University of Tennessee Health Science Center
Reprogramming to Pluripotency Using Small Molecule Compounds
Abstract
dc:description.abstract<p>The generation of induced pluripotent stem cells (iPSCs) through the use of small molecule compounds has evolved as a potential cellular reprogramming strategy. Individually, specific small molecule compounds have previously been shown to replace reprogramming transcription factors or enhance the efficiency of cellular reprogramming. More recently, a combination of small molecule compounds can replace all of the reprogramming factors. In this review, we describe in detail the generation of chemically induced pluripotent stem cells using small molecule inhibitors and activators that target either downstream protein kinases or modify chromatin structure to promote somatic cell reprogramming. In addition, epigenetic modulating small molecule compounds that enhance cellular reprogramming and functionally replace some reprogramming factors are discussed.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science (MS)
- Level thesis:degree_level
- Thesis
- Discipline thesis:degree_discipline
- Biomedical Sciences
- Year dc:date.available
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Greenberg, Brittany E.
- Contributors dc:contributor
-
- R. Kiplin Guy, PhD
Subjects
dc:subject × 8Identifiers
dc:identifier.*- Repository record dc:identifier
- https://dc.uthsc.edu/dissertations/97
- OAI identifier oai:identifier
- oai:dc.uthsc.edu:dissertations-1103