Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice)
type: CreativeWork
description: In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified.
abstract: In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified.
author: Rajasalu, Tarvo
date published: 2007-10-04T07:11:39Z
date modified: 2026-07-24T06:23:48Z
provider: University of Tartu
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Tartu