{"id":{"repo_id":"tdl","oai_identifier":"oai:tdl-ir.tdl.org:20.500.12503/29413"},"canonical_url":"https://search.dev.ndltd.org/etd/tdl/oai:tdl-ir.tdl.org:20.500.12503/29413","repository":{"repo_id":"tdl","name":"Texas Digital Library","base_url":"https://tdl-ir.tdl.org/server/oai/request"},"display":{"title":"Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation","abstract":"Wray, David Walter, Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. This study was designed to test the hypothesis that an age-related vagal dysfunction compromises arterial blood pressure (ABP) regulation. Changes in heart rate (HR) and ABP during lower body negative pressure (LBNP) were compared between ten elderly (≥60 yrs) and ten young (≤30 yrs) adults. A separate, young group (n=10) was also assessed following muscarinic cholinergic (MC) blockade with atropine (central and peripheral receptor blockade) or glycopyrrolate (peripheral receptor blockade) to simulate vagal dysfunction. During the onset of LBNP -40 too, orthostatic hypotension (OH) was observed in both the older subjects and the post-blockade younger subjects, with a diminished HR response. Furthermore, the reflex response to hypertensive stimuli was augmented in the post-blockade younger subjects, also associated with a diminution in HR response. We concluded that age-related or pharmacologically stimulated vagal dysfunction compromises ABP regulation during hypotensive and hypertensive stimuli, and that the difference between atropine and glycopyrrolate was insignificant.","abstract_html":"Wray, David Walter, Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. This study was designed to test the hypothesis that an age-related vagal dysfunction compromises arterial blood pressure (ABP) regulation. Changes in heart rate (HR) and ABP during lower body negative pressure (LBNP) were compared between ten elderly (≥60 yrs) and ten young (≤30 yrs) adults. A separate, young group (n=10) was also assessed following muscarinic cholinergic (MC) blockade with atropine (central and peripheral receptor blockade) or glycopyrrolate (peripheral receptor blockade) to simulate vagal dysfunction. During the onset of LBNP -40 too, orthostatic hypotension (OH) was observed in both the older subjects and the post-blockade younger subjects, with a diminished HR response. Furthermore, the reflex response to hypertensive stimuli was augmented in the post-blockade younger subjects, also associated with a diminution in HR response. We concluded that age-related or pharmacologically stimulated vagal dysfunction compromises ABP regulation during hypotensive and hypertensive stimuli, and that the difference between atropine and glycopyrrolate was insignificant.","abstract_has_math":false,"creators":["Wray, David Walter"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Shi, Xiangrong","Gwirtz, Patricia A.","Raven, Peter B."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1999,"date_issued":"1999-12-01","date_published":"1999-12-01","updated_at":"2026-07-27T21:19:11Z","subjects":["Biology","Cardiovascular System","Circulatory and Respiratory Physiology","Life Sciences","Medical Sciences","Medicine and Health Sciences","Physiology","Peripheral muscarinic cholinergic receptors","arterial blood pressure regulation","central muscarinic cholinergic receptors","ABP","heart rate","lower body negative pressure","MC","atropine","glycopyrrolate","vagal dysfunction","reflex response"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.12503/29413","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Shi, Xiangrong","Gwirtz, Patricia A.","Raven, Peter B."]},{"key":"dc:creator","label":"Author","values":["Wray, David Walter"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2019-08-22T21:32:52Z","2026-03-24T17:16:51Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2019-08-22T21:32:52Z"]},{"key":"dc:date.issued","label":"Date","values":["1999-12-01"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology","Cardiovascular System","Circulatory and Respiratory Physiology","Life Sciences","Medical Sciences","Medicine and Health Sciences","Physiology","Peripheral muscarinic cholinergic receptors","arterial blood pressure regulation","central muscarinic cholinergic receptors","ABP","heart rate","lower body negative pressure","MC","atropine","glycopyrrolate","vagal dysfunction","reflex response"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/20.500.12503/29413"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.12503/29413"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Wray, David Walter, Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. This study was designed to test the hypothesis that an age-related vagal dysfunction compromises arterial blood pressure (ABP) regulation. Changes in heart rate (HR) and ABP during lower body negative pressure (LBNP) were compared between ten elderly (≥60 yrs) and ten young (≤30 yrs) adults. A separate, young group (n=10) was also assessed following muscarinic cholinergic (MC) blockade with atropine (central and peripheral receptor blockade) or glycopyrrolate (peripheral receptor blockade) to simulate vagal dysfunction. During the onset of LBNP -40 too, orthostatic hypotension (OH) was observed in both the older subjects and the post-blockade younger subjects, with a diminished HR response. Furthermore, the reflex response to hypertensive stimuli was augmented in the post-blockade younger subjects, also associated with a diminution in HR response. We concluded that age-related or pharmacologically stimulated vagal dysfunction compromises ABP regulation during hypotensive and hypertensive stimuli, and that the difference between atropine and glycopyrrolate was insignificant."]},{"key":"dc:title","label":"Title","values":["Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation"]}]}],"canonical_facts":{"dc:contributor":["Shi, Xiangrong","Gwirtz, Patricia A.","Raven, Peter B."],"dc:creator":["Wray, David Walter"],"dc:date.accessioned":["2019-08-22T21:32:52Z","2026-03-24T17:16:51Z"],"dc:date.available":["2019-08-22T21:32:52Z"],"dc:date.issued":["1999-12-01"],"dc:description.abstract":["Wray, David Walter, Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. 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We concluded that age-related or pharmacologically stimulated vagal dysfunction compromises ABP regulation during hypotensive and hypertensive stimuli, and that the difference between atropine and glycopyrrolate was insignificant."],"dc:identifier":["https://hdl.handle.net/20.500.12503/29413"],"dc:identifier.uri":["https://hdl.handle.net/20.500.12503/29413"],"dc:language":["en"],"dc:subject":["Biology","Cardiovascular System","Circulatory and Respiratory Physiology","Life Sciences","Medical Sciences","Medicine and Health Sciences","Physiology","Peripheral muscarinic cholinergic receptors","arterial blood pressure regulation","central muscarinic cholinergic receptors","ABP","heart rate","lower body negative pressure","MC","atropine","glycopyrrolate","vagal dysfunction","reflex response"],"dc:title":["Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T21:19:11Z"}