{"id":{"repo_id":"tamu","oai_identifier":"oai:oaktrust.library.tamu.edu:1969.1/1595508"},"canonical_url":"https://search.dev.ndltd.org/etd/tamu/oai:oaktrust.library.tamu.edu:1969.1/1595508","repository":{"repo_id":"tamu","name":"Texas A&M University","base_url":"https://oaktrust.library.tamu.edu/server/oai/request"},"display":{"title":"The Regulatory Mechanism of Dietary Pattern in TMJ Condyle Growth","abstract":"Background: The mechanism of chondrocyte transdifferentiation into bone cells during postnatal condylar growth is unknown. Purpose: To quantify the effects of dietary loading on condylar chondrocyte transdifferentiation. Research Design: Chondrocyte tracing was performed in 21 Aggrecan-Cre;R26Tomato;2.3Col1a1-GFP mice. After tamoxifen injection at 3 weeks, they were randomly divided into three 6-week diet groups: hard, soft, or combination (4 weeks soft, 2 weeks hard) (n=7). Radiographic analysis, cell proliferation, immunostaining, and cell lineage tracing were performed. Results: Soft diet mice exhibited significantly shorter mandibular length, reduced chondrogenic activity, and fewer chondrocyte-derived bone cells in the condylar head and mid-condylar process than hard diet group. The combination mice, however, showed significant improvements, with outcomes similar to the hard diet mice. Conclusions: Dietary loading affects condylar growth by regulating chondrocyte transdifferentiation.","abstract_html":"Background: The mechanism of chondrocyte transdifferentiation into bone cells during postnatal condylar growth is unknown. Purpose: To quantify the effects of dietary loading on condylar chondrocyte transdifferentiation. Research Design: Chondrocyte tracing was performed in 21 Aggrecan-Cre;R26Tomato;2.3Col1a1-GFP mice. After tamoxifen injection at 3 weeks, they were randomly divided into three 6-week diet groups: hard, soft, or combination (4 weeks soft, 2 weeks hard) (n=7). Radiographic analysis, cell proliferation, immunostaining, and cell lineage tracing were performed. Results: Soft diet mice exhibited significantly shorter mandibular length, reduced chondrogenic activity, and fewer chondrocyte-derived bone cells in the condylar head and mid-condylar process than hard diet group. The combination mice, however, showed significant improvements, with outcomes similar to the hard diet mice. Conclusions: Dietary loading affects condylar growth by regulating chondrocyte transdifferentiation.","abstract_has_math":false,"creators":["Doan, Kelly 1995-"],"institution":"Texas A&M University","degree_name":"Master of Science","degree_level":"Masters","degree_discipline":"Oral Biology","degree_department":null,"school":null,"contributors":[],"advisors":["Jing, Yan"],"committee_chairs":[],"committee_members":["Ruest, Louisbruno","Kesterke, Matthew"],"year":2025,"date_issued":"2025-05","date_published":"2025-05","updated_at":"2026-08-21T16:48:44Z","subjects":["Health Sciences, Dentistry"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1969.1/1595508","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://oaktrust.library.tamu.edu/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Aoaktrust.library.tamu.edu%3A1969.1%2F1595508","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Jing, Yan"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Ruest, Louisbruno","Kesterke, Matthew"]},{"key":"dc:creator","label":"Author","values":["Doan, Kelly 1995-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-09-12T21:57:49Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-05"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Oral Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Texas A&M University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Dentistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["English"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1969.1/1595508"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: The mechanism of chondrocyte transdifferentiation into bone cells during postnatal condylar growth is unknown. Purpose: To quantify the effects of dietary loading on condylar chondrocyte transdifferentiation. Research Design: Chondrocyte tracing was performed in 21 Aggrecan-Cre;R26Tomato;2.3Col1a1-GFP mice. After tamoxifen injection at 3 weeks, they were randomly divided into three 6-week diet groups: hard, soft, or combination (4 weeks soft, 2 weeks hard) (n=7). Radiographic analysis, cell proliferation, immunostaining, and cell lineage tracing were performed. Results: Soft diet mice exhibited significantly shorter mandibular length, reduced chondrogenic activity, and fewer chondrocyte-derived bone cells in the condylar head and mid-condylar process than hard diet group. The combination mice, however, showed significant improvements, with outcomes similar to the hard diet mice. Conclusions: Dietary loading affects condylar growth by regulating chondrocyte transdifferentiation."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The Regulatory Mechanism of Dietary Pattern in TMJ Condyle Growth"]}]}],"canonical_facts":{"dc:contributor.advisor":["Jing, Yan"],"dc:contributor.committeemember":["Ruest, Louisbruno","Kesterke, Matthew"],"dc:creator":["Doan, Kelly 1995-"],"dc:date.accessioned":["2025-09-12T21:57:49Z"],"dc:date.issued":["2025-05"],"dc:description.abstract":["Background: The mechanism of chondrocyte transdifferentiation into bone cells during postnatal condylar growth is unknown. Purpose: To quantify the effects of dietary loading on condylar chondrocyte transdifferentiation. Research Design: Chondrocyte tracing was performed in 21 Aggrecan-Cre;R26Tomato;2.3Col1a1-GFP mice. After tamoxifen injection at 3 weeks, they were randomly divided into three 6-week diet groups: hard, soft, or combination (4 weeks soft, 2 weeks hard) (n=7). Radiographic analysis, cell proliferation, immunostaining, and cell lineage tracing were performed. Results: Soft diet mice exhibited significantly shorter mandibular length, reduced chondrogenic activity, and fewer chondrocyte-derived bone cells in the condylar head and mid-condylar process than hard diet group. The combination mice, however, showed significant improvements, with outcomes similar to the hard diet mice. Conclusions: Dietary loading affects condylar growth by regulating chondrocyte transdifferentiation."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/1969.1/1595508"],"dc:language.iso":["English"],"dc:subject":["Health Sciences, Dentistry"],"dc:title":["The Regulatory Mechanism of Dietary Pattern in TMJ Condyle Growth"],"dc:type":["Thesis"],"thesis:degree_discipline":["Oral Biology"],"thesis:degree_level":["Masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Texas A&M University"]},"updated_at":"2026-08-21T16:48:44Z"}