{"id":{"repo_id":"tdl","oai_identifier":"oai:tdl-ir.tdl.org:1969.1/3335"},"canonical_url":"https://search.dev.ndltd.org/etd/tdl/oai:tdl-ir.tdl.org:1969.1/3335","repository":{"repo_id":"tdl","name":"Texas Digital Library","base_url":"https://tdl-ir.tdl.org/server/oai/request"},"display":{"title":"Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence","abstract":"In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual wavelength system has been developed in order to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this paper a dual wavelength, closed-loop, system was designed and a model was developed to extract the glucose concentration information. The system and model were tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, non-moving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0-600mg/dl) for either laser wavelength (523nm or 635nm). In the presence of moving birefringence, each individual wavelength produced standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample. This research also shows promising preliminary results that the error is less than 25mg/dl in presence of a motion induced cornea birefringence artifact in NZW rabbits?? eyes.","abstract_html":"In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual wavelength system has been developed in order to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this paper a dual wavelength, closed-loop, system was designed and a model was developed to extract the glucose concentration information. The system and model were tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, non-moving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0-600mg/dl) for either laser wavelength (523nm or 635nm). In the presence of moving birefringence, each individual wavelength produced standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample. This research also shows promising preliminary results that the error is less than 25mg/dl in presence of a motion induced cornea birefringence artifact in NZW rabbits?? eyes.","abstract_has_math":false,"creators":["Wan, Qiujie"],"institution":"Texas A&M University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Cot??, Gerard"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006-04-12","date_published":"2006-04-12","updated_at":"2026-08-21T22:21:56Z","subjects":["diabetes","noninvasive","polarimetry","glucose sensing","birefringence"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1969.1/3335","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://tdl-ir.tdl.org/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Atdl-ir.tdl.org%3A1969.1%2F3335","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cot??, Gerard"]},{"key":"dc:creator","label":"Author","values":["Wan, Qiujie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2006-04-12T16:06:50Z","2017-04-07T19:51:22Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2006-04-12T16:06:50Z","2017-04-07T19:51:22Z"]},{"key":"dc:date.issued","label":"Date","values":["2006-04-12"]},{"key":"dc:publisher","label":"Institution","values":["Texas A&M University"]},{"key":"dc:type","label":"Dc Type","values":["Book","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["diabetes","noninvasive","polarimetry","glucose sensing","birefringence"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1969.1/3335"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual wavelength system has been developed in order to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this paper a dual wavelength, closed-loop, system was designed and a model was developed to extract the glucose concentration information. The system and model were tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, non-moving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0-600mg/dl) for either laser wavelength (523nm or 635nm). In the presence of moving birefringence, each individual wavelength produced standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample. This research also shows promising preliminary results that the error is less than 25mg/dl in presence of a motion induced cornea birefringence artifact in NZW rabbits?? eyes."]},{"key":"dc:title","label":"Title","values":["Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence"]}]}],"canonical_facts":{"dc:contributor":["Cot??, Gerard"],"dc:creator":["Wan, Qiujie"],"dc:date.accessioned":["2006-04-12T16:06:50Z","2017-04-07T19:51:22Z"],"dc:date.available":["2006-04-12T16:06:50Z","2017-04-07T19:51:22Z"],"dc:date.issued":["2006-04-12"],"dc:description.abstract":["In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual wavelength system has been developed in order to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this paper a dual wavelength, closed-loop, system was designed and a model was developed to extract the glucose concentration information. The system and model were tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, non-moving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0-600mg/dl) for either laser wavelength (523nm or 635nm). In the presence of moving birefringence, each individual wavelength produced standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample. This research also shows promising preliminary results that the error is less than 25mg/dl in presence of a motion induced cornea birefringence artifact in NZW rabbits?? eyes."],"dc:identifier.uri":["http://hdl.handle.net/1969.1/3335"],"dc:language.iso":["en_US"],"dc:publisher":["Texas A&M University"],"dc:subject":["diabetes","noninvasive","polarimetry","glucose sensing","birefringence"],"dc:title":["Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence"],"dc:type":["Book","Thesis"]},"updated_at":"2026-08-21T22:21:56Z"}