DESIGN OF A SCREENING PROCESS FOR THE DEVELOPMENT

We have initiated the development of a screening platform to design a library of small molecules on the same solid support surface. This solid support surface, and the chemistry involved, can be utilized as a means of developing lead target molecules, namely ligands and catalysts. Evidence shows the successful assembly of both simple amino acids, as well as successful employment of our synthetic compounds. We support our efforts by showing compatibility for binding studies with larger macromolecules. Thus, intrigue remains by the prospects of this project. Challenges within our efforts are highlighted and emphasis is placed on presenting solutions to current issues, in order to attain further development. Notwithstanding difficulty, the desire to establish efficient processes for the discovery of lead target molecules and to ascertain the utility of our synthesized compounds, can be captured within this body of work. Lastly, the framework for continued efforts has been set to enable future progression.

Grantor dc:publisher

Temple University. Libraries

Year dc:date.issued

2011

Author dc:creator

• Jackson, Marcus J.

Advisor dc:contributor.advisor

• Schafmeister, Christian

Committee member dc:contributor.committeemember

• Schafmeister, Christian

• Chemistry
• Design
• Chemistry, Organic
• Solid-phase Peptide Synthesis
• Spot Synthesis

Statement dc:rights

• IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

eng

Dc Identifier Other

864885671

OAI identifier oai:identifier

oai:scholarshare.temple.edu:20.500.12613/1512