc/oai:dc.uthsc.edu:dissertations-1538","repository":{"repo_id":"tenn-hsc","name":"University of Tennessee Health Science Center","base_url":"https://dc.uthsc.edu/do/oai/"},"display":{"title":"Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis","abstract":"<p>Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.</p>","abstract_html":"&lt;p&gt;Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.&lt;/p&gt;","abstract_has_math":false,"creators":["Zhao, Guannan"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Biomedical Sciences","degree_department":null,"school":null,"contributors":["Junming Yue, PhD"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-11-01T07:00:00Z","date_published":"2020-11-01T07:00:00Z","updated_at":"2026-07-24T05:00:45Z","subjects":["Deoxyhypusine synthase","EIF5A","Epithelial to mesenchymal transition","Hypusination","Ovarian cancer","TGFβ","Diseases","Medical Cell Biology","Medical Sciences","Medicine and Health Sciences","Neoplasms"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://dc.uthsc.edu/dissertations/536","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Junming Yue, PhD"]},{"key":"dc:creator","label":"Author","values":["Zhao, Guannan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2021-11-24T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Deoxyhypusine synthase","EIF5A","Epithelial to mesenchymal transition","Hypusination","Ovarian cancer","TGFβ","Diseases","Medical Cell Biology","Medical Sciences","Medicine and Health Sciences","Neoplasms"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://dc.uthsc.edu/dissertations/536"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["<p>Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.</p>"]},{"key":"dc:title","label":"Title","values":["Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis"]}]}],"canonical_facts":{"dc:contributor":["Junming Yue, PhD"],"dc:creator":["Zhao, Guannan"],"dc:date.available":["2021-11-24T08:00:00Z"],"dc:description.abstract":["<p>Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.</p>"],"dc:identifier":["https://dc.uthsc.edu/dissertations/536"],"dc:subject":["Deoxyhypusine synthase","EIF5A","Epithelial to mesenchymal transition","Hypusination","Ovarian cancer","TGFβ","Diseases","Medical Cell Biology","Medical Sciences","Medicine and Health Sciences","Neoplasms"],"dc:title":["Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis"],"thesis:degree_discipline":["Biomedical Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T05:00:45Z"}