{"id":{"repo_id":"tartu","oai_identifier":"oai:dspace.ut.ee:10062/3991"},"canonical_url":"https://search.dev.ndltd.org/etd/tartu/oai:dspace.ut.ee:10062/3991","repository":{"repo_id":"tartu","name":"University of Tartu","base_url":"http://dspace.ut.ee/oai/request"},"display":{"title":"Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice)","abstract":"In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified.","abstract_html":"In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified.","abstract_has_math":false,"creators":["Rajasalu, Tarvo"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007-10-04T07:11:39Z","date_published":"2007-10-04T07:11:39Z","updated_at":"2026-07-24T06:23:48Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10062/3991"],"render_values":[{"text":"hdl:10062/3991","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2007-10-04T07:11:39Z"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10062/3991"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified."]},{"key":"dc:title","label":"Title","values":["Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice)"]}]}],"canonical_facts":{"dc:date.issued":["2007-10-04T07:11:39Z"],"dc:description.other":["In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified."],"dc:identifier":["hdl:10062/3991"],"dc:title":["Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice)"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T06:23:48Z"}